Issues
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Cover image
Cover Image
Cover: Whole-mount image (lambda stack of 19 images acquired at bandwidths spanning 460-648 nm) of an Arabidopsis pistil pollinated with LAT52pro::mTFP1, LAT52pro::sGFP, LAT52pro::Venus and LAT52pro::mApple pollen and cleared with ClearSee, a novel reagent that facilitates multicolour imaging of fluorescent proteins to reveal whole-plant as well as complex internal structure. See Research article by Kurihara et al. on p. 4168.
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IN THIS ISSUE
PRIMER
How to make an oligodendrocyte
Summary: This Primer article reviews the molecular events regulating oligodendrocyte development in vivo and discusses approaches to generate oligodendrocytes in vitro.
REVIEW
Morphogen rules: design principles of gradient-mediated embryo patterning
Summary: This Review discusses similarities between the mechanisms patterning the Drosophila blastoderm and the vertebrate neural tube, suggesting a set of principles for morphogen-patterned tissues.
STEM CELLS AND REGENERATION
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification
Highlighted article: Human ESCs derived from individual blastomeres of 8- and 12-cell human embryos have unique properties, provide insights into early human embryogenesis and enable human trophoblast stem cell derivation.
Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration
Summary: The bi-phasic modulation of microRNA-101a, which targets the oncogene fosab (cfos), regulates cardiomyocyte proliferation and scar tissue clearance in the injured adult zebrafish heart.
Dach2-Hdac9 signaling regulates reinnervation of muscle endplates
Summary: Dach2 and Hdac9 work in a collaborative fashion to inhibit the reinnervation of denervated mouse skeletal muscle by suppressing the denervation-dependent expression of Myog and Gdf5.
RESEARCH REPORT
Chromatin condensation of Xist genomic loci during oogenesis in mice
Summary: The analysis of chromatin state and H3K9me3 levels in mouse oocytes and early embryos provides insights into the dynamics of Xist repression and activation during early development and reprogramming.
RESEARCH ARTICLES
Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling
Highlighted article: Hoxc8 misexpression in cervical somites and the overlying ectoderm of mice can convert skin into mammary ectoderm, with subsequent placode, bud and sprout development.
The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry
Highlighted article: Nek2 regulates both cilia biogenesis, by controlling centriole dynamics, and cilia resorption, via its interaction with Nup98, in the Xenopus left-right organizer.
Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish
Highlighted article: Cardiac contraction, which is sensed by primary cilia, activates Notch signaling in the endocardium to control ventricular trabeculation and maturation during heart development in zebrafish.
Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma
Summary: The SWI/SNF protein Brg1 controls cell cycle length, cell cycle exit and cell survival, and is required for cell differentiation and retinal lamination, in the developing mouse retina.
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
Summary: The kinase Src64 controls tyrosine phosphorylation and actin dynamics to mediate proper ring canal formation during incomplete cytokinesis, which is required for Drosophila germline cyst development in vivo.
A zinc finger protein that regulates oligodendrocyte specification, migration and myelination in zebrafish
Summary: A genetic screen uncovers a role for zinc finger protein 16-like as an important regulator of the oligodendrocyte lineage in zebrafish embryos.
ATAF2 integrates Arabidopsis brassinosteroid inactivation and seedling photomorphogenesis
Summary: The transcription factor ATAF2 is regulated by light and modulates brassinosteroid catabolism, suggesting that it acts to link light signaling and hormone metabolism during seedling development.
Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development
Summary: During lung development in mice, Fgf10 signaling plays an essential role in the formation of lipofibroblasts, which are required for the growth and survival of adult lung epithelial stem cells.
Flow dynamics control the location of sprouting and direct elongation during developmental angiogenesis
Highlighted article: The location of blood vessel sprouting and the rate of vessel elongation during development can be precisely predicted based on calculations of flow dynamics in avian embryos.
TECHNIQUES AND RESOURCES
Simultaneous imaging of blood flow dynamics and vascular remodelling during development
Highlighted article: A novel technique to concurrently image vessel morphology and blood flow in avian embryos allows precise quantification of the hemodynamic parameters that regulate vascular remodelling.
ClearSee: a rapid optical clearing reagent for whole-plant fluorescence imaging
Summary: The optical clearing reagent ClearSee improves the multicolor imaging of fluorescent proteins and dyes and allows the structural analysis of gene expression patterns in multiple plant tissues.
CRISPR/Cas9-mediated mutagenesis in the sea lamprey Petromyzon marinus: a powerful tool for understanding ancestral gene functions in vertebrates
Summary: CRISPR/Cas9 technology is used to effectively disrupt the genes encoding tyrosinase and FGF8/17/18 in the sea lamprey Petromyzon marinus.
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
