Issues
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Cover image
Cover Image
Cover: A schematic overview of Caenorhabditis elegans, containing the left lateral row of hypodermal seam cells and the QL neuroblast, with the complex and highly regulated mechanisms of polarization and migration of nematode Q neuroblasts represented by geometrical shapes in the background. Design and artwork, inspired by Aboriginal art, by A. Ebbing. See Research article by Ebbing et al. (dev180059).
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RESEARCH HIGHLIGHT
INTERVIEW
DEVELOPMENT AT A GLANCE
Hippo signalling during development
Summary: This Development at a Glance article describes the core Hippo pathway, its regulation and the roles it plays in animal development.
MEETING REVIEW
Exciting times to study the identity and evolution of cell types
Summary: This Meeting Review discusses how recent technological advances have impacted the study of cell types and how this might change our view of cell type identity and evolution.
PRIMER
Model systems for regeneration: zebrafish
Summary: This Primer summarizes tools and experimental approaches that have made the zebrafish a valuable model for studying organ regeneration.
REVIEW
Arthropod segmentation
Summary: This Review describes the regulation and evolution of segment patterning in arthropods, covering the experimental discoveries and conceptual advances of the past 15 years.
STEM CELLS AND REGENERATION
The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex
Summary: Conditional knockout of p75NTR in mouse neuronal progenitors results in variable effects on the brain, including a marked decrease in brain volume and impaired thalamic midline closure.
RESEARCH ARTICLES
Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts
Summary: The left-right asymmetric polarization of the C. elegans Q neuroblasts is mediated through a ligand-independent mechanism that localizes the netrin receptor UNC-40/DCC at the anterior or posterior side of the cell.
Scribble and Discs Large mediate tricellular junction formation
Summary: The Drosophila polarity proteins Scribble and Discs Large are key components of the tricellular junction protein complex along with Gliotactin and Bark Beetle.
Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis
Summary: A strong genetic interaction between Tbx1 and Pax9 that leads to 4th PAA-derived defects in double heterozygous mice is cell-autonomous within the pharyngeal endoderm.
Genomic architecture of Shh-dependent cochlear morphogenesis
Summary: An integrated genomic approach identifies Shh-responsive genes and associated regulatory sequences with known and previously uncharacterized roles in cochlear morphogenesis, including genes that prime the cochlea for sensory development.
Downregulation of homeodomain protein Cut is essential for Drosophila follicle maturation and ovulation
Summary: A pathway with a complex transcriptional network, including multiple conserved factors, is necessary for final maturation of Drosophila ovarian follicle cells, which is essential for ovulation.
Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation
Summary: Genetic studies reveal that transcriptional autoregulation maintains the expression of tbx6 in the presomitic mesoderm of zebrafish embryos.
CD40 forward signalling is a physiological regulator of early sensory axon growth
Summary: CD40L, a novel physiological regulator of early sensory axon growth at the stage when sensory axons are growing to their targets, activates CD40 forward signalling by target-derived and autocrine mechanisms.
TECHNIQUES AND RESOURCES
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
Highlighted Article: A new database generated using data from the systematic analysis of pattern formation, proliferation and growth in wild-type and scrib mutant wing imaginal discs: a neoplastic tumor model.
CORRECTION
PREPRINT HIGHLIGHTS
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
