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Summary: Bénédicte Sanson, winner of the BSDB's Cheryll Tickle medal, looks back on her career and discusses the importance of collaboration and interdisciplinarity in science.

Summary: Kate Storey, winner of the BSDB's Waddington Medal, discusses how she came to study neural development, the importance of having a broad skill set in science, and the questions that will dominate the field in the next decade.


Summary: A broad review encompassing basic science to clinical relevance of human placental development.

Summary: This Review summarizes the spatial and temporal gene regulatory patterning systems that produce the diversity and organization of neurons in the vertebrate spinal cord.


Summary: To switch asymmetric to proliferative cell division, the C. elegans RNT-1/BRO-1 transcriptional repressor opposes POP-1 TCF expression in seam stem cells, which turns POP-1-induced differentiation into self-renewal.


Highlighted Article: During seed and embryo development the E2FA and E2FB transcription factors coordinate cell proliferation with differentiation and accumulation of seed reserves; however, they are not essential for sustaining cell proliferation.

Highlighted Article: The pattern and rate of smooth muscle differentiation is essential to shape the airway epithelium into domain branches in the embryonic mouse lung.

Summary: A change in membrane protrusion formation is required for planar cell polarity and directed migration during zebrafish gastrulation.

Summary: A method for delipidation of mouse MII oocytes reveals that lipid droplets are newly synthesized even after delipidation, and that their proper storage is important for preimplantation embryonic development.

Summary: The Scribble/Dlg module, well known for promoting basolateral identity during apical-basal polarity maintenance, has a surprising role in apical-basal polarity initiation, placing it near the top of the network that positions adherens junctions.

Highlighted Article: Gene expression and fate mapping/lineage tracing in zebrafish reveals that the pineal organ develops from the non-neural pre-placodal ectoderm under the control of FGF signalling.

Summary: Centrosomal Aurora A ensures a single PAR-2 polarity axis in C. elegans embryos.

Summary: Insulin signaling is involved in C. elegans nervous system development as part of a mechanism that integrates intrinsic and activity-dependent gene expression programs.

Summary: The Drosophila C2H2 zinc-finger protein Doublefault controls meiotic chromosome segregation and cytokinesis, and is required for cyclin B translation in mature spermatocytes.

Highlighted Article: A Spint2-deficient mouse model of congenital tufting enteropathy (CTE) reveals that overactivation of the membrane-anchored serine protease matriptase in the absence of its inhibitor HAI-2 triggers intestinal failure.

Summary: Analysis in zebrafish reveals that Cx39.4 expression in melanophores but not in xanthophores is required for stripe patterning; however, Cx41.8 expression in xanthophores is sufficient for stripe patterning.

Highlighted Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart.


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