Issues

Summary: Maria Elena Torres-Padilla reflects on her career and discusses the overlap between the epigenetics and developmental biology fields, and the importance of inclusivity in science.

Summary: In this Development at a Glance article, we discuss examples of homotypic and heterotypic collective cell migration during development and cancer metastasis.

Summary: This Spotlight discusses strategies that can be used to unlock the endogenous regenerative potential of the mammalian retina, highlighting potential technical pitfalls and important considerations.

Summary: Recent work has characterized barriers to cell fate change. This Review explores the possibility that these barriers play a role during alternative cell fate transitions as well as in tumorigenesis.

Summary: Continuous transcriptome analysis of hemangiogenesis from embryonic stem cells reveals intermediate gastrulation stages that are gradually specified by overlapping transcription factor modules and default smooth muscle fate of FLK1 mesoderm.

Highlighted Article: A FACS-based method for sorting different cell types and their ChIP-seq have provided an in vivo dataset that reveals dynamic histone modifications during neuronal differentiation in Drosophila.

Summary: Sensitized genetic backgrounds of Arabidopsis thaliana reveal a role of JMJ14 in root growth, and ubiquitous JMJ14 gene expression depends on its transcript region, whereas specificity of the JMJ14 protein resides in its FYR domain..

Summary: Drosophila integrin mutants exhibit follicle cell multi-layering because mutant pre-follicle cells detach from the basement membrane and become internalised, not because of a loss of polarity or later defects.

Highlighted Article: Although cardiac-specific long intergenic noncoding RNAs display striking expression patterns in the embryo, they appear largely dispensable for proper heart development.

Summary: A mechanical model of the vertebrate neuroepithelium, based on experimental observations, suggests that the rate of neuronal differentiation influences tissue growth and the shape of lineage-related clones.

Summary: YAP signaling regulates the conversion of simple columnar epithelium into stratified squamous cells in the developing mouse and human esophagus.

Summary: Polarized cellular constriction responding to mechanical stress controls the diameter of a developing epithelial tube during murine epididymal development.

Summary: Conditional deletion of the E2 SUMO-conjugating enzyme in mouse oocytes causes female infertility as a result of compound defects in ovarian follicle development and oocyte meiotic maturation and progression.

Summary: Fenestrae play a principal role in regulation of homeostasis. The fenestral protein Plvap regulates the rate of plasma protein entry from the general circulation into the brain parenchyma.

Summary: Cyclin B2 regulates separase activity through inhibition of phosphorylation, especially in the absence of securin and cyclin B1, during the first meiotic division of mouse oocytes.

Summary: 2D and 3D cultures of mouse primary mammary fibroblasts show that FGF signaling regulates fibroblast proliferation, migration, extracellular matrix production and remodeling, and, importantly, fibroblast-mediated mammary epithelial branching morphogenesis.

Summary: Micro-computed tomography in Drosophila is used to visualize all organs in an intact animal at micron resolution, providing a useful tool for whole-animal phenotyping.