The fate of mouse blastocyst tissues was examined following reconstitution of blastocystsfrom isolated inner cell mass (ICM) and trophectoderm differing for electrophoretic variantsat the glucose phosphate isomerase (GPI-1) locus. A modified microsurgical method was usedand a more sensitive enzyme assay allowed finer dissection of developing chimaeric con-ceptuses. In seven of nine cases, the extraembryonic ectoderm or the later ectoderm of thechorion was entirely of the blastocyst trophectoderm enzyme type, providing the first ditectevidence that this tissue can be wholly derived from the trophectoderm. The two exceptionscould represent contamination of the ICM with trophectoderm or might indicate somedevelopmental lability of ICM cells. In addition, the results confirm the cell lineages of othertissues of the 7·5- to 9·5-day pc embryo and, for the first time, directly demonstrate the ICMorigin of the parietal endoderm.
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
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Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
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Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.
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