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RESEARCH HIGHLIGHTS

OBITUARY

Summary: John White reflects on the life and work of John Sulston, a pioneer in developmental studies of the nematode C. elegans.

DEVELOPMENT AT A GLANCE

Summary: This article highlights the diverse, context-dependent roles that Toll/TLRs play beyond innate immunity in determining cell fate and differentiation, including during competition for light in plants and in neurotrophism and plasticity in the CNS.

REVIEW

Summary: This Review discusses how gene duplication and divergence are interwoven with neuronal complexity in Drosophila and vertebrates, highlighting atonal as a platform for understanding proneural gene structure and regulation.

STEM CELLS AND REGENERATION

Summary: Studies using alveolar organoids and in vivo alveolar regrowth post-pneumonectomy establish many dynamic and cell-type-specific roles for BMP signaling in regulating adult alveolar regeneration.

Summary: Secretion of NGF, upregulated by Hes1, by biliary epithelial cells and adjacent mesenchymal cells guides TUBB3-positive nerve fiber extension and regeneration in the hepatic nervous system.

RESEARCH REPORT

Highlighted Article: Retinoic acid induces locally controlled morphological and transcriptional changes in chordoblasts that lead to segmental notochord sheath mineralization, identifying chordoblasts as key skeletogenic cells during chordacentrum development in zebrafish.

RESEARCH ARTICLES

Summary: Kinesin-dependent uniform plus-end-in microtubule organization is required for efficient c4da neuron microtubule breakdown and dendrite pruning in the Drosophila PNS during early pupal phase.

Summary: ECM heparan sulfate proteoglycans are cell-autonomous regulators of ENS development in mouse and chick, with Col18 expression at the wavefront being permissive and agrin expression post-colonization being inhibitory to ENCDC migration.

Summary: Chemical and genetic disruption of the Wnt-PCP pathway disrupts apical actomyosin contraction and cell rearrangements essential for tissue folding, resulting in neural tube closure defects such as spina bifida.

Highlighted Article: Live imaging demonstrates that neural tube progenitors differentiate when displaced from the apical surface, allowing negative feedback control on cell number.

Summary: The Crb complex, Par complex and the endocytic recycling machinery ensure a polarized distribution of aPKC required for actin-based protrusion formation during remodeling of border cell polarity in the Drosophila ovary.

Highlighted Article: A proliferation-independent requirement for the tumor suppressor NF2 (merlin) in intrahepatic bile duct formation during mouse liver development elucidates a novel self-organizing model of duct morphogenesis.

Summary: Co-expression of Rnf12 with Lhx2 in the retina is both necessary and sufficient for Müller gliogenesis, identifying a novel molecular switching mechanism that regulates retinal neurogenesis and gliogenesis.

Highlighted Article: The Arabidopsis transcription factor SHOOT MERISTEMLESS coordinates multiple aspects of meristem function by regulating the expression of other transcription factors with key roles in pluripotency and pattern formation.

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