Issues

Summary: Spiral patterns in plants follow precise mathematical rules. This Hypothesis shows how these patterns are progressively canalized during development by the physical interactions between the young organs at the tip of plant stems.

Summary: This Review discusses the lens-containing eyes of a variety of Metazoa with a focus on ontogeny and highlights what evolutionary developmental biology continues to teach us about fundamental principles of biological systems.

Summary: This Review aims to shed new light on the development of laterality in the stomach and intestine, challenging classical models of left-right asymmetric gut morphogenesis.

Summary: This Review examines transcriptional nuclear microenvironments in the context of embryogenesis, covering their formation, physical properties, functions in gene regulation and how they could facilitate the evolution of regulatory elements.

Summary: Salivary glands rely on recruitment of differentiated cell populations as well as stem cells to ensure rapid regeneration and recovery of secretory cells.

Summary: The genesis of myogenic stem cells and their homing process during development are poorly known processes. We identified SIX homeoproteins as important regulators of this homing.

Summary: Mouse Tek mutants and zebrafish tek morphants display severe defects but zebrafish tek mutants do not; we show that tek morpholinos cause off-target effects and that tek is missing in most fish.

Summary: A novel and JNK-independent role of the membrane protein Raw is revealed in regulating the secretory pathway and thereby promoting dendrite pruning in Drosophila.

Summary: The O-fucosyltransferase SPY regulates root hair patterning independently of DELLA proteins and gibberellin signaling when modulating epidermal tissue patterning in Arabidopsis thaliana roots.

Highlighted Article: Localisation of YAP, a key factor during the first cell fate decision, is linked to individual blastomere geometry within the three-dimentional environment of the preimplantation embryo.

Summary: The homeobox gene gsx2 mediates rostro-caudal positional signaling to specify the identity of neurons in the zebrafish inferior olivary nuclei from neural progenitors expressing the proneural gene ptf1a.

Summary: This study reveals a role for the Golgi-associated RAB GTPases RAB6A/A′ in the lactogenic function of the mammary gland.

Highlighted Article: Four SUPPRESSOR OF PHYA-105 (SPA) genes destabilize the thermosensor phyB and are crucial for stabilizing PIF4 through direct phosphorylation, fine-tuning thermomorphogenesis in response to high ambient temperature.

Summary: Bcl6 is required for pre-TCR-induced differentiation from CD4⁻CD8⁻ double-negative to CD4⁺CD8⁺ double-positive cells in the thymus, and attenuates Notch1 signalling after β-selection.

Highlighted Article: Experimental deregulation of erythropoietin signaling results in an aberrant migration and a permanent neuronal mispositioning, leading to abnormal formation of neuronal networks and sensory behavioral deficits later in life.

Summary: Planar cell polarity proteins regulate planar polarization. We show that secreted Wnts regulate a subset of planar cell polarity proteins, which coordinate with Vangl2 to govern sensory cell polarization.

Highlighted Article: Iroquois transcription factors link morphogenesis to pattern formation by regulating chromatid segregation and promoting daughter cell intercalations that shape the early limb bud.