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Issues

IN THIS ISSUE

SPOTLIGHTS

Summary: Developmental biologist Cheryll Tickle chats about her research, the new British Society for Developmental Biology medal awarded in her honour and how the field has changed during her career.

Summary: Abigail Tucker, winner of the first Cheryll Tickle Medal, discusses her research on craniofacial development and the challenges and rewards of working with emerging model systems.

REVIEWS

Summary: This Review discusses recent advances in live imaging, computational modelling and single cell analyses that provide insights into how the first three cell lineages of the mouse embryo are generated.

Summary: This Review discusses the extent to which astrocytes in different brain regions can behave as neural stem cells, and the molecular and environmental factors that either promote or repress such activity.

STEM CELLS AND REGENERATION

Summary: In the vertebrate eye, dorsally expressed Gdf6a limits RA pathway activity to control the transition from proliferation to differentiation, thereby regulating eye size.

Summary: A quantitative study of cell proliferation and fate choice in the zebrafish retina - a continuously growing neural tissue - reveals key features of late retinal neurogenesis.

Summary: ULT1 and its novel partner protein ULT1 INTERACTING FACTOR 1 (UIF1) regulate floral meristem homeostasis, probably via direct repression of WUS expression.

RESEARCH REPORT

Summary: The well-known correlation between ploidy and cell volume in the leaf epidermis is not seen in leaf palisade mesophyll cells, indicating that cell identity influences this correlation.

RESEARCH ARTICLES

Highlighted article: New mouse models reveal that human disease-causing mutations in the β-tubulin gene Tubb5 lead to defects in mitotic progression and massive cell death in the cortex.

Highlighted article: The cancer-associated protein Tctp controls neural circuitry in Xenopus via its regulation of pro-survival signalling and axonal mitochondrial homeostasis.

Highlighted article: A retrospective clonal analysis of mouse liver development reveals progressive developmental restriction, the acquisition of chirality and distinct cell growth behaviors.

Summary: During Drosophila sensory organ development, G2-phase arrest serves a dual role: it prevents progenitor self-renewal and it synchronizes cell division with developmental signals.

Summary: Clonal analyses of the origins and organization of astrocytes in the Drosophila CNS reveal a regulatory program that acts as a binary switch to distinguish astrocytes from other glial cells.

Summary: The C. elegans EFN-4 ephrin acts as a soluble factor to direct axon guidance via LAD2, a divergent L1 cell adhesion molecule that probably functions as a non-canonical receptor for EFN-4.

Summary: The transcription factor Grhl2 activates novel EMT suppressors along with epithelial junctional proteins to robustly promote epithelial integrity during neural tube closure in mice.

Summary: Increased RA levels in developing zebrafish have multiple effects on skull formation, ranging from gain to loss of bone, and depending on allelic strength, developmental stage and cellular context.

TECHNIQUES AND RESOURCES

Summary: Using laser capture micro-dissection followed by array hybridization, the temporal and spatial gene expression changes occurring during rice embryogenesis are captured.

CORRECTIONS

ARTICLES OF INTEREST IN OTHER COB JOURNALS

From Journal of Cell Science

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