Issues
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Cover image
Cover Image
Cover: Three-dimensional rendering of a confocal image stack showing a single alveolar type 1 cell with expansive cellular extensions (green, GFP, genetically labelled with HopxCreER/+; RosamTmG/+) intertwined with the vasculature (blue, ICAM2) in the mouse lung. See Research article by Yang et al. on p. 54.
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IN THIS ISSUE
EDITORIAL
Future developments: your thoughts and our plans
Summary: In this Editorial, we discuss the results of a recent community survey on the current state and future directions of the journal.
REVIEW
When stem cells grow old: phenotypes and mechanisms of stem cell aging
Summary: This Review presents the latest advances in our understanding of stem cell aging in multiple tissues, and discusses their implications for lifespan, disease and potential therapies.
STEM CELLS AND REGENERATION
OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymal-epithelial transition
Highlighted article: The generation of a stable human intermediately reprogrammed stem cell line reveals differences in the mechanisms of reprogramming between mouse and human.
Selection and dynamics of embryonic stem cell integration into early mouse embryos
Summary: Following injection of mouse embryonic stem cells into host embryos, there is preferential and rapid elimination of unwanted differentiating cells by apoptosis.
Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts
Summary: Basal localisation of Miranda, essential for asymmetric neuroblast division in Drosophila, is regulated during mitosis via a two-step process involving PTPA/PP4 and aPKC.
Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling
Summary: Radial glia in the larval zebrafish hypothalamus exhibit stem cell-like properties. Their self-renewal is Wnt independent, although Wnt signalling does regulate their differentiation.
RESEARCH ARTICLES
The development and plasticity of alveolar type 1 cells
Highlighted article: Mouse lung alveolar type 1 cells form expansive thin cellular extensions via a non-proliferative two-step process, while retaining cellular plasticity.
The evolution of basal progenitors in the developing non-mammalian brain
Highlighted article: In the developing chick pallium, a basal progenitor population resembles mammalian cortical basal radial glia, suggesting a more ancient evolutionary origin for this cell type.
Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis
Highlighted article: A precise balance of matrix metalloproteinase activity at the Drosophila neuromuscular junction is required to regulate trans-synaptic Wingless signalling.
Neural crest cell-autonomous roles of fibronectin in cardiovascular development
Summary: Neural crest-derived fibronectin signals through integrin α5β1 to regulate Notch activity and differentiation of neural crest cells into vascular smooth muscle.
Pdx1 regulates pancreas tubulogenesis and E-cadherin expression
Summary: Mouse Pdx1 depletion in the pancreas leads to aberrant cell shape, impaired ductal tubulogenesis and loss of the epithelial multipotent progenitor cell population.
The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field
Summary: Early embryonic heart muscle differentiates in phases from two progenitor populations. AP-1 promotes the progenitor-to-cardiomyocyte transition specifically during the second phase.
Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target
Summary: In the zebrafish olfactory system, Sema3D-mediated repulsion and Netrin-mediated attraction act in parallel to direct a specific subset of sensory axons to their initial targets.
The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state
Summary: Mouse Pals1 mutants show defects in cerebellar organogenesis, with disrupted laminar organisation and impaired proliferation of cerebellar progenitors.
Reck enables cerebrovascular development by promoting canonical Wnt signaling
Summary: A zebrafish screen identifies reck as a key modulator of Wnt signaling required in the brain endothelium for intracerebral vascularisation and proper expression of barriergenesis markers.
Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation
Summary: During C. elegans embryonic elongation, microtubules nucleate at adjerens junctions and hemidesmosomes, and are important for the transport of junctional proteins.
TECHNIQUES AND RESOURCES
TimerQuant: a modelling approach to tandem fluorescent timer design and data interpretation for measuring protein turnover in embryos
Summary: A quantitative dual-colour reporter system can be used to measure protein turnover, signalling activity and gene expression kinetics in living zebrafish embryos.
CORRECTIONS
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
Development presents…
Development is excited to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are chaired each month by a different Development Editor, who invites talks from authors of exciting new papers and preprints. Visit Development presents... on the Node to see which topics are coming up and to catch up on recordings of past webinars.
Development’s Pathway to independence programme
We are delighted to announce a new call for our Pathway to Independence (PI) programme. This scheme is aimed at supporting postdocs planning to go on the job market in 2025, and will provide mentorship, training, networking and profile-raising opportunities. Apply by 31 Jan 2025.
Become a 2025 Node correspondent
The Node is looking for new correspondents to work together with the team to develop and produce content over the coming year. Apply by 20 January 2025.
