Summary: This Review summarizes the spatial and temporal gene regulatory patterning systems that produce the diversity and organization of neurons in the vertebrate spinal cord.
STEM CELLS AND REGENERATION
C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells
Summary: To switch asymmetric to proliferative cell division, the C. elegans RNT-1/BRO-1 transcriptional repressor opposes POP-1 TCF expression in seam stem cells, which turns POP-1-induced differentiation into self-renewal.
Highlighted Article: During seed and embryo development the E2FA and E2FB transcription factors coordinate cell proliferation with differentiation and accumulation of seed reserves; however, they are not essential for sustaining cell proliferation.
Highlighted Article: The pattern and rate of smooth muscle differentiation is essential to shape the airway epithelium into domain branches in the embryonic mouse lung.
Dorsal convergence of gastrula cells requires Vangl2 and an adhesion protein-dependent change in protrusive activity
Summary: A change in membrane protrusion formation is required for planar cell polarity and directed migration during zebrafish gastrulation.
Synthesis and maintenance of lipid droplets are essential for mouse preimplantation embryonic development
Summary: A method for delipidation of mouse MII oocytes reveals that lipid droplets are newly synthesized even after delipidation, and that their proper storage is important for preimplantation embryonic development.
Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity
Summary: The Scribble/Dlg module, well known for promoting basolateral identity during apical-basal polarity maintenance, has a surprising role in apical-basal polarity initiation, placing it near the top of the network that positions adherens junctions.
Highlighted Article: Gene expression and fate mapping/lineage tracing in zebrafish reveals that the pineal organ develops from the non-neural pre-placodal ectoderm under the control of FGF signalling.
Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis in C. elegans embryos
Summary: Centrosomal Aurora A ensures a single PAR-2 polarity axis in C. elegans embryos.
Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development in C. elegans
Summary: Insulin signaling is involved in C. elegans nervous system development as part of a mechanism that integrates intrinsic and activity-dependent gene expression programs.
Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation
Summary: The Drosophila C2H2 zinc-finger protein Doublefault controls meiotic chromosome segregation and cytokinesis, and is required for cyclin B translation in mature spermatocytes.
Highlighted Article: A Spint2-deficient mouse model of congenital tufting enteropathy (CTE) reveals that overactivation of the membrane-anchored serine protease matriptase in the absence of its inhibitor HAI-2 triggers intestinal failure.
The minimal gap-junction network among melanophores and xanthophores required for stripe pattern formation in zebrafish
Summary: Analysis in zebrafish reveals that Cx39.4 expression in melanophores but not in xanthophores is required for stripe patterning; however, Cx41.8 expression in xanthophores is sufficient for stripe patterning.
Highlighted Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart.