Issues

Summary: This Review article contains an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.

Highlighted Article: Integration of multiple modes of transcriptomic and anatomical data expands the first-trimester human heart atlas with new dimensions, from fine-grained molecular profiles of developing cardiac cell types to their temporal and spatial relationships.

Summary: Prep, a protein regulated by Tet2-mediated DNA demethylation and that activates important growth pathways, is crucial for liver regeneration in zebrafish and offers potential targets for treating chronic liver injury.

Highlighted Article: In contrast to earlier reports, this paper identifies functional motor neurons in the Ciona larval tail, pointing to homology of the Ciona caudal nerve cord with the vertebrate spinal cord.

Summary: Arabidopsis bHLH60 transcription factor counteracts the AS1-AS2 complex to regulate BP1 expression by binding directly to the E-box element in the BP1 promoter to modulate leaf development.

Summary: Initiation and termination of female germline stem cell differentiation requires the appearance and clearance of the same regulator, Bag of marbles.

Highlighted Article: Guided by cilia directionality, the somata of principal neurons in inside-out laminated regions undergo a slow but substantial reverse movement for postnatal cell positioning that refines cortical layering.

Summary: The wing scales of butterflies and moths are derived from sensory organ precursors and are homologues of mechanosensory bristles.

Summary: Pou4f2 overexpression in late retinal progenitors reopens the competence window for the generation of retinal ganglion cells (RGCs), generating RGC-like cells that project axons to specific brain targets.

Summary: A combination of functional genetics, NanoDam and quantitative imaging reveals a role for an atypical E2F, EFL-3/E2F7, in epidermal stem cell fate determination in C. elegans.