IN THIS ISSUE
Summary: This Review discusses the mechanisms that underpin the formation of skeletal muscle during development and its recapitulation from pluripotent stem cells in vitro.
STEM CELLS AND REGENERATION
MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma
Highlighted Article: Constitutive activation of the MAPK/ERK pathway causes pituitary hyperplasia, abnormal morphogenesis, and abnormal endocrine cell specification due to the sustained proliferation of the Sox2+ stem cell compartment.
Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts
Highlighted Article: Quantitative differences in medial myosin pulse intensity and frequency are critical to distinguish delaminating neuroblasts from their neighbors.
Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels
Highlighted Article: KAT8 represses ROS levels in oocytes by promoting the expression of antioxidant genes, while genetic deletion of KAT8 leads to female infertility.
The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1
Highlighted Article: Secreted MSPds promote the localization of mitochondria within the body wall muscle during development, with implications for ALS. See also the companion paper by Cottee et al.
Highlighted Article: vpr-1 null mutants are sterile upon hatching, a defect rescued by the expression of MSPd from almost any tissue except for the somatic gonad itself. See also the companion paper by Schultz et al.
Highlighted Article: Btbd7 promotes in vivo branching morphogenesis by decreasing cell-cell adhesion and increasing cell motility in a site-specific manner at the tips of epithelial end buds.
Summary: Experimental data together with computational modeling indicate a novel mechanism by which FGF10 influences fungiform papillae size via non-transcriptional effects on canonical Wnt diffusion.
Summary: Dmrt1 is both necessary and sufficient to initiate testicular differentiation in T. scripta, thereby acting as a key upstream regulator of male development in a TSD system.
The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning
Summary: Pgam5 interacts with Dishevelled2 and is essential for head formation, and for establishing and maintaining the Wnt/β-Catenin signaling gradient that patterns the anterior-posterior body axis in Xenopus laevis.
SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila
Summary: Svb and SoxN activate overlapping sets of structural genes that orchestrate denticle formation and control the precise shaping of epidermal cell structures in the Drosophila embryo.
The cell wall-localized atypical β-1,3 glucanase ZERZAUST controls tissue morphogenesis in Arabidopsis thaliana
Summary: ZERZAUST acts in a non-cell-autonomous manner and is required for cell wall organization during tissue morphogenesis, while zerzaust mutants show defects in cell wall composition.
p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation
Summary: A combination of biochemical and functional experiments demonstrate that p38 function is not required for dorsal-ventral axis formation and skeletogenesis, as was previously believed.
RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development
Summary: RET-mediated GDNF signaling in the urogenital sinus increases proliferation of urethral mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells.
Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development
Summary: Deletion of Sox9 in the salivary gland epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching in mice.