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Volume 134, Issue 3

February 2007

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Cover image

Cover Image

Cover: In situ hybridization of the vegetal region of an 8-cell stage Xenopus laevis embryo using a probe for Wnt11 mRNA, showing that Wnt11 mRNA is localized in dorsal vegetal blastomeres. Depletion of Wnt11, or of its receptor LRP6, leads to loss of axis formation. (In situ by Stephanie Lang.) See research article by Kofron et al. on p. 503
Table of contents

ISSN 0950-1991

EISSN 1477-9129

In this issue

REVIEW
RESEARCH REPORT
RESEARCH ARTICLE
IN THIS ISSUE

REVIEW

Pancreas and beta-cell development: from the actual to the possible

L. Charles Murtaugh

Abstract

View articletitled, Pancreas and beta-cell development: from the actual to the possible

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Getting axons onto the right path: the role of transcription factors in axon guidance

Samantha J. Butler,Guy Tear

Abstract

View articletitled, Getting axons onto the right path: the role of transcription factors in axon guidance

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RESEARCH REPORT

Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice

Mayuko Ishii,Tsuyoshi Tachiwana,Anshin Hoshino,Naoki Tsunekawa,Ryuji Hiramatsu,Shogo Matoba,Masami Kanai-Azuma,Hayato Kawakami,Masamichi Kurohmaru,Yoshiakira Kanai

Abstract

View articletitled, Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice

Supplementary information

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RESEARCH ARTICLE

Regulation of redox metabolism in the mouse oocyte and embryo

Rémi Dumollard,Zoe Ward,John Carroll,Michael R. Duchen

Abstract

View articletitled, Regulation of redox metabolism in the mouse oocyte and embryo

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Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis

Shusaku Shibutani,Lisa M. Swanhart,Robert J. Duronio

Abstract

View articletitled, Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis

Supplementary information

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Distinct Wnt signaling pathways have opposing roles in appendage regeneration

Cristi L. Stoick-Cooper,Gilbert Weidinger,Kimberly J. Riehle,Charlotte Hubbert,Michael B. Major,Nelson Fausto,Randall T. Moon

Abstract

View articletitled, Distinct Wnt signaling pathways have opposing roles in appendage regeneration

Supplementary information

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Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination

Irit Shoval,Andreas Ludwig,Chaya Kalcheim

Abstract

View articletitled, Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination

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Wnt11/β-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin

Matt Kofron,Bilge Birsoy,Douglas Houston,Qinghua Tao,Christopher Wylie,Janet Heasman

Abstract

View articletitled, Wnt11/β-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin

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Nkx2.2-repressor activity is sufficient to specify α-cells and a small number of β-cells in the pancreatic islet

Michelle J. Doyle,Zoe L. Loomis,Lori Sussel

Abstract

View articletitled, Nkx2.2-repressor activity is sufficient to specify α-cells and a small number of β-cells in the pancreatic islet

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Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling

Ryuma Haraguchi,Jun Motoyama,Hiroshi Sasaki,Yoshihiko Satoh,Shinichi Miyagawa,Naomi Nakagata,Anne Moon,Gen Yamada

Abstract

View articletitled, Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling

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Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

Marc Vooijs,Chin-Tong Ong,Brandon Hadland,Stacey Huppert,Zhenyi Liu,Jeroen Korving,Maaike van den Born,Thaddeus Stappenbeck,Yumei Wu,Hans Clevers,Raphael Kopan

Abstract

View articletitled, Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

Supplementary information

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Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Martine Manuel,Petrina A. Georgala,Catherine B. Carr,Simon Chanas,Dirk A. Kleinjan,Ben Martynoga,John O. Mason,Michael Molinek,Jeni Pinson,Thomas Pratt,Jane C. Quinn,T. Ian Simpson,David A. Tyas,Veronica van Heyningen,John D. West,David J. Price

Abstract

View articletitled, Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Supplementary information

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The mouse seminal vesicle shape mutation is allelic with Fgfr2

