Issues
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Cover image
Cover Image
Cover: Juvenile crab collected in a plankton tow. This image, taken by Chiara Sinigaglia at the 2015 Woods Hole MBL Embryology Course, was chosen by readers of the Node (http://thenode.biologists.com).
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IN THIS ISSUE
SPOTLIGHTS
The status of the human embryo in various religions
Summary: This Spotlight article briefly describes how several different religions perceive the human embryo, and considers how this might influence their view of human embryological research.
Interspecies chimeras for human stem cell research
Summary: This Spotlight discusses the potential of interspecies chimeras for human stem cell research but also the significant barriers and ethical issues surrounding their generation.
REVIEW
A framework for understanding the roles of miRNAs in animal development
Summary: This Review discusses how different classes of miRNAs fit into the hierarchy of gene regulatory networks that control development, from early embryogenesis to cell differentiation.
STEM CELLS AND REGENERATION
BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice
Summary: A Gli1 transgenic mouse model reveals that BMP signaling regulates mesenchymal stem cell fate during molar root development.
Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia
Summary: In Drosophila, simultaneous loss of Cno and Scrib results in disrupted asymmetric cell division and Ras-PI3K-Akt activation in neuroblasts, and in ectopic Ras-MAPK signaling in epithelia.
Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary
Summary: Integrated and independent activities of the Yki and Hh signaling pathways guide the maintenance, differentiation and proliferation of somatic and germline stem cells of the Drosophila germarium.
RESEARCH ARTICLES
Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish
Highlighted article: Inactivation of Cdk5, or its regulator Cdk5r1a, leads to reduced network branching and disrupts actin organization in the zebrafish adult intrahepatic biliary network.
Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program
Highlighted article: Oocyte-specific knockout of Setd1b in mouse disrupts the zona pellucida, metabolic processes and zygote morphology, identifying Setd1b as a key regulator of oocyte development.
Sin3a regulates epithelial progenitor cell fate during lung development
Highlighted article: Loss of Sin3a in the mouse early foregut endoderm leads to defects in lung development and cell cycle arrest of epithelial progenitor cells.
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development
Summary: Identification of novel enhancers in vertebrate Notch1 genes places SoxF transcription factors directly upstream of Notch signalling in controlling arterial specification and differentiation.
Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina
Summary: Combgap acts as a novel negative regulator of Eya-So in transcriptional outputs that coordinate cell cycle exit with the transition to differentiation during Drosophila retinal development.
Convergence of signaling pathways underlying habenular formation and axonal outgrowth in zebrafish
Summary: Development of dHb neurons and posteriorly directed outgrowth of their axons are regulated by Shh, Wnt, Fgf, and chemokine signaling pathways in zebrafish.
Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex
Summary: The chromatin architectural protein Pita functions much like dCTCF in the organization of Drosophila BX-C, providing insight into how boundaries impact BX-C gene regulation and segment specification.
COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation
Summary: Mutations in the COP9 signalosome component CSN1b promote degradation of the tumor suppressor Capicua, by both a cullin-mediated EGFR-dependent mechanism and by an alternative route.
SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation
Summary: The cilia-related protein SPEF2 is involved in intracellular transport during sperm tail formation via an interaction with cytoplasmic dynein 1, IFT20 and GOLGA3 proteins.
TECHNIQUES AND RESOURCES
A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans
Summary: A simple method to target GFP-tagged proteins for proteasomal degradation enables spatially controlled protein elimination in C. elegans.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
