Glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis by Chi et al.
It's a sweet story: Glucose metabolism regulates YAP localization and AP-2gamma translation to control the first cell fate decision in development.
A sheath of motile cells supports collective migration in of the Zebrafish posterior lateral line primordium under the skin by Dalle Nogare et al.
More than just a barrier – the skin interacts with the posterior lateral line primordium in zebrafish to ensure collective cell migration.
Building customizable auto-luminescent luciferase-based reporters in plants by Khakhar et al.
Plants with self-sustained luminescence by Mitiouchkina et al.
Night-light plants! A fungal bioluminescence pathway adapted for use in plants results in an auto-luminescent reporter system.
ROS production by localized SCHENGEN receptor module drives lignification at subcellular precision by Fujita et al.
It's all about localization, localization, localization! Unraveling the SCHENGEN signaling pathway guiding localized lignification of the Casparian strip.
Subcellular mRNA localization regulates ribosome biogenesis in migrating cells by Dermit et al.
Take me to the tip- localized translation of ribosomal proteins at cell protrusions governs cancer metastasis.
Identification of neural oscillations and epileptiform changes in human brain organoids by Samarasinghe et al.
Excitatory/inhibitory fusion organoids OSCILLATE! In combination with iPSC technology this allows patient specific drug tailoring, as exemplified by Rett Syndrome in this preprint.
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses by Okkelman et al.
Shedding light on unique metabolic properties of the Lgr5+ stem cell niche by O2 phosphorescence & NAD(P)H fluorescence imaging of intestinal organoids.
Multiple overlapping hypothalamus-brainstem circuits drive rapid threat avoidance by Lovett-Barron et al.
Stressed? The hypothalamus in action again, but it's complicated! Lovett-Barron et al. investigate the brain areas controlling stress-induced avoidance behaviour.
Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity by Prola et al.
A mitochondrial defect with unexpected consequences. Reduced cardiolipin content in mitochondrial membranes impairs phosphorylating respiration but protects Hacd1-deficient mice against diet-induced obesity.
Senescence of alveolar stem cells drives progressive pulmonary fibrosis by Yao et al.
In pulmonary fibrosis, alveolar type II stem cells become senescent. In a mouse model, genetic induction of senescence in this population was sufficient to cause TGFβ-dependent progressive fibrosis, in contrast to existing rapidly resolving models.
Rapid Ultrastructural Changes of PSD and Extrasynaptic Axon-spine Interface Membrane during LTP Induced in Single Dendritic Spine by Sun et al.
Shining a light on the synapse: using targeted glutamate uncaging and electron microscopy to study changing dendritic spines and synaptic strengthening.
EXO70A2 is critical for the exocyst complex function in Arabidopsis pollen by Marković et al.
Exocyst complex component EXO70A2 plays a vital role in male gametophyte development and is required for successful fertilization.
bioRxiv: the preprint server for biology by Sever et al.
More than 64,000 research articles have been shared through the life sciences preprint server bioRxiv as changes in the scientific publication landscape gather pace.