Issues
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Cover image
Cover Image
Cover: Actin filaments (red) are enriched at the borders of enveloping layer cells surrounding the blastoderm (nuclei, blue), in the yolk cell cortex, and in a band adjacent to the blastoderm, where they function in cell movements of epiboly and maintain integrity of the blastoderm and yolk cell, a process that is disturbed in zebrafish split top embryos. See Research article by Langdon et al. on p. 1016.
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IN THIS ISSUE
EDITORIAL
Closing the circle: from organoids back to development
Summary: This Editorial looks at the emerging field of in vitro organogenesis and discusses how organoid technology can be applied to better understand developmental processes.
SPOTLIGHT
An interview with Melissa Little
Summary: Melissa Little chats about her research and career, the potential of the organoid and stem cell fields, and what she hopes to achieve during her guest editorship with Development.
REVIEWS
From single genes to entire genomes: the search for a function of nuclear organization
Summary: This Review highlights the genome-wide techniques used to shed light on the mechanisms of genome folding and unravel the regulatory functions of nuclear organization.
Development of the lymphatic system: new questions and paradigms
Summary: This Review discusses the molecular mechanisms controlling lymphatic system development and highlights findings that shed light on previously uncharacterised sources of lymphatic endothelial cells.
STEM CELLS AND REGENERATION
GATA4 regulates Fgf16 to promote heart repair after injury
Highlighted article: GATA4 and FGF16 are important mediators of cardiomyocyte proliferation and hypertrophy during neonatal heart repair following cryoinjury and apex resection.
The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis
Highlighted article: The developmental transcription factor SOX6 is a positive regulator of adipogenesis in vertebrates and is associated with the fetal origins of human obesity.
H19 controls reactivation of the imprinted gene network during muscle regeneration
Summary: Expression of H19 regulates muscle stem cell number and controls their entry into quiescence. Absence of H19 leads to better muscle regeneration with increased expression of the IGN genes.
RESEARCH REPORTS
Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila
Summary: Mud/NuMA/LIN-5 is a signal transduction component, potentially acting downstream of Frizzled to mediate netrin-independent axon guidance towards the midline.
Control of patterns of symmetric cell division in the epidermal and cortical tissues of the Arabidopsis root
Summary: Adjacent tissues have different requirements for the precise positioning of the division plane, which is mediated at the intracellular level by the preprophase band that controls the pattern of cell division.
RESEARCH ARTICLES
Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration
Highlighted article: The MAPK pathway is necessary and sufficient for generating a group of highly motile epithelial cells whose collective migration drives mammary ductal elongation.
Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point
Summary: Calsyntenin 1 and RabGDI contribute to cargo-specific vesicle trafficking in axonal pathfinding, leading to tightly regulated surface expression of guidance receptors at choice points.
20-hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting
Summary: Steroid hormone 20E upregulates PTEN expression to inhibit insulin-induced Akt and FoxO phosphorylation, resulting in non-phosphorylated FoxO nuclear localisation.
Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
Summary: A zebrafish maternal-effect mutant split top reveals a novel function for the lysosomal endopeptidase cathepsin B in dorsoventral axial patterning and early embryonic morphogenesis.
Reelin and cofilin cooperate during the migration of cortical neurons: a quantitative morphological analysis
Summary: In utero electroporation coupled with real-time imaging reveals that actin cytoskeleton dynamics during neuronal migration are controlled by the cooperation of reelin and cofilin.
Wnt/β-catenin signaling enables developmental transitions during valvulogenesis
Summary: Wnt/β-catenin signaling enables subsequent instructive signaling events that ensure progressive stages of heart valve development unfold in a coordinated manner.
CORRECTIONS
Reck enables cerebrovascular development by promoting canonical Wnt signaling
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
