Species-specific developmental timing is associated with global differences in protein stability in mouse and human by Rayon et al.
Do you want (your embryonic development) to go slower? Make your proteins live longer!
The transcriptional legacy of developmental stochasticity by Ballouz et al.
Developmental stochasticity gives rise to transcriptional signatures that mark identity in armadillo quadruplets.
Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development by Saiz et al.
FGF4 signalling in the blastocyst: A simple system for an important binary cell fate decision.
Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafish by El-Maï et al.
Pushed into senescence: El-Maï and colleagues elucidate an age-related apoptosis to senescence switch in telomerase deficient zebrafish.
Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division by Ko et al.
The ins and outs of apical constriction: spatial patterns of mitosis within a contractile tissue regulate tissue invagination.
Behavioral signatures of a developing neural code by Avitan et al.
Young fish go hunting! Avitan et al. investigate the neural correlates of developing behavioral signatures.
Distinct activities of Scrib module proteins organize epithelial polarity by Khoury & Bilder
Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKC by Ventura et al.
Getting the upper hand: recent preprints describe how Lgl can be resistant to the action of aPKC with the help of ‘friends’ in the basolateral domain, whilst allowing aPKC to remain the dominant force apically.
Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early development by Pimpale et al.
Pimpale et al. show how chirality of cortical flows influences cell positioning throughout development.
Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages by Bain et al.
Tissue Residency and Sexually Dimorphic Function in Peritoneal Macrophages.
Architectural RNA is required for heterochromatin organization by Thakur et al.
Cut the anchor: CUT&RUN.RNase identifies scaffolding of heterochromatic domains by RNA.
Enhancers predominantly regulate gene expression in vivo via transcription initiation by Larke et al.
Initiation appears to be more important than pausing in transcriptional regulation.
Direct ETTIN-auxin interaction controls chromatin state in gynoecium development by Kuhn et al.
A fresh face in auxin perception: the plant hormone auxin directly binds transcription factor ETTIN/ARF3 to de-repress transcription.
The tuatara genome: insights into vertebrate evolution from the sole survivor of an ancient reptilian order by Gemmell et al.
A genome as old as Gondwana: a recent preprint describes the huge tuatara genome, providing insights into amniote and reptile evolution.
Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses de Witte et al.
Patient-derived organoids meet epithelial ovarian cancer: using organoids to enable personalised therapy.