Issues
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Cover image
Cover Image
Cover: Expression profile of key transcription factors in the neural tube of a 3.5-day-old chicken embryo. This pattern is mainly regulated by Sonic Hedgehog signalling. The staining was performed using fluorescent immunocytochemistry against FOXA2 (magenta), NKX2.2 (cyan), OLIG2 (red) and PAX6 (green). The image was acquired using a Leica DM5500B compound microscope. See Research article by Stasiulewicz et al. on p. 2291.
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IN THIS ISSUE
SPOTLIGHT
An interview with Austin Smith
Summary: We talked to Austin Smith, director of the Cambridge Stem Cell Institute and editor of Development, about his career, his interests, and the state of the stem cell field.
DEVELOPMENT AT A GLANCE
LIF signaling in stem cells and development
Summary: This poster article provides an overview of the LIF-JAK-STAT signalling pathway and discusses how this pathway functions in stem cells and early development.
REVIEWS
The never-ending story: from pluripotency to plant developmental plasticity
Summary: This Review discusses how pluripotency is established in plant stem cell systems, how it is maintained during development and growth, and how it is re-initiated during regeneration.
Computational modelling of embryonic stem-cell fate control
Summary: This Review discusses the principles, applications and limitations of different computational strategies used to study the mechanisms underlying pluripotency regulation in embryonic stem cells.
STEM CELLS AND REGENERATION
Bag of Marbles controls the size and organization of the Drosophila hematopoietic niche through interactions with the Insulin-like growth factor pathway and Retinoblastoma-family protein
Summary: Drosophila hematopoetic niche cells express Bag of Marbles (Bam), which interacts with insulin receptor signalling to control expression of Retinoblastoma factor, and hence cell number and niche morphology.
Traffic jam functions in a branched pathway from Notch activation to niche cell fate
Highlighted article: The Maf factor Traffic jam functions to restrict niche cell fate in the Drosophila male gonad and is downregulated downstream of Notch during hub cell specification.
Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression
Summary: The transcription factor Hbp1 regulates neural development in mouse: upon Hbp1 depletion, progenitor cell cycle length shortens due to derepression of cyclin D1, and neuronal differentiation is also impaired.
RESEARCH ARTICLES
A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo
Highlighted article: Shh signalling controls dorso-ventral cell fate in the neural tube. Notch regulates ciliary architecture and localisation of key Shh pathway components, thus sensitising cells to Shh.
Myocardium and BMP signaling are required for endocardial differentiation
Highlighted article: Interactions between the myocardium and endocardium are important for heart development, with myocardium-derived BMP signals playing a key role in specifying endocardial fate.
A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo
Highlighted article: In the early syncitial Drosophila embryo, membrane furrows form and regress as nuclei divide. This depends on RalA and is important for the maintenance of genome integrity.
FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis
Highlighted article: Body axis elongation is regulated by posterior FGF8 signals . In chicken, nephric duct extension also requires this FGF8 signal, while low FGF8 anteriorly triggers duct lumen formation.
A transport and retention mechanism for the sustained distal localization of Spn-F–IKKε during Drosophila bristle elongation
Summary: In the Drosophila bristle, the microtubule binding protein Jvl, the adaptor Spn-F and cytoplasmic dynein are required for localised transport and retention of polarised signalling factors.
BMP signalling controls the construction of vertebrate mucociliary epithelia
Summary: The BMP pathway controls both morphognenesis of and cell type specification in mucociliary epithelia: the Xenopus embryonic epidermis and regenerating human airways.
The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling
Summary: Mice lacking endothelial CCN1 show severe defects in retinal vessel network formation and barrier integrity, associated with endothelial cell hyperproliferation.
CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis
Summary: In early mouse embryos, the chromatin remodeller CHD1 promotes the expression of Hmgpi at zygotic gene activation, which in turn regulates key factors involved in pluripotency and differentiation.
CORRECTIONS
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
