Issues
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Cover image
Cover Image
Cover: Longitudinal section of adult sciatic nerve from a P0-CreERT2:Confetti mouse in which myelinating Schwann cells were labelled with Confetti fluorophores. Long-term labelling studies have shown that these cells do not turnover in the adult but, following nerve injury, can efficiently re-enter the cell cycle and convert to the progenitor-like Schwann cells that orchestrate peripheral nerve regeneration. See Research article by Stierli et al. (dev170316).
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RESEARCH HIGHLIGHTS
INTERVIEWS
REVIEW
Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Summary: This Review discusses the roles of transcription factors, histone modifications and chromatin organization during heart development and repair, highlighting common mechanisms and possible strategies for targeted regeneration.
STEM CELLS AND REGENERATION
The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population
Highlighted Article: Lineage analysis and long-term labelling studies show that peripheral nerve regeneration is underpinned by the proliferative plasticity of mature cells rather than the activation of a stem cell population.
RESEARCH REPORT
Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse
Summary: Single and double mutants generated in the zebrafish nodal, lefty1 and cerl2/dand5 genes reveal that the mechanisms of left-right patterning are highly conserved between zebrafish and mouse.
RESEARCH ARTICLES
Development of migrating tendon-bone attachments involves replacement of progenitor populations
Summary: During the development of migrating entheses, one progenitor population establishes a simple embryonic tissue, whereas another population is responsible for its postnatal maturation into a complex structure.
Conserved regulatory state expression controlled by divergent developmental gene regulatory networks in echinoids
Summary: Endomesoderm development in distantly related sea urchins is controlled by gene regulatory networks that consist of conserved sets of transcription factors and signals, while circuit architecture evolved.
Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility
Highlighted Article: The protease inhibitor SWM-1 is secreted from muscle and enters the male gonad to regulate sperm differentiation. SWM-1 is also transferred in seminal fluid, in which it can influence sperm success.
Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis
Summary: The FGFR2 ligands FGF3 and FGF10 are required continuously for inner ear morphogenesis, and FGFR2b signaling targets are identified as novel candidates for involvement in inner ear development and function.
The microRNAs let-7 and miR-278 regulate insect metamorphosis and oogenesis by targeting the juvenile hormone early-response gene Krüppel-homolog 1
Summary: Suppression of microRNA-mediated downregulation of Krüppel-homolog 1 by juvenile hormone prevents the precocious metamorphosis of nymphs and stimulates adult female reproduction in Locusta migratoria.
The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis
Summary: The C. elegans cell polarity protein VANG-1 tempers Wnt-mediated neuronal migration by recycling Frizzled receptors from the neuronal membrane.
The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration
Summary: GLI3 plays an important, non-cell-autonomous role in maintaining the organization of the precerebellar migratory streams and the final positioning of precerebellar neurons.
Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation
Highlighted Article: p53 stabilization and p53-mediated cell death are identified as crucial mechanisms underlying zinc deficiency-induced neural tube defects.
Protein association changes in the Hedgehog signaling complex mediate differential signaling strength
Summary: Depending on the magnitude of Hedgehog (Hh) signaling, Smoothened induces conformational changes in Fused within the Hh signaling complex, responsible for the differential activation of gene responses.
The RhoGEF protein Plekhg5 regulates apical constriction of bottle cells during gastrulation
Highlighted Article: The RhoGEF plekhg5 is identified as a blastopore lip-specific gene that, through the organization of actomyosin activity, induces apical constriction, which is required for bottle cell formation during Xenopus gastrulation.
Spatiotemporal control of axillary meristem formation by interacting transcriptional regulators
Summary: Shoot branching uses interacting transcriptional regulators to fine-tune the spatiotemporal expression of STM and, thus, to precisely regulate axillary meristem initiation.
A simplified mechanism for anisotropic constriction in Drosophila mesoderm
Summary: All experimental observation regarding anisotropy of mesoderm constriction in Drosophila may be explained by a simple model that assumes tissue is elastic and the contractile mesodermal domain is asymmetric.
PREPRINT HIGHLIGHTS
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
