Embryonic geometry underlies phenotypic variation in decanalized conditions by Huang & Saunders
Gene regulatory networks provide robustness against variation in embryonic geometry.
Selected by Sundar Naganathan. Read the preLight here
Developmentally regulated Shh expression is robust to TAD perturbations by Williamson et al.
Are TAD borders that important to prevent enhancer rewiring? Tissue-specific enhancers maintain robust control of Shh gene expression after challenging the architectural chromatin context.
Selected by Jesus Victorino. Read the preLight here
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila by Port et al.
Bringing CRISPR to the masses: New tools for in vivo genome editing in flies.
Selected by Gabriel Aughey. Read the preLight here
Actin chromobody imaging reveals sub-organellar actin dynamics by Schiavon et al.
Nanobody technology allows live imaging of sub-organellar actin dynamics at previously unachieved temporal and spatial resolution, and exploring its relevance for organelle fission.
Selected by Mariana De Niz. Read the preLight here
AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation by Ghosh et al.
When do stop signs become optional? Ghosh et al. report an important role for an AGO1 isoform generated by translational readthrough.
Selected by Lorenzo Lafranchi. Read the preLight here
Snail induces epithelial cell extrusion through transcriptional control of RhoA contractile signaling and cell matrix adhesion by Wee et al.
Contract, de-adhere and extrude.
Selected by Ankita Jha. Read the preLight here
Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signalling by Segura-Bayona et al.
Tousled-like kinase activity - an intricate connection between heterochromatin assembly, genome instability and innate immune responses.
Selected by Yasmin Lau. Read the preLight here
Intravital optoacoustic ultrasound bio-microscopy reveals radiation-inhibited skull angiogenesis by Estrada et al.
Shedding light on skull and cerebral vascular changes: optoacoustic ultrasound bio-imaging shows irradiation effects on angiogenesis inhibition.
Selected by Mariana De Niz. Read the preLight here
Oncogenic signaling alters cell shape and mechanics to facilitate cell division under confinement by Matthews et al.
Cancer cells know when to be stiff.
Selected by Ankita Jha. Read the preLight here
3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK by Taubenberger et al.
Tuning and probing the stiffness of 3D microenvironments for interrogating its mechanical impact on tumour spheroid growth.
Selected by Jacky Goetz. Read the preLight here
Co-reviewing and ghostwriting by early career researchers in the peer review of manuscripts by McDowell et al.
Ghost in the machine: widespread uncredited participation by early career researchers in peer review raises ethical flags, but provides opportunities for change.
Selected by Gautam Dey and Tessa Sinnige. Read the preLight here
