Cover: Micrographs of C. elegans anchor cells (cdh-3>mCherry::moeABD, magenta) atop the uterine-vulval basement membrane (laminin::GFP, green), expressing endogenously-tagged transcription factors (nuclear, green), grouped by column (left to right: egl-43::GFP, fos-1::GFP, hlh-2::GFP and nhr-67::GFP). Each row represents a different RNAi perturbation [top to bottom: empty vector, egl-43(RNAi), fos-1(RNAi), hlh-2(RNAi) and nhr-67(RNAi)]. See Research article by Medwig-Kinney et al. (dev185850)
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Unravelling spiral cleavage
Summary: Spiral cleavage is one of the most under-investigated, yet widespread developmental strategies in animals: a powerful system for exploring fundamental questions in evolutionary developmental biology.
X chromosome inactivation in human development
Summary: This Review discusses our current knowledge of how X chromosome inactivation, an important model for epigenetic gene regulation, is initiated and controlled during early human embryo development.
Parallels between wound healing, epimorphic regeneration and solid tumors
Summary: Although regeneration and cancer retain certain core differences as research models, emerging studies could allow us to bridge the biological mechanisms found in both and tackle important questions using a unified approach.
STEM CELLS AND REGENERATION
Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain
Summary: A combination of lineage tracing and single cell sequencing identifies specific markers and functional subpopulations of adult newborn neurons in the zebrafish forebrain.
Dual role of Jam3b in early hematopoietic and vascular development
Summary: A cell adhesion molecule, Jam3b, regulates both hematopoietic and vascular development via two independent signaling pathways in the zebrafish embryo.
Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation
Summary: Analysis and quantification of chromatin accessibility and 5-hydroxymethylcytosine reveals cis-regulatory dynamics and associated transcription factors involved in intestinal stem cell differentiation.
Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression
Highlighted Article: Cilia movement and its induced asymmetric Hh signalling are the two key regulators for the establishment of amphioxus left-right asymmetry, likely representing an evolutionarily conserved mechanism in deuterostomes.
Dosage-dependent requirements of Magoh for cortical interneuron generation and survival
Highlighted Article: Genetics, live imaging and genomics demonstrate that the RNA-binding protein Magoh, which controls progenitor mitosis, interneuron generation and survival, is required in a dosage-dependent manner for interneuron development.
Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia
Highlighted Article: Neural crest cells migrate through dense extracellular matrix and mesoderm towards specific embryonic targets. We have discovered that AQP-1, a water channel, affects cell speed, filopodia stability and ECM degradation.
Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans
Highlighted Article: Investigations of cytokinesis reveal reproducible patterns during early embryonic development and specialized cytokinesis during epithelial polarization at morphogenesis in Caenorhabditis elegans.
The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis
Summary: Discovery of novel PAX-SIX-EYA-DACH and GATA network interactions in Drosophila hematopoiesis reveal that human SIX proteins can associate with GATA1, stimulate GATA1-dependent transcription and enhance human erythropoiesis in vitro.
A developmental gene regulatory network for C. elegans anchor cell invasion
Summary: Transcription factors that independently regulate specification of the C. elegans anchor cell function together in a gene regulatory network encompassing cell cycle-dependent and -independent sub-circuits that coordinate basement membrane invasion.
Development Journal Meeting 2023
We are delighted to announce that our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ will be held from 17-20 September 2023 at Wotton House, Surrey, UK. Find out more and register here.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.
preLights 5th Birthday webinar
preLights, our preprint highlighting service, is celebrating its 5th birthday this year. To mark the occasion, join us online on 14 March 2023 at 16:00 GMT for a discussion, led by four preLights alumni, on how to identify and navigate the challenges and opportunities while shaping your career as an early-career researcher.
Transitions in development: Daniel Grimes
Daniel Grimes’s lab studies the consequences of ciliary mutations, including left-right patterning defects and scoliosis. We interviewed Daniel to find out more about his career path, his experience of becoming a group leader and the influence of Jurassic Park.
Preprints in Development
As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.