IN THIS ISSUE
Summary: This Review article discusses the cellular and molecular mechanisms that control cardiomyocyte proliferation, during both heart development and regeneration across various species.
Summary: This Review article provides a comparative view of neuronal repair across vertebrate species, with a particular focus on the molecular pathways that enable repair in some, but not all animals.
STEM CELLS AND REGENERATION
Highlighted article: Manipulating expression of the transcription factor Chinmo in Drosophila gonads shows that sexual identity can be reprogrammed, and must be actively maintained throughout life.
Summary: In the mouse airway epithelium, regeneration after injury involves transient downregulation of BMP signaling to promote proliferation, followed by cell shedding to restore cell density.
Summary: In the developing mouse anterior second heart field, the transcription factor MEF2C directly controls expression of the Nodal co-receptor Cripto to regulate outflow tract alignment.
Summary: Gata4 and Gata6 regulate mouse foregut endoderm patterning via control of hedgehog signaling. In their absence, the pancreatic anlage is respecified to intestinal and stomach fates.
Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest
Highlighted article: In trophoblast progenitor cells, the transcription factor TFAP2C regulates proliferation and differentiation. Tfap2c mutant mice provide a model of intrauterine growth retardation.
Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans
Highlighted article: The C. elegans Makorin homolog lep-2 is a heterochronic gene required for the proper timing of the juvenile-to-adult transition. It acts in the LIN-28/let-7 pathway.
Highlighted article: Cardiac-specific depletion of the H3K4 methyltransferase KMT2D causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.
Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion
Summary: A radical/lunatic fringe chimeric allele predicted to affect protein secretion disrupts segmentation clock function and somite patterning with context-dependent effects.
Summary: In Xenopus, Lhx9, a LIM homeodomain protein, acts upstream of integrin-paxillin signaling to control positioning and migration of proepicardial cells, and subsequent epicardium formation.
Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter
Summary: Defining and patterning cell fate in the mouse cochlea depends on integration of developmental signals at highly conserved regions of the Atoh1 promoter.
The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1
Summary: In C. elegans, depletion of the histone demethylase rbr-2 leads to axon guidance defects that can be attributed to NURF-mediated ectopic expression of the actin regulator wsp-1.
A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators
Summary: Maternally deposited Bicaudal-C, an RNA-binding protein, controls Xenopus early embryonic patterning by repressing translation of cell fate regulators, including Wnt11b.
Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis
Summary: The endothelial versus myogenic fate choice in the somite requires Foxc1/2. In conditional Foxc1/2 mutants, endothelial cell loss compromises migration of myogenic cells to the limb.
Summary: Neurogenesis at advanced embryonic stages, during the gliogenic phase of spinal cord development, generates neurons of the central canal.
Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster
Summary: During Drosophila cellularization, the GTPase Rab8 guides the targeting of cytoplasmic membrane stores to the cell surface through interactions with the exocyst complex.