IN THIS ISSUE
DEVELOPMENT AT A GLANCE
STEM CELLS AND REGENERATION
HIGHLIGHTED ARTICLE: Peptides derived from the glucagon gene are necessary for α to β cell fate switching during pancreatic islet regeneration in zebrafish.
SUMMARY: The chromatin remodeling factor Brg1 is essential for mesoderm induction and, by modulating active and repressive chromatin states, is involved in promoting the activation of dynamic enhancers.
Slit cleavage is essential for producing an active, stable, non-diffusible short-range signal that guides muscle migration
HIGHLIGHTED ARTICLE: The muscle-repelling, secreted protein Slit is cleaved into a stable, membrane-tethered protein that acts as a short-range stop signal for migrating Drosophila muscle cells.
Primary root protophloem differentiation requires balanced phosphatidylinositol-4,5-biphosphate levels and systemically affects root branching
HIGHLIGHTED ARTICLE: Protophloem differentiation in the Arabidopsisroot meristem requires locally balanced phosphoinositide levels, the disturbance of which impairs protophloem development and re-shapes root architecture.
The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage
SUMMARY: The transcription factor UNC-3, which regulates neuronal terminal differentiation, acts as a cell lineage-specific regulator of apoptosis in C. elegans embryogenesis.
SUMMARY: The histone methyltransferase Ezh2 inhibits basal cell differentiation in the mouse lung by depositing repressive marks on the promoter region of basal cell genes and by repressing Igf1 expression.
The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex
SUMMARY: Dachshund controls tissue growth in the Drosophila eye disc by limiting Yorkie/Homothorax-dependent bantam expression and by cooperating with Decapentaplegic signaling to repress homothorax expression.
Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation
SUMMARY: The AAA ATPase Vps4 is required for and promotes EGFR activity during Drosophila eye development, acting via an endocytosis-independent mechanism.
The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development
SUMMARY: Vav limits EGFR signalling to prevent excessive cell recruitment and regulates junction dynamics to ensure correct development of the fly eye, revealing novel functions for this proto-oncogene.
SUMMARY: An RNAi screen identifies novel kinases and phosphatases that regulate the Wnt pathway under physiological conditions in the Drosophila wing disc.
TECHNIQUES AND RESOURCES
Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
HIGHLIGHTED ARTICLE: Epicardial cells and their derivatives are generated from human pluripotent stem cells, an approach that has potential applications in the field of regenerative medicine.
SUMMARY: SNP variation in three common laboratory zebrafish strains is analyzed using whole-genome sequencing and is organized into a user-friendly and searchable online database.