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Summary: This Primer article reviews the molecular events regulating oligodendrocyte development in vivo and discusses approaches to generate oligodendrocytes in vitro.


Summary: This Review discusses similarities between the mechanisms patterning the Drosophila blastoderm and the vertebrate neural tube, suggesting a set of principles for morphogen-patterned tissues.


Highlighted article: Human ESCs derived from individual blastomeres of 8- and 12-cell human embryos have unique properties, provide insights into early human embryogenesis and enable human trophoblast stem cell derivation.

Summary: The bi-phasic modulation of microRNA-101a, which targets the oncogene fosab (cfos), regulates cardiomyocyte proliferation and scar tissue clearance in the injured adult zebrafish heart.

Summary: Dach2 and Hdac9 work in a collaborative fashion to inhibit the reinnervation of denervated mouse skeletal muscle by suppressing the denervation-dependent expression of Myog and Gdf5.


Summary: The analysis of chromatin state and H3K9me3 levels in mouse oocytes and early embryos provides insights into the dynamics of Xist repression and activation during early development and reprogramming.


Highlighted article: Hoxc8 misexpression in cervical somites and the overlying ectoderm of mice can convert skin into mammary ectoderm, with subsequent placode, bud and sprout development.

Highlighted article: Nek2 regulates both cilia biogenesis, by controlling centriole dynamics, and cilia resorption, via its interaction with Nup98, in the Xenopus left-right organizer.

Highlighted article: Cardiac contraction, which is sensed by primary cilia, activates Notch signaling in the endocardium to control ventricular trabeculation and maturation during heart development in zebrafish.

Summary: The SWI/SNF protein Brg1 controls cell cycle length, cell cycle exit and cell survival, and is required for cell differentiation and retinal lamination, in the developing mouse retina.

Summary: The kinase Src64 controls tyrosine phosphorylation and actin dynamics to mediate proper ring canal formation during incomplete cytokinesis, which is required for Drosophila germline cyst development in vivo.

Summary: A genetic screen uncovers a role for zinc finger protein 16-like as an important regulator of the oligodendrocyte lineage in zebrafish embryos.

Summary: The transcription factor ATAF2 is regulated by light and modulates brassinosteroid catabolism, suggesting that it acts to link light signaling and hormone metabolism during seedling development.

Summary: During lung development in mice, Fgf10 signaling plays an essential role in the formation of lipofibroblasts, which are required for the growth and survival of adult lung epithelial stem cells.

Highlighted article: The location of blood vessel sprouting and the rate of vessel elongation during development can be precisely predicted based on calculations of flow dynamics in avian embryos.


Highlighted article: A novel technique to concurrently image vessel morphology and blood flow in avian embryos allows precise quantification of the hemodynamic parameters that regulate vascular remodelling.

Summary: The optical clearing reagent ClearSee improves the multicolor imaging of fluorescent proteins and dyes and allows the structural analysis of gene expression patterns in multiple plant tissues.

Summary: CRISPR/Cas9 technology is used to effectively disrupt the genes encoding tyrosinase and FGF8/17/18 in the sea lamprey Petromyzon marinus.


From Journal of Cell Science
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