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Issues

IN THIS ISSUE

MEETING REVIEW

Summary: This Meeting Review of the 2017 RIKEN-CDB Symposium summarises recent progress in our understanding of human development, genetics and our evolutionary history.

REVIEWS

Summary: This Review discusses the mechanisms that underpin the formation of skeletal muscle during development and its recapitulation from pluripotent stem cells in vitro.

Summary: This Review discusses the principal mechanisms involved in thyroid organogenesis, highlighting the factors involved in thyroid progenitor specification and the events occurring during thyroid gland morphogenesis.

STEM CELLS AND REGENERATION

Highlighted Article: Constitutive activation of the MAPK/ERK pathway causes pituitary hyperplasia, abnormal morphogenesis, and abnormal endocrine cell specification due to the sustained proliferation of the Sox2+ stem cell compartment.

RESEARCH ARTICLES

Highlighted Article: Quantitative differences in medial myosin pulse intensity and frequency are critical to distinguish delaminating neuroblasts from their neighbors.

Highlighted Article: KAT8 represses ROS levels in oocytes by promoting the expression of antioxidant genes, while genetic deletion of KAT8 leads to female infertility.

Highlighted Article: Secreted MSPds promote the localization of mitochondria within the body wall muscle during development, with implications for ALS. See also the companion paper by Cottee et al.

Highlighted Article:vpr-1 null mutants are sterile upon hatching, a defect rescued by the expression of MSPd from almost any tissue except for the somatic gonad itself. See also the companion paper by Schultz et al.

Highlighted Article: Btbd7 promotes in vivo branching morphogenesis by decreasing cell-cell adhesion and increasing cell motility in a site-specific manner at the tips of epithelial end buds.

Summary: Experimental data together with computational modeling indicate a novel mechanism by which FGF10 influences fungiform papillae size via non-transcriptional effects on canonical Wnt diffusion.

Summary:Dmrt1 is both necessary and sufficient to initiate testicular differentiation in T. scripta, thereby acting as a key upstream regulator of male development in a TSD system.

Summary: Pgam5 interacts with Dishevelled2 and is essential for head formation, and for establishing and maintaining the Wnt/β-Catenin signaling gradient that patterns the anterior-posterior body axis in Xenopus laevis.

Summary: Svb and SoxN activate overlapping sets of structural genes that orchestrate denticle formation and control the precise shaping of epidermal cell structures in the Drosophila embryo.

Summary: ZERZAUST acts in a non-cell-autonomous manner and is required for cell wall organization during tissue morphogenesis, while zerzaust mutants show defects in cell wall composition.

Summary: A combination of biochemical and functional experiments demonstrate that p38 function is not required for dorsal-ventral axis formation and skeletogenesis, as was previously believed.

Summary: RET-mediated GDNF signaling in the urogenital sinus increases proliferation of urethral mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells.

Summary: Deletion of Sox9 in the salivary gland epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching in mice.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

From Journal of Cell Science

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