The mouse t-complex is a region of chromosome 17, found in wild mouse populations, which is grossly rearranged when compared to those of normal laboratory strains. So far, two large, independent inversions have been demonstrated. The distal inversion includes the entire Major Histocompatibility Complex (MHC) (Artzt, Shin & Bennett, 1982; Shin et al. 1983; Pla & Condamine, 1984) and the recently discovered proximal inversion (Herrmann et al. 1986) also contains many genes, including the t-complex polypeptide-1 gene (Tcp-1) discussed in this article. Using in situ hybridization, the MHC (Lader et al. 1985) and Tcp-1 (Lyon et al. 1986) genes have been positioned on chromosome 17 and the t-complex would appear to occupy Giemsa bands 17B and 17A3, representing roughly 15 % of the chromosome. Presumably, in addition to those already mapped, many hundreds of genes are located in this region.
Pathway to Independence programme
We’re excited to announce our new Pathway to Independence programme, aimed at supporting postdocs as they go on the job market. Find out more about the scheme in our Editorial.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Transitions in development: Daniel Grimes
Daniel Grimes’s lab studies the consequences of ciliary mutations, including left-right patterning defects and scoliosis. We interviewed Daniel to find out more about his career path, his experience of becoming a group leader and the influence of Jurassic Park.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
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