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Summary: The analysis of Shh signaling, Fgf8 signaling and Bmp4 expression dynamics in cavefish embryos reveals subtle modifications in these pathways that lead to a change in lens versus olfactory fate.

Highlighted article: AP-1 activates the expression of vascular genes in hemogenic endothelial cells and is required for de novo binding of the Hippo signaling transcription factor TEAD4.

Summary: This Hypothesis article poses that EMT and collective migration can be viewed as extreme cases of a general continuum, with cells displaying arrays of epithelial and mesenchymal features, and migratory behaviours.

Summary: CRF2, CRF3 and CRF6 are required to regulate PIN1 expression in the inflorescence and this regulation is necessary for correct pistil elongation and ovule number.

Highlighted article: Perturbation of syndecan 4 in mouse embryos reveals a new mechanism of fluid shear stress-mediated signaling involving syndecan 4-dependent upregulation of the PCP protein Vangl2.

Summary: During cucumber female flower development, ovaries produce the gibberellin precursor GA9, which is translocated to the sepal/petals and converted into bioactive GA4.

Summary: In developing Drosophila wings, the apical determinant Crumbs stabilises the Notch receptor on apical membranes via direct interaction between their extracellular domains.

Summary: The analysis of chromatin landscapes, complemented by a machine learning approach, identifies active promoters and enhancers in Drosophila cardiomyocytes, including many new enhancers and their associated transcription factor motifs.

Summary: Loss of filamin and formin causes multiple developmental defects, highlighting roles for these two proteins in Wnt signaling, Lrp6 endocytosis, Gsk3 activation and target gene expression.

Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.

Highlighted article: In mouse hemogenic endothelium, SOX7 inhibits the expression of RUNX1 target genes by directly interacting with RUNX1 and inhibiting its transcriptional activity.

Summary: The histone demethylase IBM1 regulates Arabidopsis stomatal development by suppressing DNA methylation on the gene body region of ERECTA receptors.

Summary: A broad repertoire of conventional human ESCs and transgene-independent iPSC lines can be reverted to stable naive states using WNT, MEK/ERK and tankyrase inhibition.

Highlighted article: Novel optimized inducible knockdown and knockout platforms are developed and used to assess gene function in human pluripotent stem cells and their differentiated progeny.

Summary: The fecundity of unisexual whiptail lizards is similar to bisexual relatives despite pseudo-tetraploid oocytes being exceedingly rare and diploid oocytes failing to proceed past the pairing stage of meiosis.

Summary: Dorsal raphe neurons in mice exhibit functionally significant heterogeneity that is established early during their differentiation via the actions of Gata2 and Gata3.

Summary: Elav – the canonical Drosophila marker for post-mitotic neurons – has a previously unrecognized component of ubiquitous expression that is suppressed by the microRNA pathway, including by miR-279/996.

Summary: Analysis of a hypomorphic Six3 allele reveals that variability in Six3 dosage is sufficient to generate mice exhibiting a spectrum of holoprosencephaly forms in a non-strain-specific manner.

Summary: Adult c-KIT+ olfactory basal stem cells may be propagated as expansion-competent BMI1+ progenitors in culture and provide insight into olfactory homeostasis.

Highlighted article: Phenotypic variation in zebrafish mef2ca mutants is due to cells switching fate, from ligament to bone, possibly as a result of variable transposon epigenetic silencing.

Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.

Summary: Progenitor cells isolated from different regions of the inner ear show distinct capacities for differentiation, acquiring phenotypic properties of their respective compartments of origin.

Summary: Osteoblast specification requires regulatory inputs from BMP2 at the Runx2/Osx1 transition by a mechanism that is not compensated for by canonical Wnt signaling and involves Grhl3.

Summary: David McClay – recipient of the 2016 Society for Developmental Biology Lifetime Achievement Award – talks to us about his career, his research with sea urchins, and his thoughts on mentorship.

