The effects of wounding the lower region of rat vibrissa follicles with a sharp tungsten needle were examined histologically, both shortly after injury and up to one year postoperatively. Following cell damage in the dermal papilla component hair growth ceased, and resumption of fibre production was always preceded by dermal papilla reformation. This papilla healing and regeneration was not associated with the production of scar tissue. In follicles undergoing no cell displacement during wounding (an effect associated with the growth of longer than normal hairs) dermal papillae were reformed from the residual papilla cell population, with recruitment of cells from surrounding mesenchyme. Follicles plucked just prior to wounding revealed little or no original epidermal matrix three days later, confirming that dermal components were primarily affected. Papilla cell counts performed on follicles which had consistently produced longer hairs gave no indication of increased papilla cell numbers. Follicles which underwent displacement of cellular material and displayed distortion of normal follicle morphology shortly after wounding (effects associated with the production of shorter than normal hairs) also revealed abnormalities at long-term biopsy. Moreover these follicles often had a history of altered fibre characteristics from one postoperative generation to the next. It is concluded that gross morphological disruption of the normal cellular relationships in the lower follicle results in a series of reorganizational difficulties with each recurring phase of the hair cycle.
Histological studies of the effects of wounding vibrissa follicles in the hooded rat
Colin A. B. Jahoda, Roy F. Oliver; Histological studies of the effects of wounding vibrissa follicles in the hooded rat. Development 1 October 1984; 83 (1): 95–108. doi: https://doi.org/10.1242/dev.83.1.95
Download citation file:
Advertisement
Cited by
Development Journal Meeting 2022: From Stem Cells to Human Development
-JournalMeeting.png?versionId=3773)
Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
(update)-ImmuneSI.png?versionId=3773)
Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells. You can watch recordings from our Development presents... webinar celebrating the special issue here.
Propose a new Workshop
-GSWorkshop.png?versionId=3773)
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
(update)-InPreprints.png?versionId=3773)
As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
-FocalPlaneNetworkLaunch.png?versionId=3773)
Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.