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Summary: This Review discusses recent discoveries of molecular, cellular and mechanosensitive mechanisms of valve development in mammals and zebrafish, along with relevance to human congenital and acquired valve disease.

Summary: This Review discusses recent insights into the mechanisms driving asymmetric cell division, and its contribution to binary cell fate decisions, using established and emergent model organisms.


Summary: Generation of new hypothalamic neurons after birth is a multistep process involving cell division and cell movements that are controlled by Fgf10.

Summary: The canonical BMP transcription factors SMAD1/5 promote the self-amplification of cortical radial glial cells, controlling neurogenesis and growth during corticogenesis in amniotes.

Summary: Expression and phenotypic analyses reveal that connexin 43 gap junctional intercellular communication (Cx43-GJIC) regulates cell fate decisions in the lateral skeletal precursor cells. Inhibition of Cx43-GJIC favors expression of evx1 and joint formation.


Highlighted Article: Contrary to expectations, auxin transport in epidermis is neither required nor sufficient for vein patterning; instead, auxin transport in inner tissues is both required and sufficient for vein patterning.


Highlighted Article: Cell-labelling and lineage-tracing experiments showed that, although zebrafish larvae lack resident neuronal precursors, enteric neurogenesis occurs from trunk neural crest-derived precursors during development and injury, and is promoted by prucalopride.

Summary: Hypermethylated in cancer 1 (Hic1) in testicular smooth muscle cells mediates the postnatal testicular development and secretion of fibronectin to modulate the testicular microenvironment.

Summary: The RALF1-FERONIA interaction modulates plant growth and development, and this might also involve endocytosis of certain PM proteins by the clathrin-mediated endocytosis pathway.

Highlighted Article: Plant embryos can form from extra-embryonic suspensor cells. Examination of embryogenesis induced by various triggers, and analysis of fate markers, revealed that this process resembles somatic embryogenesis.

Summary: Maternally loaded mRNAs localize non-homogenously within Caenorhabditis elegans early embryos, correlating with their translational status and lineage-specific fates

Highlighted Article: Simultaneous mutagenesis of two transcription factors or their cell type-specific enhancers causes divergent fate specification. Fate decisions involve the complex interplay of multiple factors within a temporally narrow window.

Summary: Hypoxanthine interacts with oocyte-derived paracrine factors to fine-tune granulosa cell proliferation in growing ovarian follicles.


Summary: We describe a new pan-otic CRE driver, Slc26a9P2ACre, with little activity in the brain or middle ear, and demonstrate its utility by manipulating FGF signaling and assessing hearing loss.

Summary: Trophoblast-specific Cre/loxP recombination is achieved by using the natural permeability barrier of the blastocyst, restricting Tat-Cre activity to the trophectoderm.

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