Issues
-
Cover image
Cover Image
Cover: Scanning electron microscope image of an Arabidopsis thaliana fruit of the kawak mutant, revealing unfused carpels, internal medial tissues, such as ovules, and an anther-like structure fused to a carpel (left side). The image is false-coloured to indicate different tissue types and internal structures. KAWAK, a direct target of the transcription factors NTT and STK, encodes the ABCG15 transporter, is probably involved in lipid transport and is required for the correct formation of fruits in Arabidopsis. See Research article by Herrera-Ubaldo et al. (dev172395).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
EDITORIAL
INTERVIEWS
An interview with Edith Heard
Summary: Edith Heard, new Director General of the European Molecular Biology Laboratory (EMBL), discusses her X chromosome inactivation research, her plans for EMBL and women in science.
REVIEW
Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
Summary: This Review discusses the mechanisms that regulate neuronal migration and associated disorders, with particular focus on appropriate in vivo and in vitro model systems.
HUMAN DEVELOPMENT
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
Summary: Live morphological staging reveals common strengths and limitations of differentiating 3D retinal organoid cultures across multiple human pluripotent stem cell lines.
STEM CELLS AND REGENERATION
Bifacial cambium stem cells generate xylem and phloem during radial plant growth
Highlighted Article: A single bifacial stem cell that is characterized by the combined activity of PXY (TDR), SMXL5 and WOX4 genes generates both wood and bast during radial plant growth.
Blastemal progenitors modulate immune signaling during early limb regeneration
Highlighted Article: Transcriptional profiling of dividing cells during early limb regeneration reveals an immunomodulatory role for blastemal progenitors through il-8/cxcr-1/2 signaling.
RESEARCH ARTICLES
A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait
Highlighted Article: Vertebrates develop nervous systems with numerous cells. Study of cell proliferation in the lamprey nervous system links this to the evolution of a ventricular proliferation zone regulated by Notch signalling.
Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium
Summary: All-trans retinoic acid made by Sertoli cells is instrumental to spermatogenesis and is specifically required for spermatid release.
Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning
Summary: During anteroposterior axis elongation, neuromesodermal and lateral mesoderm axial progenitors undergo dynamic transcriptomic change, while the adjacent notochord progenitors are stable and coordinate elongation.
Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansion
Summary: Genetic and biochemical studies revealed an unusual mechanism by which targeted protein degradation regulates and remodels the specialized ring canal cytoskeleton during Drosophila development.
New roles of NO TRANSMITTING TRACT and SEEDSTICK during medial domain development in Arabidopsis fruits
Summary: The transcription factors NTT and STK control enzyme- and transporter-encoding genes involved in cell wall polysaccharide and lipid distribution in gynoecial medial domain cells in Arabidopsis.
A cargo model of yolk syncytial nuclear migration during zebrafish epiboly
Summary: Microtubule motor proteins kinesin and dynein directly carry yolk syncytial nuclei along microtubules towards the vegetal pole, mediated by the LINC complex, which acts as an adaptor between nuclei and motor proteins.
TECHNIQUES AND RESOURCES
Clonal analysis by tunable CRISPR-mediated excision
Summary: A clonal analysis approach based on CRISPR-mediated excision, which allows control over the frequency of clonal labelling, is proposed and tested in the beetle Tribolium castaneum.
History of our journals

As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.