Issues

Summary: This Review discusses how stem and progenitor cells contribute to intestinal homeostasis and regeneration, and how they are regulated by different signaling pathways and systemic signals.

Summary: This Review discusses the derivation and differentiation of TSCs, highlighting the signalling cascades and transcription factor circuits that govern TSC self-renewal and differentiation.

Summary: FGF/ERK signaling controls the formation of the mouse inferior colliculus by maintaining a neural progenitor zone and by regulating cell survival, polarity and specification.

Summary: Forced expression of the catalytic domain of JMJD3 together with lineage-defining transcription factors can dramatically accelerate the differentiation of human PSCs.

Highlighted Article: Glucocorticoid receptor and STAT3 signalling act in parallel, but cross-regulated, pathways to control epithelial differentiation during lung alveolar development in mice.

Highlighted Article: Somatic progenitor cell populations in the mouse testis are defined by progressive lineage-specific acquirement of WT1, HES1, SOX9 and GLI1 beginning at the time of sex determination.

Highlighted Article: The transcription factor YY1 plays a key role during intestinal morphogenesis in mice, affecting villi morphogenesis and the expression of mitochondrial genes.

Highlighted Article: Comparative chromatin analyses of purified cell populations and whole embryos, combined with analyses of existing datasets, allow the identification of functional enhancers.

Summary: The PRC component Ezh2 acts cell-autonomously in the developing mouse lung mesothelium to repress smooth muscle differentiation and allow appropriate cell fate decisions to occur.

Summary: Analyses of Drosophila BMP ligands suggest that structural changes based on N-glycosylation motifs are subject to evolutionary constraints and can impact developmental processes.

Summary: The catalytic activity of the histone demethylase RBR-2 is required for cell fate determination in C. elegans and for regulating the epigenetic signature of enhancers and promoters.

Summary: During hypothalamus development in mice, Isl1 is expressed in several subpopulations of developing arcuate neurons and plays crucial roles in specifying their cell fate.

Summary: During Drosophila embryonic CNS development, the zinc-finger protein Sequoia interacts with the Notch pathway to control lineage progression.

Summary: Genome-editing approaches in zebrafish reveal that distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations.

Summary: ERK acts as a specific effector of Vegfa signaling to induce angiogenic genes during vascular sprouting in zebrafish.

Summary: The protein kinase IKKε is active at the growing tip of Drosophila bristles and prevents excess PKC activation during bristle actin bundle organization and morphogenesis.

Summary: During olfactory bulb development in mice, different axonal targeting outcomes are dependent on the timing of Nrp1/Sema3A signaling.

Summary: The conditional modulation of β-catenin activity in late hypertrophic chondrocytes locally regulates osteoclast differentiation and the transdifferentiation of chondrocytes into osteoblasts.

Summary: During chick limb development, FGF and TGFβ act independently of each other and downstream of mechanical forces to control tendon formation.

Summary: Ciona Tbx1, Ebf and Mrf homologs form an ancient conserved regulatory state for pharyngeal muscle specification, whereas their regulatory relationships are more evolutionarily variable.