Issues

Summary: This Meeting Review summarises the recent ISSCR/CiRA symposium on pluripotency in Kyoto, Japan, and the exciting progress that has been made in the ten years since iPSCs were first reported.

Summary: This Primer article provides an overview of phosphoinositide biogenesis, signaling and function during plant development and growth.

Summary: This Review considers the important, but often overlooked, role of the extracellular matrix in cell migration and tissue morphogenesis in amniotes.

Highlighted article: The analysis of zebrafish jawbone regeneration reveals important differences between how the skeleton is formed in the embryo and repaired in adults.

Summary: Chemical treatments combined with live imaging reveal that re-epithelialization of zebrafish wounds utilizes TGFβ/integrin-dependent active keratinocyte crawling as well as epidermal rearrangements.

Summary: EGFR signaling promotes the differentiation of stem cell-derived progenitors into mature gut cells during both normal homeostasis and regeneration of the planarian Schmidtea mediterranea.

Summary: A component of RNA polymerase III, which is responsible for the synthesis of small noncoding RNAs, plays a previously undescribed role in HSPC maintenance during zebrafish embryogenesis.

Highlighted article: During gonad development in Drosophila, Mdr49 acts in the Hh pathway to ensure the sufficient production of processed Hh that, in turn, signals to guide migrating PGCs.

Highlighted article: In radially migrating mouse cortical neurons, cadherin-mediated signaling to the cytoskeleton regulates the forward movement of the nucleus.

Summary: Regulation of the Nppa-Nppb cluster in normal and stressed hearts involves the concerted action of multiple enhancers and epigenetic changes distributed across a structurally rigid regulatory domain.

Summary: The translational repressors Nanos and Pumilio provide a crucial neuroprotective regulatory layer to ensure that Drosophila neurons behave appropriately in response to developmental cues.

Summary: In the mouse corneal epithelium, primary cilia are confined to basal cells and modulate Notch signaling and cell proliferation to maintain normal epithelial thickness.

Summary: Time-lapse imaging and biochemical studies suggest that Fat3 acts autonomously via Ena/VASP to orient the cytoskeleton in mouse amacrine cell precursors as they migrate and elaborate dendrites.

Summary: Syk kinases regulate the switch in growth cone behaviour, from attraction to repulsion, during spinal cord midline crossing in developing mouse embryos.

Summary: In Xenopus and chick embryos, the scaffolding activity of DACT1/2 is required for the local and transient inhibition of Wnt/β-catenin activity, a prerequisite for neural crest delamination.

Summary: In developing mouse embryos, Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.

Summary: 3D analyses of cardiac valve formation in zebrafish illustrate the complex cellular rearrangements that occur during this process in vivo.

Summary: BMP signaling regulates the expression of Dlx5 and Hmx3, transcription factors essential for vestibular development, through the canonical pSMAD pathway and a non-canonical pathway, respectively.

Summary: CARS microscopy provides a novel and non-invasive method of quantifying lipid content, type and spatial distribution in living mouse oocytes and pre-implantation embryos.