Issues
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Cover image
Cover Image
Cover: Drosophila vav mutant pupal retina stained with anti-Disc large (septate junctions). The presence of extra cells of all types is due, on the one hand, to hyperactivation of the EGF receptor signalling pathway and, on the other hand, to excessive cell movements caused by the instability of adherens junctions. See Research article by Martín-Bermudo et al. on p. 1492.
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IN THIS ISSUE
EDITORIAL
Developing peer review
SUMMARY: In this Editorial, we discuss changes to Development's Reviewer Guidelines and Report Forms, which aim to make the peer-review process more efficient and helpful for authors.
DEVELOPMENT AT A GLANCE
Lysophosphatidic acid signalling in development
SUMMARY: This poster article summarises how lysophosphatidic acid is produced and metabolised during development, how it signals, and how it influences tissue and organ development.
REVIEW
Dynamic stem cell heterogeneity
SUMMARY: This Review highlights the role of dynamic heterogeneity and stochasticity in the regulation of adult stem cell populations.
STEM CELLS AND REGENERATION
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
HIGHLIGHTED ARTICLE: Peptides derived from the glucagon gene are necessary for α to β cell fate switching during pancreatic islet regeneration in zebrafish.
Brg1 modulates enhancer activation in mesoderm lineage commitment
SUMMARY: The chromatin remodeling factor Brg1 is essential for mesoderm induction and, by modulating active and repressive chromatin states, is involved in promoting the activation of dynamic enhancers.
RESEARCH REPORT
Slit cleavage is essential for producing an active, stable, non-diffusible short-range signal that guides muscle migration
HIGHLIGHTED ARTICLE: The muscle-repelling, secreted protein Slit is cleaved into a stable, membrane-tethered protein that acts as a short-range stop signal for migrating Drosophila muscle cells.
RESEARCH ARTICLES
Primary root protophloem differentiation requires balanced phosphatidylinositol-4,5-biphosphate levels and systemically affects root branching
HIGHLIGHTED ARTICLE: Protophloem differentiation in the Arabidopsisroot meristem requires locally balanced phosphoinositide levels, the disturbance of which impairs protophloem development and re-shapes root architecture.
The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage
SUMMARY: The transcription factor UNC-3, which regulates neuronal terminal differentiation, acts as a cell lineage-specific regulator of apoptosis in C. elegans embryogenesis.
Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung
SUMMARY: The histone methyltransferase Ezh2 inhibits basal cell differentiation in the mouse lung by depositing repressive marks on the promoter region of basal cell genes and by repressing Igf1 expression.
The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex
SUMMARY: Dachshund controls tissue growth in the Drosophila eye disc by limiting Yorkie/Homothorax-dependent bantam expression and by cooperating with Decapentaplegic signaling to repress homothorax expression.
Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation
SUMMARY: The AAA ATPase Vps4 is required for and promotes EGFR activity during Drosophila eye development, acting via an endocytosis-independent mechanism.
The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development
SUMMARY: Vav limits EGFR signalling to prevent excessive cell recruitment and regulates junction dynamics to ensure correct development of the fly eye, revealing novel functions for this proto-oncogene.
Genome-wide identification of phospho-regulators of Wnt signaling in Drosophila
SUMMARY: An RNAi screen identifies novel kinases and phosphatases that regulate the Wnt pathway under physiological conditions in the Drosophila wing disc.
Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation
SUMMARY: Wnt5a and Wnt11 control planar cell polarity signaling and epithelial-mesenchymal transition during elongation of the mouse anterior-posterior axis.
TECHNIQUES AND RESOURCES
Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
HIGHLIGHTED ARTICLE: Epicardial cells and their derivatives are generated from human pluripotent stem cells, an approach that has potential applications in the field of regenerative medicine.
SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish
SUMMARY: SNP variation in three common laboratory zebrafish strains is analyzed using whole-genome sequencing and is organized into a user-friendly and searchable online database.
CORRECTION
The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
