Issues
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Cover image
Cover Image
Cover: Differing Six2/SIX2 transcriptional networks in mouse and human kidney. E15.5 mouse kidney next to a 15.5 week human fetal kidney with Six2/SIX2 (cyan) marking the nephron progenitors and cytokeratin (red) highlighting the collecting duct system. Nuclei are in blue. See Research article by O'Brien et al. on p. 595.
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IN THIS ISSUE
MEETING REVIEW
The Notch meeting: an odyssey from structure to function
Summary: This Meeting Review summarises the key advances presented at The Notch IX meeting, which was held in Athens, Greece, in October 2015.
REVIEW
Stomach development, stem cells and disease
Summary: This Review highlights the molecular mechanisms of stomach development and discusses recent findings regarding stomach stem cells and organoid cultures, and their roles in investigating stomach diseases.
STEM CELLS AND REGENERATION
Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture
Summary: The entire spermatogenesis process is successfully recapitulated in culture using zebrafish testicular hyperplasias that accumulate early stage spermatogonia.
RESEARCH REPORTS
The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina
Highlighted article: LGN inactivation in mice disrupts spindle orientation in both the retina and neocortex but leads to very different outcomes with regards to cell fate in each context.
Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations
Summary: SDF1/CXCR4 signaling lies downstream of Tbx1 during pharyngeal neural crest development, and inactivating CXCR4 causes defects that phenocopy the human DiGeorge syndrome.
Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells
Summary: Endothelial cells produce Sema3A, a known axon repellent, that exerts repelling functions on VEGF-A-induced tip cell filopodia during angiogenesis in mice.
RESEARCH ARTICLES
Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators
Highlighted article: A comparison of Six2/SIX2 regulatory targets in mouse and human nephron progenitors reveals that Six1/SIX1 is differentially regulated and expressed between the two species.
Cannabinoid receptor signaling regulates liver development and metabolism
Highlighted article: The cannabinoid receptors Cnr1 and Cnr2 are required for normal hepatocyte proliferation and differentiation during zebrafish development, and for normal liver metabolism in adult zebrafish.
Modulation of junction tension by tumor suppressors and proto-oncogenes regulates cell-cell contacts
Highlighted article: Time-lapse imaging studies to follow cell behavior and dynamics in Drosophila epithelia reveal mechanical roles for tumor suppressors and proto-oncogenes.
Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development
Summary: The developmental potential of embryos fertilized with sperm from germline-specific Dicer or Drosha conditional knockout mice is impaired, highlighting key roles for paternal miRNAs/endo-siRNAs.
Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
Summary: During bone formation in neonatal mice, chondrocytic expression of the receptor tyrosine kinase Ephrin B2 regulates cartilage degradation and subsequent osteoclastic destruction of the cartilage matrix.
Inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ signaling mediates delayed myogenesis in Duchenne muscular dystrophy fetal muscle
Summary: The absence of dystrophin in human fetal muscle alters IP3 signaling pathways and consequently causes a delay in myogenesis and myofiber commitment.
Epithelial stratification and placode invagination are separable functions in early morphogenesis of the molar tooth
Summary: During tooth development in mice, FGF-dependent vertical cell divisions thicken the tooth placode while Shh drives cell rearrangements that cause invagination.
NO FLOWERING IN SHORT DAY (NFL) is a bHLH transcription factor that promotes flowering specifically under short-day conditions in Arabidopsis
Summary: The transcription factor NFL acts via the GA pathway and is necessary for promoting flowering in Arabidopsis under non-inductive short-day conditions.
Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development
Summary: Analyses of the mDA neuron marker genes Pitx3 and Aldh1a1 in chick and mouse suggest important differences in how mDA neurons are generated in these species.
RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins
Summary: A screen identifies skeletal patterning factors, including a sulfate transporter, and suggests that ventral proteoglycan sulfation acts as a positional cue during sea urchin skeletal patterning.
Molecular model for force production and transmission during vertebrate gastrulation
Summary: The analysis of actomyosin and C-cadherin dynamics in Xenopus embryos suggests a multistep model to explain how cell intercalation can occur against a force gradient to drive axial extension.
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
