Issues
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Cover image
Cover Image
Cover: A confocal projection (pseudocoloured yellow) of the blood vasculature of a 72 hpf Tg(fli1a:egfp) zebrafish embryo injected with flt1 morpholino. Flt1 suppresses Vegfd and Vegfc signalling, which drives hyperbranching in developing intersegmental arteries. See Research article by Bower et al. on p. 507.
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IN THIS ISSUE
MEETING REVIEW
Trends in tissue repair and regeneration
Summary: This review of a recent EMBO conference draws together emerging themes in regeneration research and highlights the diversity of regeneration strategies in different organ systems and species.
HYPOTHESIS
Formative pluripotency: the executive phase in a developmental continuum
Summary: This Hypothesis article poses that a third state of pluripotency, called formative pluripotency, exists between the naïve and primed states, and is enabling for the execution of pluripotency.
REVIEW
Cellular and molecular mechanisms of tooth root development
Summary: This Review discusses the factors involved in tooth root development and in human root developmental defects, and highlights the role of stem cells in establishing the crown-to-root transition.
STEM CELLS AND REGENERATION
Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex
Summary: During mouse neurogenesis, levels of mitochondrial reactive oxygen species (mtROS) decline during differentiation. Prdm16 and PGC1α are candidate regulators of this metabolic shift.
Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration
Summary: In mouse, mutations in different subunits of the PRC2 complex have specific effects on urothelial progenitor cell proliferation and differentiation.
RESEARCH ARTICLES
The Ectocarpus IMMEDIATE UPRIGHT gene encodes a member of a novel family of cysteine-rich proteins with an unusual distribution across the eukaryotes
Highlighted article: In the brown alga Ectocarpus, the IMMEDIATE UPRIGHT gene encodes a member of the rapidly evolving EsV-1-7 family that regulates early development in the sporophyte generation.
Reciprocal signaling by Wnt and Notch specifies a muscle precursor in the C. elegans embryo
Highlighted article: Generation of muscle from one specific C. elegans 8-cell stage blastomere requires two cell-cell interactions. Notch-induced zygotic MOM-2 (Wnt) is responsible for both interactions.
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development
Highlighted article: The Nan mouse contains a heterozygous mutation in Eklf/Klf1 that ectopically activates misexpressed genes, leading to intrinsic erythroid and systemic developmental deficits.
Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
Summary: Germ cell-specific ablation of the sirtuin Sirt1 causes infertility, due to disruption of the autophagy pathway and consequent defects in acrosome biogenesis.
A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes
Summary: MAPK-mediated phosphorylation and degradation of CPEB1 triggers meiotic cell cycle-coupled translation of dormant maternal mRNAs during oocyte maturation and maternal-zygotic transition.
An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates
Summary: Lineage tracing approaches in zebrafish reveal that intestinal smooth muscle originates from the lateral plate mesoderm. Migration and differentiation of these cells involves TGFβ signaling.
Intrinsic properties of limb bud cells can be differentially reset
Summary: Grafting experiments in chick wing buds show that autopod fate is intrinsically defined, while early but not late autopod cells can adopt host proliferation rates when transplanted into the zeugopod.
The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila
Summary: Genetic epistasis, protein localization and FRET assays reveal the functional organization of the Abl signaling network - a highly conserved and ubiquitous system that controls cell morphology and motility.
The chemical compound bubblin induces stomatal mispatterning in Arabidopsis by disrupting the intrinsic polarity of stomatal lineage cells
Summary: In Arabidopsis, a pyridine-thiazole derivative, bubblin, disrupts polarity in stomatal stem cells, resulting in ectopic retention of the key transcription factor SPEECHLESS and stomatal mispatterning.
Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development
Summary: VEGFD has been considered dispensable for vascular development in vertebrates. Its mutation reveals that Vegfd plays context-specific and compensatory roles during both angiogenesis and lymphangiogenesis.
TECHNIQUES AND RESOURCES
Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos
Summary: A mouse model allowing mosaic expression of wild-type or mutant histone H3.3 variants provides insights into the function of specific histone residues during oogenesis and early development.
PUBLISHER'S NOTE
CORRECTIONS
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register by 28 February 2025 to join us in March 2025 in Liverpool, UK.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.