Issues
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Cover image
Cover Image
Cover: During the last morphogenetic step of C. elegans embryonic development, apical actin (magenta) is organised as parallel bundles perpendicular to junctions (orange) and promotes elongation along the anteroposterior axis. The depletion of clathrin or of its adaptor AP-1 blocks elongation by disrupting E-cadherin apical trafficking and actin organisation. See Research article by Gillard et al. on p. 1684.
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IN THIS ISSUE
SPOTLIGHT
Animal models for studying neural crest development: is the mouse different?
Summary: This Spotlight article compares the advantages and disadvantages of the different vertebrate model systems available to investigate neural crest development.
REVIEWS
Sensory hair cell development and regeneration: similarities and differences
Summary: This Review compares the mechanisms at play during inner ear hair cell development and regeneration, highlighting gaps in our knowledge and proposing future directions in research and therapeutics.
Intrinsic and extrinsic mechanisms regulating satellite cell function
Summary: This Review discusses how satellite stem cell behaviour is regulated during regeneration and degeneration by a complex balance between extrinsic cues and intrinsic regulatory mechanisms.
STEM CELLS AND REGENERATION
Hierarchical differentiation competence in response to retinoic acid ensures stem cell maintenance during mouse spermatogenesis
Highlighted article: In the open environment of mouse seminiferous tubules, an undifferentiated stem cell pool is maintained by the differential expression of the retinoic acid receptor-γ in spermatogonia.
Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb
Summary: The proliferation, migration and survival of a subpopulation of olfactory bulb interneurons is regulated by COUP-TFI and COUP-TFII, two transcription factors expressed in the SVZ-RMS-OB system.
Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage
Summary: Mouse trophectoderm specification is regulated by AP-2γ/TFAP2C, which activates Cdx2 expression, controls actin dynamics and suppresses HIPPO signaling via multiple pathways, including the potentiation of cell polarity.
Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
Summary: The proliferation of neural progenitor cells is regulated by Lin28a/b via their interaction with Imp1 and their regulation of Igf2-mTOR signaling.
Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation
Summary: During mammalian trunk formation, Wnt3a/β-catenin signaling maintains T+Sox2+ neuromesodermal progenitors located in the epithelial primitive streak and directs trunk progenitors towards a paraxial mesodermal fate.
RESEARCH ARTICLES
Regulation by a TGFβ-ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis
Highlighted article: Tubule morphogenesis in the Ciona intestinalis notochord is a non-linear process driven by the TGFβ-ROCK-mediated regulation of actomyosin contractility and Slc26-induced osmotic pressure.
The loss of Hh responsiveness by a non-ciliary Gli2 variant
Highlighted article: The ciliary localization of Gli2 is required for its release from Sufu inhibition and is therefore critical for Shh pathway activation.
Clonal analysis reveals granule cell behaviors and compartmentalization that determine the folded morphology of the cerebellum
Highlighted article: The size of cerebellar folia is determined by the cell number and cell dispersion of cerebellar granule cell precursor clones, which vary on different sides of the lineage boundary between lobules.
Quantitative analysis of tissue deformation dynamics reveals three characteristic growth modes and globally aligned anisotropic tissue deformation during chick limb development
Summary: Chick limb morphogenesis occurs through issue elongation independently of cell proliferation, with three tissue growth modes correlated with SHH expression.
Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells
Summary: An RNAi screen reveals that SOAP-1 controls the apical localisation of AP-1, which recruits clathrin, necessary for E-cadherin polarisation and actin organisation during C. elegans embryonic elongation.
Sox7 controls arterial specification in conjunction with hey2 and efnb2 function
Summary: The formation of the arterial-venous shunt in zebrafish requires Sox7, which genetically interacts with hey2 and efnb2, activates the Notch signaling pathway and restricts flt4 expression.
Sperm-inherited organelle clearance in C. elegans relies on LC3-dependent autophagosome targeting to the pericentrosomal area
Summary: The worm ubiquitin-like protein LGG-2/LC3 mediates the retrograde transport of autophagosomes to speed up their fusion with lysosomes during the clearance of sperm-inherited organelles after fertilization.
TECHNIQUES AND RESOURCES
Temporal ordering and registration of images in studies of developmental dynamics
Summary: Learning algorithms allow developmental dynamics to be reconstructed through the automatic registration and ordering of fixed images of developing tissues.
ARTICLES OF INTEREST IN OTHER COB JOURNALS
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About us
Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register by 28 February 2025 to join us in March 2025 in Liverpool, UK.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
