Issues
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Cover image
Cover Image
Cover: Knocking out a single gene in Lymnaea stagnalis reverses snail coiling. Image shows the wild-type dextral snail (right) and a CRISPR-created sinistral snail (left), which is the 5th generation from an Lsdia1 knockout embryo, 8-F5 (ins1/ins1), in an otherwise totally dextral genetic background. Image courtesy of Dr Hiromi Takahashi of the Kuroda laboratory. See research article by Abe and Kuroda (dev175976).
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RESEARCH HIGHLIGHTS
OBITUARY
Sydney Brenner: a master of science and of wit
Summary: Peter Lawrence reflects on the life and work of Sydney Brenner – ‘the Oscar Wilde of science’.
INTERVIEWS
MEETING REVIEW
Repair, regenerate and reconstruct: meeting the state-of-the-art
Summary: Research reported at the seventh EMBO meeting on the Molecular and Cellular Basis of Regeneration and Tissue Repair included important discoveries on regeneration and provided perspectives for regenerative medicine.
PRIMER
The cytoneme connection: direct long-distance signal transfer during development
Summary: During development, specialized cells produce signals that are distributed among receiving cells to induce a variety of cellular behaviors and organize tissues. This Primer discusses how the dynamic regulation of cytonemes facilitates such signal transfer.
REVIEW
The origins and non-canonical functions of macrophages in development and regeneration
Summary: This Review discusses current knowledge of the developmental origins of various macrophage populations and the non-canonical functions of macrophages in development, regeneration and tissue repair.
STEM CELLS AND REGENERATION
Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo
Summary: Zebrafish microglia help to prevent the spread of tissue damage in the aftermath of a brain injury by migrating to the lesion site and clearing it of dead cells.
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis
Summary: The ciliary GTPase Arl3 is required to maintain mitotic spindle orientation and planar cell polarity signaling during skin development, processes that are crucial to the maintenance of epithelial architecture.
The Shh receptor Boc is important for myelin formation and repair
Summary: The Sonic hedgehog receptor Boc is implicated in oligodendrogenesis and axon calibre regulation during development, and participates in microglia and/or macrophage transition from highly to faintly ramified morphology during myelin repair.
RESEARCH REPORT
The development of CRISPR for a mollusc establishes the formin Lsdia1 as the long-sought gene for snail dextral/sinistral coiling
Highlighted Article: CRISPR/Cas9 reveals that Lsdia1 is the gene that determines the body handedness of Lymnaea stagnalis from the undifferentiated one-cell stage, through the decisive 3rd cleavage and via the nodal and Pitx pathways.
RESEARCH ARTICLES
A dual function of FGF signaling in Xenopus left-right axis formation
Summary: FGF signaling induces and patterns the frog left-right organizer in the early gastrula and regulates the morphogenesis of the flow sensor following specification of the precursor tissue.
Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process
Highlighted Article: CRISPR-generated mutants and theoretical modeling show that Dll is a crucial activator of butterfly wing eyespot center differentiation.
Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule
Summary: In the Malpighian tubules, GATAe is necessary not only for the morphology and function of the tubule but for the integrative physiology of the animal as a whole.
Myocardial differentiation is dependent upon endocardial signaling during early cardiogenesis in vitro
Highlighted Article: Interaction between endocardial cells and cardiomyocytes during the initial stages of in vitro cardiac differentiation promotes myocardial differentiation and maturation through the BMP signaling pathway.
The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish
Highlighted Article: Investigation of the Crumbs polarity protein Crb2a in zebrafish reveals a novel role in cardiac development via regulation of cell-cell adhesion and apicobasal polarity.
Yap and its subcellular localization have distinct compartment-specific roles in the developing lung
Highlighted Article: Hippo-Yap has several roles during lung development. We define these roles and show how they change with developmental age and the location of a cell along the proximal-distal axis of the lung.
A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death
Summary: Cut regulates the programmed death of neural stem cells by altering cohesin levels and promoting a more open chromatin conformation to allow cell death gene expression.
Paxillin-dependent regulation of apical-basal polarity in mammary gland morphogenesis
Summary: During mammary gland morphogenesis, paxillin regulates HDAC6 activity and microtubule acetylation to control cell polarization, cell shape and ductal branching.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
