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Summary: This short Spotlight summarizes the current state of pre-clinical and clinical research using pluripotent stem cells for regenerative therapy, and the influence of developmental biology-inspired approaches.


Summary: The development of the corpus callosum occurs during a protracted period of embryonic and postnatal life. It shows remarkable exuberance and plasticity. Its failure leads to a diversity of CC malformations.


Highlighted Article: Novel mechanisms of the Grl-Smyd2 network govern vertebrate CM renewal and heart regeneration, which might be relevant in developing strategies for regeneration interventions in humans.

Highlighted Article: The coordinated action of the WNT, BMP and Notch pathways controls both cell fate determination and patterning in the embryonic stomach.


Summary: This study reports a role for the COP-II secretory pathway and the cargo Col2a1 in controlling the migration of lymphatic endothelial cells in the developing embryo.


Summary:cyp19a1a-mediated suppression of dmrt1 establishes a bipotential gonad and female fate acquisition, possibly through rbpms2, which is required for female fates, even in the absence of Dmrt1.

Highlighted Article: Pou2f1 upregulates Pou2f2 expression, which in turn represses the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina.

Highlighted Article: We show that lag-1 positively autoregulates during LIN-12-mediated cell fate decisions during cell fate specification via consensus LAG-1/CSL binding sites within a conserved high occupancy target sequence.

Summary: Zebrafish Nedd8 plays an important role in controlling ovarian maturation through suppressing androgen receptor activity.

Highlighted Article: The prion protein family member doppel interacts with endothelial receptor tyrosine kinases to activate intracellular signaling pathways and promote blood vessel morphogenesis in the developing central nervous system.

Summary: Morpholino knockdown experiments in the annelid Capitella teleta demonstrate that the dorsal-ventral axis is primarily patterned by the Activin/Nodal pathway of the TGF-β superfamily, rather than by the BMP pathway.

Summary: The arthropod-specific juvenile hormone promotes fat body cell polyploidization and insect vitellogenesis via a previously unidentified signaling cascade including LCMT1, PP2A, FoxO and Cdc2/Orc5.


Highlighted Article: The FaceBase Consortium provides dynamic, freely available resources, including comprehensive datasets on human craniofacial development and animal models, and develops innovative tools for data visualization and analysis.

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