IN THIS ISSUE
Summary: This Primer discusses the bi-functional ‘coding and non-coding’ class of RNAs, known as cncRNAs, and reviews their roles, regulation and mechanisms of action during development.
Summary: This Review summarises the different stem cell populations that have been described in the adult mammalian heart, as well their developmental origin and lineage potential both in vivo and in vitro.
Summary: This Review summarises the transcription factor and epigenetic control of stomatal development and patterning, highlighting similarities between plant and animal developmental mechanisms.
STEM CELLS AND REGENERATION
The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo
Summary: Associations of BAF155 with other BAF complex subunits are enriched in extra-embryonic lineages prior to implantation, while changes in BAF155 levels modulate the expression of early developmental markers.
Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver
Summary: A quantitative approach reveals how the pre-HSC pool undergoes dramatic growth in the AGM region and, by E11.5, reaches the size that matches the number of definitive HSCs in the E12.5 foetal liver.
Gene expression profiles uncover individual identities of gnathal neuroblasts and serial homologies in the embryonic CNS of Drosophila
Highlighted article: Characterisation of the neural stem cells in the gnathal head region completes the mapping of all individual neuroblasts that generate the Drosophila CNS.
Summary: A new model for understanding the earliest steps of hematopoiesis is based on the in vitro recapitulation of hemogenic endothelium commitment from quail pre-somitic mesoderm.
A shared role for sonic hedgehog signalling in patterning chondrichthyan gill arch appendages and tetrapod limbs
Summary: Shh signalling polarises skate gill arches and maintains proliferative expansion of gill arch appendage endoskeletal progenitors, mirroring the function of Shh signalling in the tetrapod limb.
Highlighted article: Live imaging of mural cell dynamics in zebrafish shows how the mural cells develop and cover the endothelial cells during vascular development.
Highlighted article: A network of embryonic genes, many of which are expressed in the mesoderm and the organiser, can initiate transcription through a non-canonical mechanism.
Dendritic diversification through transcription factor-mediated suppression of alternative morphologies
Highlighted article: Interactions among Cut, Pdm1/2, Scalloped and Vestigial transcription factors control cell type-specific dendrite morphogenesis in Drosophila sensory neurons.
Summary: A novel role for the Cdx proteins at the top of the trunk neural crest gene regulatory network is revealed via a neuroectoderm-directed functional knockdown approach in mouse.
Summary: Contraction of the ovarian muscles helps to produce the elongated shape of the Drosophila egg by stimulating yolk uptake by the oocyte.
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium
Summary: α-Spectrin and integrins regulate apical constriction-independent cell elongation, identifying a primary role for α-Spectrin in controlling cell shape.
Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis
Summary: Novel roles are uncovered for centromere assembly factors CENP-C and CAL1 in meiotic chromosome segregation, CENP-A assembly and maintenance of sperm, as well as fertility in Drosophila males.
The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila
Summary: The transcription factor Glass functions downstream of Sine oculis to activate the expression of phototransduction proteins via its direct target, Hazy.
Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism
Summary: ZFP36L3-deficient mice have fewer offspring than normal and increased placental expression of many potential target genes, including genes essential for placenta function.