Issues

Summary: This Development at a Glance article describes the core Hippo pathway, its regulation and the roles it plays in animal development.

Summary: This Meeting Review discusses how recent technological advances have impacted the study of cell types and how this might change our view of cell type identity and evolution.

Summary: This Primer summarizes tools and experimental approaches that have made the zebrafish a valuable model for studying organ regeneration.

Summary: This Review describes the regulation and evolution of segment patterning in arthropods, covering the experimental discoveries and conceptual advances of the past 15 years.

Summary: Conditional knockout of p75^NTR in mouse neuronal progenitors results in variable effects on the brain, including a marked decrease in brain volume and impaired thalamic midline closure.

Summary: The left-right asymmetric polarization of the C. elegans Q neuroblasts is mediated through a ligand-independent mechanism that localizes the netrin receptor UNC-40/DCC at the anterior or posterior side of the cell.

Summary: The Drosophila polarity proteins Scribble and Discs Large are key components of the tricellular junction protein complex along with Gliotactin and Bark Beetle.

Summary: A strong genetic interaction between Tbx1 and Pax9 that leads to 4th PAA-derived defects in double heterozygous mice is cell-autonomous within the pharyngeal endoderm.

Summary: An integrated genomic approach identifies Shh-responsive genes and associated regulatory sequences with known and previously uncharacterized roles in cochlear morphogenesis, including genes that prime the cochlea for sensory development.

Summary: A pathway with a complex transcriptional network, including multiple conserved factors, is necessary for final maturation of Drosophila ovarian follicle cells, which is essential for ovulation.

Summary: Genetic studies reveal that transcriptional autoregulation maintains the expression of tbx6 in the presomitic mesoderm of zebrafish embryos.

Summary: CD40L, a novel physiological regulator of early sensory axon growth at the stage when sensory axons are growing to their targets, activates CD40 forward signalling by target-derived and autocrine mechanisms.

Highlighted Article: A new database generated using data from the systematic analysis of pattern formation, proliferation and growth in wild-type and scrib mutant wing imaginal discs: a neoplastic tumor model.