IN THIS ISSUE
The Zahn drawings: new illustrations of Xenopus embryo and tadpole stages for studies of craniofacial development
Summary: New, freely available illustrations of developing Xenopus laevis, drawn by Natalya Zahn, provide a resource for teaching and research, especially in the field of craniofacial biology.
Summary: This Meeting Review discusses recent progress in our understanding of neuronal programming, highlighting some of the common features of cell fate determination during development and directed reprogramming.
STEM CELLS AND REGENERATION
Summary: Endothelium-derived soluble amyloid precursor protein negatively regulates the growth of neural stem cells to control neural stem cell number in the subventricular zone of the adult mouse brain.
Summary: Bone morphogenetic protein signaling is pivotal for muscle stem cell-dependent postnatal skeletal muscle growth and determination of the final adult muscle stem cell reservoir.
Highlighted article: A simple, transgene-free method is described for resetting human ESCs or iPSCs to a stable naïve status via transient histone deacetylase inhibition.
Highlighted article: A non-classical function of acetylcholinesterase in the polarization, rearrangement and adhesion of endoderm cells during Xenopus gut morphogenesis is identified.
Inwardly rectifying potassium channels influence Drosophila wing morphogenesis by regulating Dpp release
Highlighted article: Calcium transients modulate the temporal dynamics of Dpp presentation in developmental BMP signaling, impacting the downstream transcriptional response and tissue morphogenesis.
Highlighted article: The genome-wide impact of Xist RNA lacking the A-repeat suggests a significant role for Xist in gene regulation beyond imprinted X inactivation.
Summary: Wnt16 signalling acts downstream of mechanical loading to shape developing joints through control of cell division and migration.
Summary: A new model is presented whereby multiple mesodermal tissues and signalling centres, rather than a single organizer, mediate the induction and patterning of chick sensory placodes.
Summary: Lrp4 can act as both inhibitor and activator of the Wnt/β-catenin pathway through interactions with Wise to determine tooth number and patterning in mouse.
Summary: The regulation of somatostatin (SST) and parvalbumin (PV) mouse cortical interneurons is mediated by Coup-TF1- and Coup-TF2-driven Sox6 expression, identifying a transcriptional pathway that controls SST-PV fate.
TECHNIQUES AND RESOURCES
Summary: Genome editing in Xenopus oocytes employing homology-directed repair and DNA ligase inhibition effciently generates non-mosaic mutations with germline transmission.