IN THIS ISSUE

SPOTLIGHT

Summary: David McClay – recipient of the 2016 Society for Developmental Biology Lifetime Achievement Award – talks to us about his career, his research with sea urchins, and his thoughts on mentorship.

HYPOTHESIS

Summary: This Hypothesis article poses that EMT and collective migration can be viewed as extreme cases of a general continuum, with cells displaying arrays of epithelial and mesenchymal features, and migratory behaviours.

REVIEW

Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.

STEM CELLS AND REGENERATION

Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.

Highlighted article: AP-1 activates the expression of vascular genes in hemogenic endothelial cells and is required for de novo binding of the Hippo signaling transcription factor TEAD4.

Highlighted article: In mouse hemogenic endothelium, SOX7 inhibits the expression of RUNX1 target genes by directly interacting with RUNX1 and inhibiting its transcriptional activity.

Summary: Osteoblast specification requires regulatory inputs from BMP2 at the Runx2/Osx1 transition by a mechanism that is not compensated for by canonical Wnt signaling and involves Grhl3.

Summary: A broad repertoire of conventional human ESCs and transgene-independent iPSC lines can be reverted to stable naive states using WNT, MEK/ERK and tankyrase inhibition.

Summary: Progenitor cells isolated from different regions of the inner ear show distinct capacities for differentiation, acquiring phenotypic properties of their respective compartments of origin.

Summary: Adult c-KIT+ olfactory basal stem cells may be propagated as expansion-competent BMI1+ progenitors in culture and provide insight into olfactory homeostasis.

Highlighted article: Novel optimized inducible knockdown and knockout platforms are developed and used to assess gene function in human pluripotent stem cells and their differentiated progeny.

RESEARCH REPORTS

Summary: CRF2, CRF3 and CRF6 are required to regulate PIN1 expression in the inflorescence and this regulation is necessary for correct pistil elongation and ovule number.

Summary: During cucumber female flower development, ovaries produce the gibberellin precursor GA9, which is translocated to the sepal/petals and converted into bioactive GA4.

RESEARCH ARTICLES

Highlighted article: Phenotypic variation in zebrafish mef2ca mutants is due to cells switching fate, from ligament to bone, possibly as a result of variable transposon epigenetic silencing.

Highlighted article: Perturbation of syndecan 4 in mouse embryos reveals a new mechanism of fluid shear stress-mediated signaling involving syndecan 4-dependent upregulation of the PCP protein Vangl2.

Summary: The histone demethylase IBM1 regulates Arabidopsis stomatal development by suppressing DNA methylation on the gene body region of ERECTA receptors.

Summary: Analysis of a hypomorphic Six3 allele reveals that variability in Six3 dosage is sufficient to generate mice exhibiting a spectrum of holoprosencephaly forms in a non-strain-specific manner.

Summary: Elav – the canonical Drosophila marker for post-mitotic neurons – has a previously unrecognized component of ubiquitous expression that is suppressed by the microRNA pathway, including by miR-279/996.

Summary: The fecundity of unisexual whiptail lizards is similar to bisexual relatives despite pseudo-tetraploid oocytes being exceedingly rare and diploid oocytes failing to proceed past the pairing stage of meiosis.

Summary: Dorsal raphe neurons in mice exhibit functionally significant heterogeneity that is established early during their differentiation via the actions of Gata2 and Gata3.

Summary: Loss of filamin and formin causes multiple developmental defects, highlighting roles for these two proteins in Wnt signaling, Lrp6 endocytosis, Gsk3 activation and target gene expression.

Summary: The analysis of Shh signaling, Fgf8 signaling and Bmp4 expression dynamics in cavefish embryos reveals subtle modifications in these pathways that lead to a change in lens versus olfactory fate.

Summary: The analysis of chromatin landscapes, complemented by a machine learning approach, identifies active promoters and enhancers in Drosophila cardiomyocytes, including many new enhancers and their associated transcription factor motifs.

Summary: In developing Drosophila wings, the apical determinant Crumbs stabilises the Notch receptor on apical membranes via direct interaction between their extracellular domains.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

From Journal of Cell Science
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