This article includes recent preLights posts that discuss preprints in the field of developmental and stem cell biology.
Featured preLight
Germplasm stability in zebrafish requires maternal Tdrd6a and Tdrd6c by Alessandro Consorte et al.
Localisation of germplasm visualised using BucEGFP, in control, 6a mmut, 6c mmut, and 6a6c mmut embryos at 1hpf, 2hpf, and 3hpf. Figure 4A from Consorte et al. (BioRxiv) published under a CC-BY-NC-ND 4.0 International license.
preLighter(s)
Justin Gutkowski IRTA Postbaccalaureate Fellow at the NICHD, Bethesda, USA
Why it was selected
I've highlighted this preprint because I am interested in germ cell specification and development. This preprint details an aspect of these processes that I was unaware of: the loss of germplasm in an embryo due to the lack of maintenance signals, even after it is specified. I also found it interesting that the genetic signals involved in this process exhibit redundancy, which is typically characteristic of critical processes in vertebrate development.
Other relevant preLight post
Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo by Daniel M. Snell et al.
WHO – The X and Y. WHEN – Since the beginning. HOW - From a distance.
Selected by Mansi. Read the preLight.
Chromosomal instability in human trophoblast stem cells and placentas by Danyang Wang et al.
The trophoblast: where instability is intrinsic.
Selected by Carly Guiltinan. Read the preLight.
Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis by Joshua Hawley et al.
Notching it up a bit: distant cells can receive Notch signalling through cellular protrusions in the developing spinal cord.
Selected by Ankita Walvekar. Read the preLight.
Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation by Marianne Basso et al.
Actin up under pressure: cell differentiation and nuclear deformation.
Selected by Ryan Harrison. Read the preLight.
Long range mutual activation establishes Rho and Rac polarity during cell migration by Henry De Belly et al.
Rac and Rho team up! Long-distance mechanochemical coordination for migration.
Selected by Vibha Singh. Read the preLight.
Golgi compaction facilitates microtubule nucleation to drive adult vertebrate peripheral neuron regeneration by Alice E Mortimer et al.
Rebuilding nerves: Golgi compaction paves the way to neuron repair!
Selected by Vibha Singh. Read the preLight.
HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos by Estefania Sanchez-Vasquez et al.
Hypoxia regulates embryonic fitness in mosaic aneuploid embryos.
Selected by Anchel De Jaime Soguero. Read the preLight.
Axis reset is rate limiting for onset of whole-body regenerative abilities during planarian development by Clare L.T. Booth et al.
Heads or Tails? Clare Booth and team characterise the developmental onset of regeneration in the flatworm Schmidtea polychroa.
Selected by Isabella Cisneros. Read the preLight.
