IN THIS ISSUE
Summary: This Review discusses the developmental processes underlying Notch-related congenital disorders in humans, drawing on data from model organisms and genome-sequencing projects.
A small-molecule screen reveals that HSP90β promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover
Highlighted Article: The heat shock protein HSP90β regulates the half-life of HNF4A and is necessary for efficient differentiation of hepatocytes from human iPSCs.
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
Summary: Human endometrium organoids replicate the menstrual cycle in response to hormone treatment, while mouse endometrium organoid type is determined by variations in WNT.
STEM CELLS AND REGENERATION
Summary: Network analysis during appendage regeneration in Ciona robusta predicts the importance of, the relationship between and the regulation of numerous gene functional categories during this process.
Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation
Highlighted Article: Segregation of the germ layer progenitors in the zebrafish gastrula is driven by directed cell migration, rather than differential tissue surface tension.
Highlighted Article: A non-cell-autonomous mechanism regulates inhibitory neuron synapse formation at the neuromuscular junction.
Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome
Summary: Maternal inheritance of a mutation to block RNA elongation through KvDMR1 results in an absence of DNA methylation at KvDMR1, biallelic expression of Kcnq1ot1 and suppression of maternally expressed genes.
Reciprocal proteasome-mediated degradation of PIFs and HFR1 underlies photomorphogenic development in Arabidopsis
Summary: Reciprocal degradation of PIFs and HFR1 highlights a novel mechanism by which HLH factors regulate the abundance of bHLH factors to optimize photomorphogenesis in Arabidopsis.
Dose-dependent transduction of Hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor Smoothened and the kinase Fused
Summary: A SMO/FU positive regulatory loop nested within a multikinase phosphorylation cascade regulates high level Hedgehog signaling in the Drosophila wing imaginal disc.
Summary: Double knockout of Rac1 and Rac3 in cerebellar granule neurons impairs their tangential migration and final differentiation. Rac depleted cells exhibit decreased levels of Mid1 and impaired mTORC1 signaling.
Summary: A combination of experimental work and theory reveals how gradients in transcription, signaling and resulting contractility shape tissue folding.
Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types
Summary: The Sox18Op/+ mutation in mice, which mimics a hair loss condition in humans, leads to decreasing Wnt signal interactions with the hair follicle epidermis and abnormal hair follicle morphology.
Summary: A detailed analysis of posterior segment addition in an insect reveals that the growth zone is divided into two functional domains responsible for growth and differentiation.
Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia
Summary: Sox17 haploinsufficiency in the gallbladder induces ectopic cystic duct-like epithelia and defective smooth muscle formation by reduced Shh signals.