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Summary: After 9 years as Editor-in-Chief, Olivier Pourquié reviews Development's progress in that time, and considers the current challenges in the scientific publishing world and how the journal can maintain its place at the heart of the community through this changing environment.

Summary: New Editor-in-Chief James Briscoe discusses his future plans for Development, announces some changes to the editorial team and calls on the community's support to ensure the journal continues to flourish.


Summary: Robb Krumlauff, winner of the SDB's Edwin G. Conklin Award, discusses his career, his research and his approach to mentoring.


Summary: This Review highlights how metabolism can be compartmentalized with regard to space and time, how this can influence cellular pathways, and the signaling roles of this spatiotemporal regulation of metabolism in various developmental contexts.


Summary: Manipulation of developmental signaling pathways and transcription factor expression allows differentiation of human pluripotent stem cells into nutrient-responsive, intestinal enteroendocrine cells.


Summary: Information on hindlimb amputation of one frog leg is mirrored by changes in the physiological state in the contralateral (uninjured) leg, in a phenomenon which we call bioelectric injury mirroring.

Highlighted Article: The transcription factor TEAD4 promotes mtDNA transcription and oxidative energy metabolism in the trophectoderm lineage to ensure early mammalian development.


Summary: Single-cell genetic fate mapping reveals novel progenitor relationships between endoderm-derived organs and demonstrates that individual hepatoblasts contribute both hepatocytes and cholangiocytes to the mature liver.


Summary: Using an erythroid-specific knockout of Scl has shown that Lyl1 can maintain yolk sac erythropoiesis by activation of common target genes including Gata1.

Summary: This study reveals a role for the variant PCGF3/5-PRC1 complex in repression of Meis2 expression in the mouse distal forelimb bud by adjusting the threshold of retinoic acid-related signals.

Summary: Poly(U) polymerase activity is crucial throughout C. elegans germline development, impacting viability, maintenance of germ cell identity and formation of fertilization-competent gametes capable of supporting embryonic development.

Summary: Lens-removal/replacement work in chicken embryos reveals a functional link between lens-mediated and retinoic acid signalling that controls expansion of the eye.

Summary: The combined signaling intensity of Fzd3 and Fzd6 determines the orientation of hair follicles in developing mouse skin: tilted, randomly oriented or vertically oriented.

Highlighted Article: The Golgi-localized calcium pump SPCA1 promotes mouse neurulation by regulating the cytoskeletal dynamics that promote apical constriction, influencing the subcellular localization of myosin II and the actin-remodeling protein cofilin 1.

Summary: We define the tissue-specific structural, cellular and molecular effects of activating Fgfr2 mutations in bone, cartilage and epithelium that combine to cause midfacial dysgenesis in mouse models of craniosynostosis.

Highlighted Article: Application of the cellular solids model to Xenopus dorsal isolates reveals that F-actin cortex composition, in the form of F-actin cross-linking, plays a major role in bulk mechanics during neurulation.

Summary: A mechanism is identified in Arabidopsis thaliana that mediates cell cycle modification in response to plant cell wall damage through controlled changes in cytokinin levels.

Highlighted Article: Maternal Ybx1 is an essential translational repressor during zebrafish oocyte maturation and early embryonic development, and its loss leads to abnormal oocyte maturation, egg activation and early embryogenesis.

Summary: Changing lineage contributions of axial progenitors to the developing mouse embryo are revealed using a tamoxifen-inducible Cre line under the control of the endogenous Nkx1-2 promoter.

Summary:Ex vivo and in vivo observations indicate that Trio is a master integrator for factors that guide axonal growth and cell migration, and coordinate telencephalic wiring.

Summary: Single-particle analysis reveals that, in Arabidopsis, FLS2 diffusion in the plasma membrane and FLS2 internalization are altered in a sterol-deficient mutant.

Summary: Proneural genes are well known inducers of neurogenesis; however, Neurog1 induces the expression of Notch pathway genes and represses the expression of neuronal differentiation genes.

Summary: FGF regulates epithelial-mesenchymal transition in mesoderm to support collective movement at gastrulation and also the reverse, mesenchymal-to-epithelial transition, during which cells acquire apicobasal polarity to support their differentiation into diverse muscle types.


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