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IN THIS ISSUE

EDITORIAL

SUMMARY: In this Editorial, we discuss changes to Development's Reviewer Guidelines and Report Forms, which aim to make the peer-review process more efficient and helpful for authors.

DEVELOPMENT AT A GLANCE

SUMMARY: This poster article summarises how lysophosphatidic acid is produced and metabolised during development, how it signals, and how it influences tissue and organ development.

REVIEW

SUMMARY: This Review highlights the role of dynamic heterogeneity and stochasticity in the regulation of adult stem cell populations.

STEM CELLS AND REGENERATION

HIGHLIGHTED ARTICLE: Peptides derived from the glucagon gene are necessary for α to β cell fate switching during pancreatic islet regeneration in zebrafish.

SUMMARY: The chromatin remodeling factor Brg1 is essential for mesoderm induction and, by modulating active and repressive chromatin states, is involved in promoting the activation of dynamic enhancers.

RESEARCH REPORT

HIGHLIGHTED ARTICLE: The muscle-repelling, secreted protein Slit is cleaved into a stable, membrane-tethered protein that acts as a short-range stop signal for migrating Drosophila muscle cells.

RESEARCH ARTICLES

HIGHLIGHTED ARTICLE: Protophloem differentiation in the Arabidopsisroot meristem requires locally balanced phosphoinositide levels, the disturbance of which impairs protophloem development and re-shapes root architecture.

SUMMARY: The transcription factor UNC-3, which regulates neuronal terminal differentiation, acts as a cell lineage-specific regulator of apoptosis in C. elegans embryogenesis.

SUMMARY: The histone methyltransferase Ezh2 inhibits basal cell differentiation in the mouse lung by depositing repressive marks on the promoter region of basal cell genes and by repressing Igf1 expression.

SUMMARY: Dachshund controls tissue growth in the Drosophila eye disc by limiting Yorkie/Homothorax-dependent bantam expression and by cooperating with Decapentaplegic signaling to repress homothorax expression.

SUMMARY: The AAA ATPase Vps4 is required for and promotes EGFR activity during Drosophila eye development, acting via an endocytosis-independent mechanism.

SUMMARY: Vav limits EGFR signalling to prevent excessive cell recruitment and regulates junction dynamics to ensure correct development of the fly eye, revealing novel functions for this proto-oncogene.

SUMMARY: An RNAi screen identifies novel kinases and phosphatases that regulate the Wnt pathway under physiological conditions in the Drosophila wing disc.

SUMMARY: Wnt5a and Wnt11 control planar cell polarity signaling and epithelial-mesenchymal transition during elongation of the mouse anterior-posterior axis.

TECHNIQUES AND RESOURCES

HIGHLIGHTED ARTICLE: Epicardial cells and their derivatives are generated from human pluripotent stem cells, an approach that has potential applications in the field of regenerative medicine.

SUMMARY: SNP variation in three common laboratory zebrafish strains is analyzed using whole-genome sequencing and is organized into a user-friendly and searchable online database.

CORRECTION

ARTICLES OF INTEREST IN OTHER COB JOURNALS

From Journal of Cell Science

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