Summary: The development of animal embryos is initially directed by maternal gene products. This Review discusses the mechanisms that underlie the handover of developmental control to the zygotic genome during the maternal-to-zygotic transition.
Summary: This Review discusses the mechanisms of early endoderm morphogenesis across different model organisms, highlighting a surprising number of conserved features, including cells undergoing an epithelial-to-mesenchymal transition, collective cell migration and mesenychymal-to-epithelial transitions.
STEM CELLS AND REGENERATION
Highlighted Article: Drosophila gonad stem cell niche development is directed to the male or female pathway by the sex-determination factor Doublesex via its downstream target bric a brac.
Kirrel2 is differentially required in populations of olfactory sensory neurons for the targeting of axons in the olfactory bulb
Summary: Loss-of-function analyses in mice demonstrate a role for Kirrel2 in the coalescence of OSN axons in the DII region of the olfactory bulb and suggest that Kirrel-independent mechanisms contribute to axonal coalescence in the DI region.
Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish
Summary: Multiple genome-wide approaches reveal that Npas4l functions as a master regulator by directly inducing a group of transcription factor genes that are crucial for hematoendothelial specification.
Summary: Regulation of reproductive stem elongation in barley by APETALA2 suggests a pivotal role for phase change repression of JA-associated responses to promote internode growth.
Sequence environment of BMP-dependent activating elements controls transcriptional responses to Dpp signaling in Drosophila
Highlighted Article: Reciprocal interactions between BMP-response elements and the cis-regulatory environment control Dpp-dependent transcriptional gene activation in developing Drosophila epithelia.
Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat
Highlighted Article: Alcohol exposure in early pregnancy has sex-specific effects on placenta formation and function in the developing rat embryo.
A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane
Highlighted Article: V0-ATPase controls a late apical trafficking step involved in the maintenance of the apical absorptive intestinal membrane and its silencing phenocopies microvillus inclusion disease in C. elegans.
Highlighted Article: The independent behavior of extracellular matrix and cell monolayer of an epithelium under tension during Drosophila leg development highlights the interplay between tissue mechanics and cell-matrix coupling.