Cover: Interactive 3D model of an E18.5 typically developing mouse skull based on microCT data. Different colours indicate distinct bones. See Research article by Samuels et al. (dev191213).
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New trends in cellular therapy
Summary: This short Spotlight summarizes the current state of pre-clinical and clinical research using pluripotent stem cells for regenerative therapy, and the influence of developmental biology-inspired approaches.
Development and plasticity of the corpus callosum
Summary: The development of the corpus callosum occurs during a protracted period of embryonic and postnatal life. It shows remarkable exuberance and plasticity. Its failure leads to a diversity of CC malformations.
STEM CELLS AND REGENERATION
The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase
Highlighted Article: Novel mechanisms of the Grl-Smyd2 network govern vertebrate CM renewal and heart regeneration, which might be relevant in developing strategies for regeneration interventions in humans.
Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors
Highlighted Article: The coordinated action of the WNT, BMP and Notch pathways controls both cell fate determination and patterning in the embryonic stomach.
Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo
Summary: This study reports a role for the COP-II secretory pathway and the cargo Col2a1 in controlling the migration of lymphatic endothelial cells in the developing embryo.
Loss of dmrt1 restores zebrafish female fates in the absence of cyp19a1a but not rbpms2a/b
Summary: cyp19a1a-mediated suppression of dmrt1 establishes a bipotential gonad and female fate acquisition, possibly through rbpms2, which is required for female fates, even in the absence of Dmrt1.
Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina
Highlighted Article: Pou2f1 upregulates Pou2f2 expression, which in turn represses the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina.
Positive autoregulation of lag-1 in response to LIN-12 activation in cell fate decisions during C. elegans reproductive system development
Highlighted Article: We show that lag-1 positively autoregulates during LIN-12-mediated cell fate decisions during cell fate specification via consensus LAG-1/CSL binding sites within a conserved high occupancy target sequence.
Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity
Summary: Zebrafish Nedd8 plays an important role in controlling ovarian maturation through suppressing androgen receptor activity.
The vascular endothelial cell-expressed prion protein doppel promotes angiogenesis and blood-brain barrier development
Highlighted Article: The prion protein family member doppel interacts with endothelial receptor tyrosine kinases to activate intracellular signaling pathways and promote blood vessel morphogenesis in the developing central nervous system.
Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta
Summary: Morpholino knockdown experiments in the annelid Capitella teleta demonstrate that the dorsal-ventral axis is primarily patterned by the Activin/Nodal pathway of the TGF-β superfamily, rather than by the BMP pathway.
Juvenile hormone acts through FoxO to promote Cdc2 and Orc5 transcription for polyploidy-dependent vitellogenesis
Summary: The arthropod-specific juvenile hormone promotes fat body cell polyploidization and insect vitellogenesis via a previously unidentified signaling cascade including LCMT1, PP2A, FoxO and Cdc2/Orc5.
TECHNIQUES AND RESOURCES
FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research
Highlighted Article: The FaceBase Consortium provides dynamic, freely available resources, including comprehensive datasets on human craniofacial development and animal models, and develops innovative tools for data visualization and analysis.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Development a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Development presents… Outstanding Paper Prize Finalists
On Wednesday 19 April, Development hosted a webinar celebrating the finalists for Development’s Inaugural Outstanding Paper Prize. The talks and Q&As were hosted by our Deputy Editor, Steve Wilson (UCL).
Development Journal Meeting 2023
The Abstract deadline for our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ is 23 June 2023. Find out more and apply to Developments 2023 Journal Meeting here.
Keeping up with the Node
Thirteen years on from its launch, the Node continues to be a place to share research stories, opinions, job adverts and event listings. Development have published a recent Editorial showcasing some of our most popular features, as well as introducing some new initiatives.