Issues
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Cover image
Cover Image
Cover: Caenorhabditis elegans embryos imaged using single-molecule FISH to detect maternally-loaded mRNAs (clu-1, chs-1, imb-2, erm-1, F40G12.11, lem-3, nos-2 and cpg-2) in combination with cellular markers (PH::GFP, GLH-1::GFP, and DAPI). mRNAs accumulate at cell membranes, nuclear peripheries and within P granules. See Research article by Parker et al. (dev186817).
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RESEARCH HIGHLIGHTS
EDITORIAL
INTERVIEWS
REVIEWS
Mechanisms of heart valve development and disease
Summary: This Review discusses recent discoveries of molecular, cellular and mechanosensitive mechanisms of valve development in mammals and zebrafish, along with relevance to human congenital and acquired valve disease.
Principles and mechanisms of asymmetric cell division
Summary: This Review discusses recent insights into the mechanisms driving asymmetric cell division, and its contribution to binary cell fate decisions, using established and emergent model organisms.
STEM CELLS AND REGENERATION
Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus
Summary: Generation of new hypothalamic neurons after birth is a multistep process involving cell division and cell movements that are controlled by Fgf10.
A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex
Summary: The canonical BMP transcription factors SMAD1/5 promote the self-amplification of cortical radial glial cells, controlling neurogenesis and growth during corticogenesis in amniotes.
Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins
Summary: Expression and phenotypic analyses reveal that connexin 43 gap junctional intercellular communication (Cx43-GJIC) regulates cell fate decisions in the lateral skeletal precursor cells. Inhibition of Cx43-GJIC favors expression of evx1 and joint formation.
RESEARCH REPORT
Vein patterning by tissue-specific auxin transport
Highlighted Article: Contrary to expectations, auxin transport in epidermis is neither required nor sufficient for vein patterning; instead, auxin transport in inner tissues is both required and sufficient for vein patterning.
RESEARCH ARTICLES
De novo enteric neurogenesis in post-embryonic zebrafish from Schwann cell precursors rather than resident cell types
Highlighted Article: Cell-labelling and lineage-tracing experiments showed that, although zebrafish larvae lack resident neuronal precursors, enteric neurogenesis occurs from trunk neural crest-derived precursors during development and injury, and is promoted by prucalopride.
Development and function of smooth muscle cells is modulated by Hic1 in mouse testis
Summary: Hypermethylated in cancer 1 (Hic1) in testicular smooth muscle cells mediates the postnatal testicular development and secretion of fibronectin to modulate the testicular microenvironment.
The RALF1-FERONIA interaction modulates endocytosis to mediate control of root growth in Arabidopsis
Summary: The RALF1-FERONIA interaction modulates plant growth and development, and this might also involve endocytosis of certain PM proteins by the clathrin-mediated endocytosis pathway.
Suspensor-derived somatic embryogenesis in Arabidopsis
Highlighted Article: Plant embryos can form from extra-embryonic suspensor cells. Examination of embryogenesis induced by various triggers, and analysis of fate markers, revealed that this process resembles somatic embryogenesis.
mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage
Summary: Maternally loaded mRNAs localize non-homogenously within Caenorhabditis elegans early embryos, correlating with their translational status and lineage-specific fates
Simultaneous deletion of Prdm1 and Vsx2 enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes
Highlighted Article: Simultaneous mutagenesis of two transcription factors or their cell type-specific enhancers causes divergent fate specification. Fate decisions involve the complex interplay of multiple factors within a temporally narrow window.
Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells
Summary: Hypoxanthine interacts with oocyte-derived paracrine factors to fine-tune granulosa cell proliferation in growing ovarian follicles.
TECHNIQUES AND RESOURCES
Slc26a9P2ACre: a new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia
Summary: We describe a new pan-otic CRE driver, Slc26a9P2ACre, with little activity in the brain or middle ear, and demonstrate its utility by manipulating FGF signaling and assessing hearing loss.
Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination
Summary: Trophoblast-specific Cre/loxP recombination is achieved by using the natural permeability barrier of the blastocyst, restricting Tat-Cre activity to the trophectoderm.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
