Issues
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Cover image
Cover Image
Cover: Whole-mount confocal image of a mouse forelimb at E14.5. At this stage, tendon and muscle patterning is largely complete. Tendons and muscles are genetically labelled by ScxGFP (green) and Pax7Cre/Rosa-TdTomato (red), respectively. The distinct programmes that govern the early development of autopod and zeugopod tendons are integrated to achieve proper musculoskeletal organisation. See Research article by Huang et al. on p. 2431.
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IN THIS ISSUE
SPOTLIGHT
An interview with Brigid Hogan
Summary: We talked to Brigid Hogan, winner of the 2015 Society for Developmental Biology Lifetime Achievement Award, about her career, research and thoughts on the field.
DEVELOPMENT AT A GLANCE
The retromer complex in development and disease
Summary: This poster article summarises the role of the retromer complex in developmental processes, neuronal maintenance, and human neurodegenerative diseases.
PRIMER
LIN28: roles and regulation in development and beyond
Summary: This Primer article discusses how the RNA-binding protein LIN28 functions in development and disease, and how it regulates the transition between pluripotency and lineage commitment.
STEM CELLS AND REGENERATION
HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo
Highlighted article: Hypoxia inducible factor 1α is dispensable for embryonic myogenesis but, via the inhibition of canonical Wnt signaling, negatively regulates muscle regeneration in adult mice.
JNK signalling is necessary for a Wnt- and stem cell-dependent regeneration programme
Summary: The conserved JNK signalling pathway promotes Wnt signalling in stem cells to allow the regeneration of posterior structures in injured flatworms.
RESEARCH REPORT
A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development
Summary: MiR-127 is an essential regulator of the paternally expressed imprinted gene Rtl1 and acts via trans-homologue interactions to regulate Rtl1 dosage and placental growth.
RESEARCH ARTICLES
Musculoskeletal integration at the wrist underlies the modular development of limb tendons
Highlighted article: The analysis of tendon development in mice that have defective muscle or cartilage developmental programmes reveals a novel integrated model for limb tendon development.
Distinct developmental genetic mechanisms underlie convergently evolved tooth gain in sticklebacks
Highlighted article: Analyses of the natural variation in threespine stickleback populations reveal that largely distinct mechanisms underlie convergently evolved changes in tooth patterning.
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis
Highlighted article: Functional differences between Notch1 and Notch2 can be attributed to the strength and duration of signalling, rather than the composition of the receptors' intracellular domains.
C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types
Summary: Unlike in other organisms, SoxB and SoxC genes in C. elegans have no broad function in embryonic nervous system development; instead, SoxB genes control the terminal differentiation of restricted neuron types.
The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton
Summary: The gene mwh, which acts downstream in the Drosophila PCP pathway, directly acts on the cytoskeleton to ensure that each wing cell produces a single distally pointing hair.
MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors
Summary: MicroRNAs expressed in the mouse RPE are dispensable for RPE specification and survival but are required for maturation and differentiation of the RPE and adjacent photoreceptors.
Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm
Summary: In response to high levels of Wnt, tbx16 irreversibly flips a bistable switch that allows maintenance of mesodermal fate while repressing the bipotential neuromesodermal progenitor state in zebrafish embryos.
A dynamic intracellular distribution of Vangl2 accompanies cell polarization during zebrafish gastrulation
Summary: During gastrulation, the PCP protein Vangl2 first accumulates at cell membranes, in response to both intrinsic and extrinsic factors, and then becomes asymmetrically localized in highly polarized cells.
A common Shox2–Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
Summary: Antagonism between Shox2 and Nkx2-5 in the cardiac venous pole of mouse embryos regulates cell fate, morphogenesis and the distinction between pacemaker cells and working myocardium.
Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis
Summary: The transcription factor Atoh1 is sufficient to drive ectopic Merkel cell production in specific regions of mouse skin, with induction efficiency depending on age, hair cycle stage and Notch signalling.
CORRECTION
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
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Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
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