Monoclonal antibodies were raised against differentiated cells, and blastemal cells from regenerating limbs of adult newts (Notophthalmus viridescens) and screened for specific staining by immunocytochemistry. In addition to antibodies that identify muscle, Schwann cells and cartilage, two reagents were specific for subpopulations of blastemal cells. One of these latter antibodies, termed 22/18, has provided new evidence about the origin of blastemal cells from Schwann cells and rnyofibres, and also identifies blastemal cells whose division is persistently dependent on the nerve supply.
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Journal Article| 01 October 1985
Monoclonal antibodies to the cells of a regenerating limb
Chris R. Kintner,
Chris R. Kintner
Division of Biology, California Institute of Technology, Pasadena, CA 91125, U.S.A.
Jeremy P. Brockes
MRC Cell Biophysics Unit, Kings College London, 26–29 Drury Lane, London, WC2B 5RL, U.K.
Accepted: 26 Apr 1985
Online Issn: 1477-9129
Print Issn: 0950-1991
Copyright © 1985 by Company of Biologists
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Chris R. Kintner, Jeremy P. Brockes; Monoclonal antibodies to the cells of a regenerating limb. Development 1 October 1985; 89 (1): 37–55. doi: https://doi.org/10.1242/dev.89.1.37
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