IN THIS ISSUE
Summary: This Review article summarizes the current state-of-the-art retinal stem cell therapies, and highlights the essential role of developmental biology in moving this field forward.
Summary: This Review article provides a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
Highlighted Article: Second trimester human chorion, a fetal membrane, contains definitive hematopoietic stem cells capable of engrafting adult immunodeficient mice.
STEM CELLS AND REGENERATION
FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition
Summary: FGF signaling is required for post-gastrula paraxial mesoderm induction through a unique mechanism that differs from its role during gastrula stage mesoderm induction.
Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart
Summary: Three-dimensional confocal imaging reveals changes in cell morphology, behaviour and gene expression during cardiac regeneration following cryoinjury.
Summary: A combination of homozygous mutant and RNAi analyses reveal that the variant histone H2AV is required for the normal differentiation of blood cells in Drosophila larval lymph glands.
Summary: Satb1 regulates the cell fate choice between pluripotency and differentiation in the early mouse embryo and is a downstream target of the Fgf signalling pathway.
Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration
Summary: Neuroepithelial cells are the predominant stem cell type to support cerebellar regeneration after injury in Zebrafish, as opposed to radial glia-like cells, which play a relatively minor role.
Highlighted Article: The MpWIP gene controls the development of the air pore complex – a multicellular structure that increases CO2 uptake – in the early-diverging land plant Marchantia polymorpha.
Highlighted Article: Left-right patterning creates morphogenetic differences between the left and right walls of the vertebrate foregut that generate the asymmetric curvature of the stomach.
IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress
Summary: Intracellular Ca2+ signaling regulates protein translation and can compensate for insulin signaling in specialized neuro-hormonal cells, thus enabling Drosophila larval to pupal development under acute starvation.
Summary: The sub-epidermal integument cell layer of the Arabidopsis seed coat is insensitive to endosperm growth alone and displays a unique response to fertilization.
Highlighted Article: Skin-graft experiments, transcriptional profiling and growth factor treatment demonstrate that estrogen-regulated TGFβ signalling is crucial for the maintenance of the highly specialized nipple epidermis.
Summary: Loss of expression of zinc-finger transcription factor Nerfin-1 in early-stage medullar neurons activates Notch signaling and promotes neuron-to-neuroblast reversion.
Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation
Summary: A folate receptor-dependent action promotes neural tube formation by facilitating the changes in neural plate cell shape that are required during neurulation.
Summary: Transcriptome analysis and knock down of select transcription factors reveals a genetic hierarchy as cells become committed to inner ear fate.
IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture
Summary: IFT56 is key for the integrity and function of intraflagellar transport in cilia, and, consequently, for vertebrate development.
Summary: Genetic analyses of Esama function in mutant zebrafish embryos reveal specific and redundant functions of Esama and VE-cadherin proteins in endothelial cell recognition and blood vessel morphogenesis.
Summary: The transcription factor Helios regulates G1-S transition to promote neuronal differentiation of a striatopallidal neuronal subpopulation involved in motor skill acquisition.