Issues
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Cover image
Cover Image
Cover: A segmented brain MRI scan for a heterozygous Tubb5 knockout mouse. Depicted are the olfactory bulbs (yellow), cortex (cyan), putamen (dark blue), lateral ventricles (red), hippocampus (green), colliculi (maroon) and cerebellum (pink). These mice have microcephaly reminiscent of patients with TUBB5 mutations. See Research article by Breuss et al. on p. 1126.
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IN THIS ISSUE
SPOTLIGHTS
An interview with Cheryll Tickle
Summary: Developmental biologist Cheryll Tickle chats about her research, the new British Society for Developmental Biology medal awarded in her honour and how the field has changed during her career.
An interview with Abigail Tucker
Summary: Abigail Tucker, winner of the first Cheryll Tickle Medal, discusses her research on craniofacial development and the challenges and rewards of working with emerging model systems.
REVIEWS
Lineage specification in the mouse preimplantation embryo
Summary: This Review discusses recent advances in live imaging, computational modelling and single cell analyses that provide insights into how the first three cell lineages of the mouse embryo are generated.
Stars from the darkest night: unlocking the neurogenic potential of astrocytes in different brain regions
Summary: This Review discusses the extent to which astrocytes in different brain regions can behave as neural stem cells, and the molecular and environmental factors that either promote or repress such activity.
STEM CELLS AND REGENERATION
Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
Summary: In the vertebrate eye, dorsally expressed Gdf6a limits RA pathway activity to control the transition from proliferation to differentiation, thereby regulating eye size.
The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue
Summary: A quantitative study of cell proliferation and fate choice in the zebrafish retina - a continuously growing neural tissue - reveals key features of late retinal neurogenesis.
The Myb-domain protein ULTRAPETALA1 INTERACTING FACTOR 1 controls floral meristem activities in Arabidopsis
Summary: ULT1 and its novel partner protein ULT1 INTERACTING FACTOR 1 (UIF1) regulate floral meristem homeostasis, probably via direct repression of WUS expression.
RESEARCH REPORT
The coordination of ploidy and cell size differs between cell layers in leaves
Summary: The well-known correlation between ploidy and cell volume in the leaf epidermis is not seen in leaf palisade mesophyll cells, indicating that cell identity influences this correlation.
RESEARCH ARTICLES
Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis
Highlighted article: New mouse models reveal that human disease-causing mutations in the β-tubulin gene Tubb5 lead to defects in mitotic progression and massive cell death in the cortex.
Tumor protein Tctp regulates axon development in the embryonic visual system
Highlighted article: The cancer-associated protein Tctp controls neural circuitry in Xenopus via its regulation of pro-survival signalling and axonal mitochondrial homeostasis.
Progressive developmental restriction, acquisition of left-right identity and cell growth behavior during lobe formation in mouse liver development
Highlighted article: A retrospective clonal analysis of mouse liver development reveals progressive developmental restriction, the acquisition of chirality and distinct cell growth behaviors.
G2 phase arrest prevents bristle progenitor self-renewal and synchronizes cell division with cell fate differentiation
Summary: During Drosophila sensory organ development, G2-phase arrest serves a dual role: it prevents progenitor self-renewal and it synchronizes cell division with developmental signals.
Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch
Summary: Clonal analyses of the origins and organization of astrocytes in the Drosophila CNS reveal a regulatory program that acts as a binary switch to distinguish astrocytes from other glial cells.
EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans
Summary: The C. elegans EFN-4 ephrin acts as a soluble factor to direct axon guidance via LAD2, a divergent L1 cell adhesion molecule that probably functions as a non-canonical receptor for EFN-4.
Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure
Summary: The transcription factor Grhl2 activates novel EMT suppressors along with epithelial junctional proteins to robustly promote epithelial integrity during neural tube closure in mice.
Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development
Summary: Increased RA levels in developing zebrafish have multiple effects on skull formation, ranging from gain to loss of bone, and depending on allelic strength, developmental stage and cellular context.
TECHNIQUES AND RESOURCES
Genome-wide analysis of spatiotemporal gene expression patterns during early embryogenesis in rice
Summary: Using laser capture micro-dissection followed by array hybridization, the temporal and spatial gene expression changes occurring during rice embryogenesis are captured.
CORRECTIONS
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
