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IN THIS ISSUE

SPOTLIGHT

Summary: This Spotlight article compares the advantages and disadvantages of the different vertebrate model systems available to investigate neural crest development.

REVIEWS

Summary: This Review compares the mechanisms at play during inner ear hair cell development and regeneration, highlighting gaps in our knowledge and proposing future directions in research and therapeutics.

Summary: This Review discusses how satellite stem cell behaviour is regulated during regeneration and degeneration by a complex balance between extrinsic cues and intrinsic regulatory mechanisms.

STEM CELLS AND REGENERATION

Highlighted article: In the open environment of mouse seminiferous tubules, an undifferentiated stem cell pool is maintained by the differential expression of the retinoic acid receptor-γ in spermatogonia.

Summary: The proliferation, migration and survival of a subpopulation of olfactory bulb interneurons is regulated by COUP-TFI and COUP-TFII, two transcription factors expressed in the SVZ-RMS-OB system.

Summary: Mouse trophectoderm specification is regulated by AP-2γ/TFAP2C, which activates Cdx2 expression, controls actin dynamics and suppresses HIPPO signaling via multiple pathways, including the potentiation of cell polarity.

Summary: The proliferation of neural progenitor cells is regulated by Lin28a/b via their interaction with Imp1 and their regulation of Igf2-mTOR signaling.

Summary: During mammalian trunk formation, Wnt3a/β-catenin signaling maintains T+Sox2+ neuromesodermal progenitors located in the epithelial primitive streak and directs trunk progenitors towards a paraxial mesodermal fate.

RESEARCH ARTICLES

Highlighted article: Tubule morphogenesis in the Ciona intestinalis notochord is a non-linear process driven by the TGFβ-ROCK-mediated regulation of actomyosin contractility and Slc26-induced osmotic pressure.

Highlighted article: The ciliary localization of Gli2 is required for its release from Sufu inhibition and is therefore critical for Shh pathway activation.

Highlighted article: The size of cerebellar folia is determined by the cell number and cell dispersion of cerebellar granule cell precursor clones, which vary on different sides of the lineage boundary between lobules.

Summary: Chick limb morphogenesis occurs through issue elongation independently of cell proliferation, with three tissue growth modes correlated with SHH expression.

Summary: An RNAi screen reveals that SOAP-1 controls the apical localisation of AP-1, which recruits clathrin, necessary for E-cadherin polarisation and actin organisation during C. elegans embryonic elongation.

Summary: The formation of the arterial-venous shunt in zebrafish requires Sox7, which genetically interacts with hey2 and efnb2, activates the Notch signaling pathway and restricts flt4 expression.

Summary: The worm ubiquitin-like protein LGG-2/LC3 mediates the retrograde transport of autophagosomes to speed up their fusion with lysosomes during the clearance of sperm-inherited organelles after fertilization.

TECHNIQUES AND RESOURCES

Summary: Learning algorithms allow developmental dynamics to be reconstructed through the automatic registration and ordering of fixed images of developing tissues.

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From Disease Models & Mechanisms

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