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RESEARCH HIGHLIGHTS

EDITORIAL

INTERVIEWS

Summary: Edith Heard, new Director General of the European Molecular Biology Laboratory (EMBL), discusses her X chromosome inactivation research, her plans for EMBL and women in science.

REVIEW

Summary: This Review discusses the mechanisms that regulate neuronal migration and associated disorders, with particular focus on appropriate in vivo and in vitro model systems.

HUMAN DEVELOPMENT

Summary: Live morphological staging reveals common strengths and limitations of differentiating 3D retinal organoid cultures across multiple human pluripotent stem cell lines.

STEM CELLS AND REGENERATION

Highlighted Article: A single bifacial stem cell that is characterized by the combined activity of PXY (TDR), SMXL5 and WOX4 genes generates both wood and bast during radial plant growth.

Highlighted Article: Transcriptional profiling of dividing cells during early limb regeneration reveals an immunomodulatory role for blastemal progenitors through il-8/cxcr-1/2 signaling.

RESEARCH ARTICLES

Highlighted Article: Vertebrates develop nervous systems with numerous cells. Study of cell proliferation in the lamprey nervous system links this to the evolution of a ventricular proliferation zone regulated by Notch signalling.

Summary: All-trans retinoic acid made by Sertoli cells is instrumental to spermatogenesis and is specifically required for spermatid release.

Summary: During anteroposterior axis elongation, neuromesodermal and lateral mesoderm axial progenitors undergo dynamic transcriptomic change, while the adjacent notochord progenitors are stable and coordinate elongation.

Summary: Genetic and biochemical studies revealed an unusual mechanism by which targeted protein degradation regulates and remodels the specialized ring canal cytoskeleton during Drosophila development.

Summary: The transcription factors NTT and STK control enzyme- and transporter-encoding genes involved in cell wall polysaccharide and lipid distribution in gynoecial medial domain cells in Arabidopsis.

Summary: Microtubule motor proteins kinesin and dynein directly carry yolk syncytial nuclei along microtubules towards the vegetal pole, mediated by the LINC complex, which acts as an adaptor between nuclei and motor proteins.

TECHNIQUES AND RESOURCES

Summary: A clonal analysis approach based on CRISPR-mediated excision, which allows control over the frequency of clonal labelling, is proposed and tested in the beetle Tribolium castaneum.

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