Glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesisby Chi et al.

It's a sweet story: Glucose metabolism regulates YAP localization and AP-2gamma translation to control the first cell fate decision in development.

Selected by Grace Lim. Read the preLight here

A sheath of motile cells supports collective migration in of the Zebrafish posterior lateral line primordium under the skinby Dalle Nogare et al.

More than just a barrier – the skin interacts with the posterior lateral line primordium in zebrafish to ensure collective cell migration.

Selected by Karen Groß. Read the preLight here

Building customizable auto-luminescent luciferase-based reporters in plantsby Khakhar et al.


Plants with self-sustained luminescenceby Mitiouchkina et al.

Night-light plants! A fungal bioluminescence pathway adapted for use in plants results in an auto-luminescent reporter system.

Selected by Martin Balcerowicz and Jonny Coates. Read the preLight here

ROS production by localized SCHENGEN receptor module drives lignification at subcellular precisionby Fujita et al.

It's all about localization, localization, localization! Unraveling the SCHENGEN signaling pathway guiding localized lignification of the Casparian strip.

Selected by Marc Somssich. Read the preLight here

Subcellular mRNA localization regulates ribosome biogenesis in migrating cellsby Dermit et al.

Take me to the tip- localized translation of ribosomal proteins at cell protrusions governs cancer metastasis.

Selected by Nidhi Kanwal. Read the preLight here

Identification of neural oscillations and epileptiform changes in human brain organoidsby Samarasinghe et al.

Excitatory/inhibitory fusion organoids OSCILLATE! In combination with iPSC technology this allows patient specific drug tailoring, as exemplified by Rett Syndrome in this preprint.

Selected by Theresa Pohlkamp. Read the preLight here

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analysesby Okkelman et al.

Shedding light on unique metabolic properties of the Lgr5+ stem cell niche by O2 phosphorescence & NAD(P)H fluorescence imaging of intestinal organoids.

Selected by Jessica Xie. Read the preLight here

Multiple overlapping hypothalamus-brainstem circuits drive rapid threat avoidanceby Lovett-Barron et al.

Stressed? The hypothalamus in action again, but it's complicated! Lovett-Barron et al. investigate the brain areas controlling stress-induced avoidance behaviour.

Selected by Amrutha Swaminathan and Rudra Nayan Das. Read the preLight here

Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesityby Prola et al.

A mitochondrial defect with unexpected consequences. Reduced cardiolipin content in mitochondrial membranes impairs phosphorylating respiration but protects Hacd1-deficient mice against diet-induced obesity.

Selected by Pablo Ranea Robles. Read the preLight here

Senescence of alveolar stem cells drives progressive pulmonary fibrosisby Yao et al.

In pulmonary fibrosis, alveolar type II stem cells become senescent. In a mouse model, genetic induction of senescence in this population was sufficient to cause TGFβ-dependent progressive fibrosis, in contrast to existing rapidly resolving models.

Selected by Rob Hynds. Read the preLight here

Rapid Ultrastructural Changes of PSD and Extrasynaptic Axon-spine Interface Membrane during LTP Induced in Single Dendritic Spineby Sun et al.

Shining a light on the synapse: using targeted glutamate uncaging and electron microscopy to study changing dendritic spines and synaptic strengthening.

Selected by Alyson Smith. Read the preLight here

EXO70A2 is critical for the exocyst complex function in Arabidopsis pollenby Marković et al.

Exocyst complex component EXO70A2 plays a vital role in male gametophyte development and is required for successful fertilization.

Selected by Chandra Shekhar Misra. Read the preLight here

bioRxiv: the preprint server for biologyby Sever et al.

More than 64,000 research articles have been shared through the life sciences preprint server bioRxiv as changes in the scientific publication landscape gather pace.

Selected by Jonny Coates and Rob Hynds. Read the preLight here