Sheri L. Kuslak,Joshua L. Thielen,Paul C. Marker

Abstract

View articletitled, The mouse seminal vesicle shape mutation is allelic with Fgfr2

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Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila

Donald T. Fox,Mark Peifer

Abstract

View articletitled, Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila

Supplementary information

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Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes

Yuki Takada,Kyo-ichi Isono,Jun Shinga,James M. A. Turner,Hiroshi Kitamura,Osamu Ohara,Gen Watanabe,Prim B. Singh,Takehiko Kamijo,Thomas Jenuwein,Paul S. Burgoyne,Haruhiko Koseki

Abstract

View articletitled, Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes

Supplementary information

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The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression

Graham B. Thomas,Donald J. van Meyel

Abstract

View articletitled, The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression

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Hexamerin-based regulation of juvenile hormone-dependent gene expression underlies phenotypic plasticity in a social insect

Xuguo Zhou,Matthew R. Tarver,Michael E. Scharf

Abstract

View articletitled, Hexamerin-based regulation of juvenile hormone-dependent gene expression underlies phenotypic plasticity in a social insect

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Specification of epibranchial placodes in zebrafish

Alexei Nechiporuk,Tor Linbo,Kenneth D. Poss,David W. Raible

Abstract

View articletitled, Specification of epibranchial placodes in zebrafish

Supplementary information

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Neurogenic role of Gcm transcription factors is conserved in chicken spinal cord

Laurent Soustelle,Françoise Trousse,Cécile Jacques,Julian Ceron,Philippe Cochard,Cathy Soula,Angela Giangrande

Abstract

View articletitled, Neurogenic role of Gcm transcription factors is conserved in chicken spinal cord

Supplementary information

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IN THIS ISSUE

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Accepted manuscripts alert

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Latest published articles alert

Accepted manuscripts

Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms

Clarisse Perron, Pascal Carme, Arnau Llobet Rosell, Eva Minnaert, Salomé Ruiz Demoulin, Héloïse Szczkowski, Lukas Jakob Neukomm, Jean-Maurice Dura, Ana Boulanger

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs

Shou Soeda, Masaaki Oyama, Hiroko Kozuka-Hata, Tadashi Yamamoto

The Tbx20-TLE interaction is essential for the maintenance of the second heart field

Whitney Edwards, Olivia K. Bussey, Frank L. Conlon

A CDC-42-regulated actin network contributes to nuclear migration through constricted spaces in C. elegans

Jamie Ho, Leslie A. Guerrero, Diana Libuda, G. W. Gant Luxton, Daniel A. Starr

The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border

Ankita Thawani, Helen R. Maunsell, Hongyuan Zhang, Harinarayana Ankamreddy, Andrew K. Groves

More accepted manuscripts

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Development presents... live stream of our Journal Meeting

Development presents advert outlining details of the live stream.

Watch a session from Development’s Journal Meeting, Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology which was live on the Node Monday 18 September.

Navigating a research career with a disability

Images showing resources which can aid disabled researchers in the lab. Red Dycem tape enhances the grip of objects, such as this 500 ml bottle, making it easier to open bottles and lift heavier objects, and provides stability for fine motor tasks. The height-adjustable black armrest provides support at the lab bench. It can be used to provide stability during fine motor tasks (such as dissections) or decrease fatigue from repetitive tasks, such as pipetting.

Our two recent Perspectives articles explore the lived experiences of disabled scientists in our community. Kelsey L. Anbuhl and colleagues describe the lived experiences of five biologists who share the challenges and successes of undertaking a scientific career with a disability. Whereas Jack Darius Morgan reviews the literature exploring disabled scientists’ experiences in academia.

Focus on regeneration

Transverse sections of ventricles isolated from fish in the experiment illustrated in B, fluorescently stained for pS6 and F-actin. The areas that are shown at higher magnification are outlined. n≥5.

Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. Here, Development has collated a series of articles showcasing some of the most recent advances in regenerative biology.

Keeping up with the Node: Lab meetings

Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. August featured the Nichols lab at the University of Edinburgh, read their 'Lab meeting' article here.

Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.

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