Issues

Summary: Elly Tanaka discusses how she became interested in regeneration and why the axolotl is such a great model, as well as the importance of giving a voice to the next generation of researchers.

Summary: An overview of Wnt-β-catenin signaling highlighting its key functions during development and adult tissue homeostasis.

Summary: The first SY-Stem meeting in Vienna brought together emerging leaders in stem cell biology, who presented their wide-ranging high-quality research, laying the foundations for dynamic future collaborations.

Summary: Drosophila multi-potent progenitors produce brain region-specific glial populations, including astrocyte-like and ensheathing glia, with Notch signaling promoting the switch to glial fate and subsequent expansion.

Summary: Monkey haploid neural progenitor cells are proliferative and multipotent, yielding a range of neural subtypes that can serve as powerful tools to identify neural toxicant targets via high-throughput genetic screening.

Summary: Appropriate differentiation of pre-osteoblasts into joint cells or osteoblasts during fin regeneration is controlled in part by retinoic acid-dependent regulation of hoxa13a, evx1 and pthlha expression.

Summary: Phenotypic analysis of hobbit mutants reveals that Hobbit is a novel and conserved regulator of body size in Drosophila that plays a specific role in secretory granule membrane protein trafficking.

Highlighted Article: A new ‘clock and scaled gradient’ model of zebrafish somite formation demonstrates that dynamic gradient scaling in the presomitic mesoderm plays a central role in progression and size control of somitogenesis.

Summary: Constitutively active Raf facilitates direct activation of Snail by Zic-r.a, providing a gene circuit shortcut that allows temporal coordination of cellular developmental programs of distinct somatic lineages.

Summary: In Arabidopsis, a regulatory module activated during organ outgrowth tightly links cytoskeleton organization to cell wall remodelling.

Summary: Analysis of temperature-sensitive mutants identifies a novel role for the lipid phosphatase Sac1 in regulating epithelial patterning and microtubule organization during early stages of Drosophila eye development.

Summary: SOX30 plays a key role in round spermatid development and chromocenter formation, and regulates diverse families of protein-coding and lncRNA genes, including Sox30 itself.

Highlighted Article: PI(4,5)P₂ is distributed in dynamic cortical structures and regulates asymmetric division by controlling actin organization as well as cell polarity in the one-cell C. elegans embryo.