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2020 collection: CRISPR/Cas technology

On October 7 2020, The Nobel Prize for Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for 'the development of a method for genome editing'. Although genome editing technologies such as zinc-finger nucleases and TALENS existed before the work of Charpentier and Doudna, CRISPR/Cas technology has revolutionised the developmental biology field, dramatically cutting the time and effort involved in making targeted mutations in model organisms and, importantly, giving us tools for genome editing that can be used in a wide range of non-traditional model systems. Not only that, but the CRISPR system has been adapted in a multitude of innovative ways to allow us to conduct genetic screens, control gene expression, perform complex lineage tracing experiments and more.

In this subject collection, we highlight just a few of the CRISPR papers published in Development since Charpentier and Doudna's groundbreaking work - from early applications of CRISPR to the Drosophila system through to recent uses of CRISPR for single cell lineage tracing. Of course, CRISPR has not been without its controversies, perhaps most notably in 2018 when the first CRISPR-edited human babies were announced. In this collection, we also include two Spotlight articles that discuss the technical and ethical challenges with using CRISPR in human, and a third that highlights how our understanding of developmental biology - combined with genome engineering - might influence agricultural science.

Other subject collections

Special Collection Image
TECHNIQUES AND RESOURCES
James Cotterell; Marta Vila-Cejudo; Laura Batlle-Morera; James Sharpe
Doi: 10.1242/dev.184481
SPOTLIGHT
Robin Lovell-Badge
Doi: 10.1242/dev.175778
SPOTLIGHT
Scott A. Boden; Lars Ă˜stergaard
Doi: 10.1242/dev.172965
TECHNIQUES AND RESOURCES
He Zhang; Hong Pan; Changyang Zhou; Yu Wei; Wenqin Ying; Shuting Li; Guangqin Wang; Chao Li; Yifei Ren; Gen Li; Xu Ding; Yidi Sun; Geng-Lin Li; Lei Song; Yixue Li; Hui Yang; Zhiyong Liu
Doi: 10.1242/dev.168906
TECHNIQUES AND RESOURCES
Ruth M. Williams; Upeka Senanayake; Mara Artibani; Gunes Taylor; Daniel Wells; Ahmed Ashour Ahmed; Tatjana Sauka-Spengler
Doi: 10.1242/dev.160333
SPOTLIGHT
Alvaro Plaza Reyes; Fredrik Lanner
Doi: 10.1242/dev.139683
TECHNIQUES AND RESOURCES
Yuji Tsunekawa; Raymond Kunikane Terhune; Ikumi Fujita; Atsunori Shitamukai; Taeko Suetsugu; Fumio Matsuzaki
Doi: 10.1242/dev.136325
TECHNIQUES AND RESOURCES
Alexa Burger; Helen Lindsay; Anastasia Felker; Christopher Hess; Carolin Anders; Elena Chiavacci; Jonas Zaugg; Lukas M. Weber; Raul Catena; Martin Jinek; Mark D. Robinson; Christian Mosimann
Doi: 10.1242/dev.134809
TECHNIQUES AND RESOURCES
Anna F. Gilles; Johannes B. Schinko; Michalis Averof
Doi: 10.1242/dev.125054
REVIEW
Ying Peng; Karl J. Clark; Jarryd M. Campbell; Magdalena R. Panetta; Yi Guo; Stephen C. Ekker
Doi: 10.1242/dev.102186
TECHNIQUES AND RESOURCES
Nicola A. Kearns; Ryan M. J. Genga; Metewo S. Enuameh; Manuel Garber; Scot A. Wolfe; René Maehr
Doi: 10.1242/dev.103341
TECHNIQUES AND RESOURCES
Luis Alberto Baena-Lopez; Cyrille Alexandre; Alice Mitchell; Laurynas Pasakarnis; Jean-Paul Vincent
Doi: 10.1242/dev.100933
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