Summary: This Review discusses the identification, regulation and heterogeneity of neural stem cells and examines recent insights into their transcriptomic properties and mechanism of persistence into adulthood.
STEM CELLS AND REGENERATION
Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites
Summary: Analyses of conditional and genetic null mice reveal that HeyL and Hey1 function redundantly in MuSCs, and that HeyL requires Hes1 for effective DNA binding and biological activity.
Summary: Ecrg4-deficient mice reveal that loss of Ecrg4 not only maintains proliferation of neural stem cells in vitro and in vivo, but also enhances spatial recognition and memory.
Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea
Summary: Several supporting cell subtypes, in particular pillar cells and Deiters’ cells, act as the source of spontaneously regenerated hair cells in the neonatal mouse cochlea.
Non-apoptotic function of Drosophila caspase activation in epithelial thorax closure and wound healing
Summary: Drosophila caspase 9 (Dronc), which is spatio-temporally activated in a non-apoptotic context, delays epithelial closure and may be involved in ROS generation.
Summary: Cellular, transcriptome and gene functional analyses revealed that tail regeneration of amphioxus is a vertebrate-like epimorphic process, in which the BMP signaling pathway plays key roles.
Summary: Sequence variation in the JAZ degron may influence conformational changes of the OsJAZ1 protein that are needed for efficient signaling, and so confer specificity and sensitivity in JA signaling during rice development.
TOP1α regulates FLOWERING LOCUS C expression by coupling histone modification and transcription machinery
Summary: TOP1α interacts with SDG8 and recruits RNA polymerase II to promote early transcriptional elongation by maintaining the open chromatin state and adding histone markers associated with active transcription.
Highlighted Article: Sesamoid bones originate from pools of Sox9+/Scx+ chondroprogenitors, and a combination of genetic and mechanical regulatory programs is applied to achieve anatomical and ultimately functional variation during sesamoid bone development.
ATML1 activity is restricted to the outermost cells of the embryo through post-transcriptional repressions
Summary: The activity of ATML1, which promotes shoot epidermal cell fate in Arabidopsis thaliana, is post-transcriptionally repressed in the inner cells of the embryos.
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta
Highlighted Article: Global loss of the USP22 deubiquitinase, an integral subunit of the SAGA chromatin remodeler, reveals an unexpected role in the regulation of signaling cascades in endothelial and perivascular cells of the developing mouse placenta.
Highlighted Article: Studies using Nkx2-5, Tbx1 and Fgfr1/Fgfr2 mutant mice reveal how a genetic predisposition to developing a heart defect can combine with short-term gestational hypoxia to cause defects and foetal death.
Summary: Sensory neurons and glia, which breach the epithelial barrier between an organism and its environment, exhibit epithelial properties themselves and develop through mechanisms shared with other epithelia.
The HMG box transcription factors Sox1a and Sox1b specify a new class of glycinergic interneuron in the spinal cord of zebrafish embryos
Summary: A novel spinal neuronal V2 subtype, V2s, is described in zebrafish embryos and proposed to be required for fast escape responses.
Nell2 regulates the contralateral-versus-ipsilateral visual projection as a domain-specific positional cue
Summary: Nell2 is expressed in the domain of the visual thalamus, where ipsilateral retinal axons terminate, and contributes to establishment of the eye-specific visual projection by specifically inhibiting contralateral retinal axons.
Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes
Summary: Regulation of both mRNA transcription and stability plays a crucial role in postnatal liver development; in particular, Cnot complex-mediated mRNA decay is essential for postnatal liver functional maturation.
Genetic interactions support an inhibitory relationship between bone morphogenetic protein 2 and netrin 1 during semicircular canal formation
Summary: Bmp2-conditional mutant analyses support the hypothesis that presumptive crista induces canal genesis zone in the canal pouch to express Bmp2, which promotes canal formation by restricting Ntn1 expression to the resorption domain.