Issues
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Cover image
Cover Image
Cover: Central longitudinal section of an Arabidopsis seed, taken from a three-dimensional reconstruction created using the modified pseudo-Schiff propidiumiodide imaging technique. The innermost epidermal integument cell layer is highlighted in yellow whereas the sub-epidermal cell layers are marked in red and green. See Research report by Coen et al. on p. 1490.
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IN THIS ISSUE
CORRESPONDENCE
REVIEWS
Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells
Summary: This Review article summarizes the current state-of-the-art retinal stem cell therapies, and highlights the essential role of developmental biology in moving this field forward.
Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
Summary: This Review article provides a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
HUMAN DEVELOPMENT
The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation
Highlighted Article: Second trimester human chorion, a fetal membrane, contains definitive hematopoietic stem cells capable of engrafting adult immunodeficient mice.
STEM CELLS AND REGENERATION
FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition
Summary: FGF signaling is required for post-gastrula paraxial mesoderm induction through a unique mechanism that differs from its role during gastrula stage mesoderm induction.
Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart
Summary: Three-dimensional confocal imaging reveals changes in cell morphology, behaviour and gene expression during cardiac regeneration following cryoinjury.
The role of variant histone H2AV in Drosophila melanogaster larval hematopoiesis
Summary: A combination of homozygous mutant and RNAi analyses reveal that the variant histone H2AV is required for the normal differentiation of blood cells in Drosophila larval lymph glands.
The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo
Summary: Satb1 regulates the cell fate choice between pluripotency and differentiation in the early mouse embryo and is a downstream target of the Fgf signalling pathway.
Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration
Summary: Neuroepithelial cells are the predominant stem cell type to support cerebellar regeneration after injury in Zebrafish, as opposed to radial glia-like cells, which play a relatively minor role.
RESEARCH REPORTS
MpWIP regulates air pore complex development in the liverwort Marchantia polymorpha
Highlighted Article: The MpWIP gene controls the development of the air pore complex – a multicellular structure that increases CO2 uptake – in the early-diverging land plant Marchantia polymorpha.
Stomach curvature is generated by left-right asymmetric gut morphogenesis
Highlighted Article: Left-right patterning creates morphogenetic differences between the left and right walls of the vertebrate foregut that generate the asymmetric curvature of the stomach.
IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress
Summary: Intracellular Ca2+ signaling regulates protein translation and can compensate for insulin signaling in specialized neuro-hormonal cells, thus enabling Drosophila larval to pupal development under acute starvation.
Developmental patterning of the sub-epidermal integument cell layer in Arabidopsis seeds
Summary: The sub-epidermal integument cell layer of the Arabidopsis seed coat is insensitive to endosperm growth alone and displays a unique response to fertilization.
RESEARCH ARTICLES
Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Highlighted Article: Skin-graft experiments, transcriptional profiling and growth factor treatment demonstrate that estrogen-regulated TGFβ signalling is crucial for the maintenance of the highly specialized nipple epidermis.
Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity
Summary: Loss of expression of zinc-finger transcription factor Nerfin-1 in early-stage medullar neurons activates Notch signaling and promotes neuron-to-neuroblast reversion.
Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation
Summary: A folate receptor-dependent action promotes neural tube formation by facilitating the changes in neural plate cell shape that are required during neurulation.
A systems-level approach reveals new gene regulatory modules in the developing ear
Summary: Transcriptome analysis and knock down of select transcription factors reveals a genetic hierarchy as cells become committed to inner ear fate.
IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture
Summary: IFT56 is key for the integrity and function of intraflagellar transport in cilia, and, consequently, for vertebrate development.
Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis
Summary: Genetic analyses of Esama function in mutant zebrafish embryos reveal specific and redundant functions of Esama and VE-cadherin proteins in endothelial cell recognition and blood vessel morphogenesis.
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Summary: The transcription factor Helios regulates G1-S transition to promote neuronal differentiation of a striatopallidal neuronal subpopulation involved in motor skill acquisition.
CORRECTIONS
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
