Species-specific developmental timing is associated with global differences in protein stability in mouse and humanby Rayon et al.

Do you want (your embryonic development) to go slower? Make your proteins live longer!

Selected by Irepan Salvador-Martinez. Read the preLight here

The transcriptional legacy of developmental stochasticityby Ballouz et al.

Developmental stochasticity gives rise to transcriptional signatures that mark identity in armadillo quadruplets.

Selected by Sergio Menchero. Read the preLight here

Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian developmentby Saiz et al.

FGF4 signalling in the blastocyst: A simple system for an important binary cell fate decision.

Selected by Pierre Osteil and Irepan Salvador-Martinez. Read the preLight here

Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafishby El-Maï et al.

Pushed into senescence: El-Maï and colleagues elucidate an age-related apoptosis to senescence switch in telomerase deficient zebrafish.

Selected by Lorenzo Lafranchi. Read the preLight here

Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Divisionby Ko et al.

The ins and outs of apical constriction: spatial patterns of mitosis within a contractile tissue regulate tissue invagination.

Selected by Grace Lim. Read the preLight here

Behavioral signatures of a developing neural codeby Avitan et al.

Young fish go hunting! Avitan et al. investigate the neural correlates of developing behavioral signatures.

Selected by Amrutha Swaminathan. Read the preLight here

Distinct activities of Scrib module proteins organize epithelial polarityby Khoury & Bilder


Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKCby Ventura et al.

Getting the upper hand: recent preprints describe how Lgl can be resistant to the action of aPKC with the help of ‘friends’ in the basolateral domain, whilst allowing aPKC to remain the dominant force apically.

Selected by Helen Zenner. Read the preLight here

Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early developmentby Pimpale et al.

Pimpale et al. show how chirality of cortical flows influences cell positioning throughout development.

Selected by Lars Hubatsch. Read the preLight here

Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophagesby Bain et al.

Tissue Residency and Sexually Dimorphic Function in Peritoneal Macrophages.

Selected by Connor Rosen. Read the preLight here

Architectural RNA is required for heterochromatin organizationby Thakur et al.

Cut the anchor: CUT&RUN.RNase identifies scaffolding of heterochromatic domains by RNA.

Selected by Ramona Jühlen. Read the preLight here

Enhancers predominantly regulate gene expression in vivo via transcription initiationby Larke et al.

Initiation appears to be more important than pausing in transcriptional regulation.

Selected by Clarice Hong. Read the preLight here

Direct ETTIN-auxin interaction controls chromatin state in gynoecium developmentby Kuhn et al.

A fresh face in auxin perception: the plant hormone auxin directly binds transcription factor ETTIN/ARF3 to de-repress transcription.

Selected by Martin Balcerowicz. Read the preLight here

The tuatara genome: insights into vertebrate evolution from the sole survivor of an ancient reptilian orderby Gemmell et al.

A genome as old as Gondwana: a recent preprint describes the huge tuatara genome, providing insights into amniote and reptile evolution.

Selected by Miguel V. Almeida. Read the preLight here

Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responsesde Witte et al.

Patient-derived organoids meet epithelial ovarian cancer: using organoids to enable personalised therapy.

Selected by Zhang-He Goh. Read the preLight here