Preformed Chromatin Topology Assists Transcriptional Robustness of Shh during Limb Development by Paliou et al.
If chromatin loops are preformed and ubiquitous, can they play a role in the regulation of a process as dynamic as developmental gene expression?
Selected by Rafael Galupa. Read the preLight here
Functional dissection of TADs reveals non-essential and instructive roles in regulating gene expression by Despang et al.
How do TADs matter in gene expression and disease? Despang et al. shed light on the (un)importance of TADs and CTCF.
Selected by Clarice Hong. Read the preLight here
Active behaviour during early development shapes glucocorticoid reactivity by Castillo-Ramírez et al.
Establishing developing zebrafish as a model system to study how early-life stress modulates stress axis function and stress responses later in life.
Selected by Kathleen Gilmour. Read the guest preLight here
The spindle assembly checkpoint functions during early development in non-chordate embryos by Chenevert et al.
To SAC or not to SAC? Shedding light on an evolutionary conundrum in early embryonic divisions.
Selected by Maiko Kitaoka. Read the preLight here
Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming by Janiszewski et al.
Gradual reactivation of the silenced X-linked genes during iPSC reprogramming: when pluripotency factors, local architecture and chromatin modifiers enter the game.
Selected by Sergio Menchero. Read the preLight here
Slide-seq: A Scalable Technology for Measuring Genome-Wide Expression at High Spatial Resolution by Rodriques et al.
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High-density spatial transcriptomics arrays for in situ tissue profiling by Vickovic et al.
No Atlas without a Map: spatially resolving single cell transcriptomes in tissues using barcoded ‘addresses’ on beads.
Selected by Carmen Adriaens. Read the preLight here
In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor by Keller et al
How to visualize glucose concentrations in vivo: the Looger lab has engineered a new family of single-wavelength glucose sensors to unravel the biology of glucose in models such as tissue culture, Drosophila and zebrafish.
Selected by Stephan Daetwyler. Read the preLight here
Over-activation of BMP signaling in neural crest cells precipitates heart outflow tract septation by Darrigrand et al.
How to divide the aorta and the pulmonary artery? 3D microscopy and single-cell analyses help to explain the role of BMP and neural crest cells as the keys to outflow tract septation in mammals.
Selected by Giulia Boezio. Read the preLight here
Mutations in the Insulator Protein Suppressor of Hairy Wing Induce Genome Instability by Hsu et al.
Arrested oogenesis, eggshell patterning defects, and DNA damage accumulation by replication stress, oh my! Drosophila's Suppressor of Hairy Wing shows that insulator proteins are not just for transcription anymore.
Selected by Maiko Kitaoka. Read the preLight here
Crowdfunded whole-genome sequencing of the celebrity cat Lil BUB identifies causal mutations for her osteopetrosis and polydactyly by Bridavsky et al.
What are the chances to suffer from more than one rare disease at the same time? The celebrity cat Lil BUB had its genome sequenced to be precisely diagnosed with the two rare mutations responsible for her unique phenotype.
Selected by Jesus Victorino Gabriel Aughey. Read the preLight here
Plant photoreceptors and their signaling components compete for binding to the ubiquitin ligase COP1 using their VP-peptide motifs by Lau et al.
Shedding light on photoreceptor action: plant photoreceptors interfere with substrate binding of the light signalling repressor COP1 by direct competition for binding sites.
Selected by Martin Balcerowicz. Read the preLight here
Accurate detection of m6A RNA modifications in native RNA sequences by Liu et al.
Hidden in plain sight: A machine learning approach uses sequencing errors to identify native RNA modifications in nanopore sequencing.
Selected by Christian Bates. Read the preLight here
Members of the Arabidopsis auxin receptor gene family are essential early in embryogenesis and have broadly overlapping functions by Prigge et al.
Auxin receptor TIR1/AFB is a happy family of genes that work together in plant embryogenesis.
Selected by Chandra Shekhar Mishra. Read the preLight here
A unicellular relative of animals generates an epithelium-like cell layer by actomyosin-dependent cellularization by Dudin et al.
(Transiently) Comfortable in its own “skin”: formation of epithelium-like multicellular structures in a unicellular organism through conserved actomyosin-dependent mechanisms.
Selected by Paul Gerald L. Sanchez and Stefano Vianello. Read the preLight here
Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity by Baek et al.
What cultivates the diversity of spinocerebellar tract neurons? Transcriptomic and genetic study suggests Hox genes to be the key.
Selected by Yen-Chung Chen. Read the preLight here
The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila by Seroka & Doe
Using time wisely: The contribution of intrinsic and extrinsic temporal cues towards cellular identity in the Drosophila nervous system.
Selected by Abagael Lasseigne. Read the preLight here
Distinct RhoGEFs activate apical and junctional actomyosin contractility 2 under control of G proteins during epithelial morphogenesis by De Las Bayonas et al.
Two independent ways tune Rho1 activity: ‘Wireless’ and ‘non-Wireless’.
Selected by Ivana Viktorinova. Read the preLight here
The visual system of the genetically tractable crustacean Parhyale hawaiensis: diversification of eyes and visual circuits associated with low-resolution vision by Ramos et al.
Exploring the diversity of visual systems: Parhyale hawaiensis envision us on arthropod vision evolution.
Selected by Alexa Sadier. Read the preLight here
