IN THIS ISSUE
STEM CELLS AND REGENERATION
Highlighted article: Using two complementary approaches, human pluripotent stem cells are differentiated into hypothalamic neurons that regulate sleep, feeding behavior and metabolism.
Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut
Summary: The generation of enteroendocrine cells from stem cells in the adult Drosophila midgut occurs via a distinct progenitor stage and involves the transcription factor Prospero.
Summary: Molecular mapping, lineage tracing and genetic analyses provide insight into the mechanisms governing enteroendocrine cell diversity in the adult Drosphila gastrointestinal tract.
Communication between distant epithelial cells by filopodia-like protrusions during embryonic development
Summary: Epithelial cells of chick embryo somites exhibit filopodia-like protrusions that serve as transport conduits connecting them to the overlying surface ectoderm.
Highlighted article: The vascularization of limb interdigital regions leads to an increase in tissue oxygenation that, in turn, triggers ROS production and cell death during mouse limb development.
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors
Highlighted article: In mice, obesity induces oocyte mitochondrial dysfunction that is transmitted to offspring but that can be reversed using interventions prior to conception.
Highlighted article: A new method for measuring tissue-scale force production is used to investigate the mechanical control of convergent extension in Xenopus embryos.
Highlighted article: Auxin-dependent cell specification during plant embryo development requires balanced and regulated auxin transport involving both influx and efflux machineries.
The cyclophilin A DIAGEOTROPICA gene affects auxin transport in both root and shoot to control lateral root formation
Summary: DIAGEOTROPICA modulates the localization of PIN proteins and is required for proper polar auxin transport, highlighting a new developmental role for this cyclophilin.
Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development
Summary: Components of the polycomb repressive complex 2 are expressed in neural crest cells and cooperate with Snail2 to modulate neural crest specification and migration.
Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development
Summary: The deletion of Pten reveals that Pten/Akt signaling coordinates BMP signaling and β-catenin to regulate the proliferation and differentiation of second heart field progenitors.
Summary: The characteristic eye loss seen in cavefish species occurs via different mechanisms, indicating that there are several ways to arrest the development and maintenance of an eye.
Summary: The transcription factor foxc1a is dispensable for trunk motor nerve guidance but is required to guide spinal nerves innervating the pectoral fins in zebrafish.
Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death
Summary: Jag1b differentially regulates FGF signaling, cell death and cell differentiation during the patterning of anterior and posterior cristae in the zebrafish inner ear.
Summary: UXT/ART27 is a novel repressor of Notch signaling that impairs the interaction between NICD and RBP-Jκ/CSL and is indispensable for zebrafish intersegmental vessel formation.
Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone
Summary: Cell populations expressing the transcription factors Scleraxis and Osterix are involved in the tensile force-induced remodeling of periodontal tissues in a position-specific manner.
Summary: α5 and αv integrins on neural-crest-derived vascular smooth muscle cells cooperate to control pharyngeal arch remodeling and are essential for heart and outflow tract septation.