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IN THIS ISSUE

SPOTLIGHT

SUMMARY: We recently interviewed Juergen Knoblich, a Senior Scientist and Deputy Scientific Director of the IMB in Vienna, to ask him about his research and his thoughts on funding.

MEETING REVIEW

SUMMARY: A recent Keystone Symposium highlighted both the new discoveries and the substantial progress that has been made in the hematopoiesis field.

REVIEW

SUMMARY: This Review summarises evidence from ichthyologists, paleontologists and developmental biologists and discusses the mechanisms that regulate and diversify vertebral patterning.

STEM CELLS AND REGENERATION

SUMMARY: Germ granules in C. elegans are required for fertility and the maintenance of germ cell identity, but also function to repress sperm-specific expression in during oogenesis.

SUMMARY: The Drosophila testis responds to protein starvation by eliminating transit-amplifying spermatogonia while maintaining actively proliferating germline stem cells, revealing a tissue-wide response that maintains homeostasis.

SUMMARY: The study of zebrafish embryos deficient for Gpc4 reveals that it is essential for efficient cardiomyocyte differentiation, providing insights into how mutations in glypicans can cause congenital heart defects.

RESEARCH REPORT

SUMMARY: The cytoskeletal adaptor protein Girdin physically and functionally interacts with cadherin-catenin complex components to regulate adherens junctions and hence cell adhesion during Drosophila embryogenesis.

RESEARCH ARTICLES

HIGHLIGHTED ARTICLE: Real-time imaging of clock gene oscillations in zebrafish embryos reveals that the segmentation clock shifts from one- to two-segment periodicity, suggesting an updated model for somite formation.

HIGHLIGHTED ARTICLE: Long tubular cells in the trachea of Drosophila larvae divide through a combination of junctional rearrangement and asymmetrical cytokinesis.

HIGHLIGHTED ARTICLE: The chromatin remodelling protein ATRX is transmitted to the early zygote through the maternal germ line and is required to silence major satellite transcripts and control chromosome stability.

HIGHLIGHTED ARTICLE: Overlapping but distinct sets of FGF receptors mediate FGF22- and FGF7-dependent excitatory and inhibitory presynaptic differentiation in the mammalian hippocampus, in part through FRS2/PI3K signaling.

HIGHLIGHTED ARTICLE: The patella originates from a pool of Sox9- and Scx-positive progenitors that is separated from the femur during the process of joint formation, which in turn is regulated by mechanical load.

SUMMARY: The paracrine activity of Engrailed, together with its PBX-interacting hexapeptide motif, is involved in boundary formation during brain development in zebrafish.

SUMMARY: BMP signals from the lens are crucial to maintain eye-field character, inhibit dorsal telencephalic cell identity, and specificy neural retina cells in chick embryos.

SUMMARY: Mathematical modeling and simulations suggest that the local diffusion of homeoproteins during neuronal differentiation is enough to create smooth and reliable boundaries between cortical areas.

SUMMARY: The trafficking and localization of Crumbs, a key regulator of epithelial polarity, is dynamically regulated by the ERM protein Moesin in competition with aPKC during Drosophila egg chamber morphogenesis.

TECHNIQUES AND RESOURCES

SUMMARY: Chromobodies - small, intracellular fluorescent antibodies - are used to trace endogenous antigens, without the need for direct protein tagging, in zebrafish embryos.

SUMMARY: The adeno-associated virus variant r3.45 is used to efficiently and selectively transduce adult mouse, rat, and human neural stem cells both in vitro and in vivo.

SUMMARY: The developmental anatomy of the lower urinary and reproductive systems of developing and postnatal mice is described, providing a revised ontology to aid the understanding of human urogenital tract abnormalities.

ARTICLES OF INTEREST IN OTHER COB JOURNALS

From Journal of Cell Science

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