Simultaneous production of diverse neuronal subtypes during early corticogenesisby Magrinelli et al.

How does the amazing diversity of cortical neurons emerge during development? A new preprint suggests that during early stages distinct types are simultaneously produced, while later on neuronal production is homogenous and sequential.

Selected by Boyan Bonev. Read the preLight here

Neural crest cells regulate optic cup morphogenesis by promoting extracellular matrix assemblyby Bryan et al.

Ocular Origami: Bryan and colleagues discover that in the developing zebrafish eye, cell and tissue movements in the optic cup are dependent on the extracellular matrix protein nidogen provided by surrounding neural crest cells.

Selected by Ashrifia Adomako-Ankomah. Read the preLight here

The creation of sexual dimorphism in Drosophila gonad stem cell nichesby Camara et al.

Battle of the Sexes: Doublesex tips the balance between male and female programs for gonadal stem cell niche development.

Selected by Natalie Dye. Read the preLight here

Quantitative, real-time, single cell analysis in tissue reveals expression dynamics of neurogenesisby Manning et al.

Cell state transitions in real time: stochastic and oscillatory dynamics of neural progenitors revealed through live cell imaging of Hes5.

Selected by Teresa Rayon. Read the preLight here

mRNA localisation in endothelial cells regulates blood vessel sproutingby Costa et al.

rab13 transcripts are targeted to and locally translated at the leading edge of migrating endothelial cells which fine-tunes their protrusive activity during developmental angiogenesis.

Selected by Andreas van Impel. Read the preLight here

A cell cycle-coordinated nuclear compartment for Polymerase II transcription encompasses the earliest gene expression before global genome activationby Hadzhiev et al.

A pocket in the nucleus: Hadzhiev and colleages discover that rapidly dividing cells in zebrafish embryos hold a special nuclear compartment for the earliest wave of gene expression.

Selected by Idoia Quintana-Urzainqui. Read the preLight here

Molecular recording of mammalian embryogenesisby Chan et al.

Molecular recording of mammalian development, one cell at a time.

Selected by Hannah Brunsdon. Read the preLight here

A transmissible RNA pathway in honey beesby Maori et al.

The proof is in the (jelly) pudding: bees horizontally transmit ingested biologically active RNA to peers and future generations by secreting it into worker and royal jellies in a remarkable process of social immunity and signalling.

Selected by Nicola Stevenson. Read the preLight here

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages is necessary for functional spinal cord regeneration in zebrafishby Tsarouchas et al.

To regenerate, or not to regenerate? Researchers shed light on key immune mechanisms and spatiotemporal dynamics that orchestrate spinal cord regeneration in zebrafish.

Selected by Shikha Nayar. Read the preLight here

The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophilaby Zandvakili et al.

From sequence to function: a recent preprint highlights the importance of binding site orientation and spacing for determining transcription factor activity.

Selected by Clarice Hong. Read the preLight here

LADL: Light-activated dynamic looping for endogenous gene expression controlby Rege et al.

Travelling over long distances: a new study uses blue light to make two (genomic) locations come together – providing an exciting new tool to study gene regulation.

Selected by Ivan Candido-Ferreira. Read the preLight here

SOL1 and SOL2 Regulate Fate Transition and Cell Divisions in the Arabidopsis Stomatal Lineageby Simmons et al.

Changing a cell's destiny: SOL1 and SOL2 are novel regulators of cell fate in the Arabidopsis stomatal lineage.

Selected by Martin Balcerowicz. Read the preLight here

Analysis of the role of Nidogen/entactin in basement membrane assembly and morphogenesis in Drosophilaby Martin-Bermudo et al.

Necessary, or unnecessary, that is the question: Nidogen is not essential for overall Drosophila morphogenesis and viability, but required for proper basement membrane assembly in certain tissues.

Selected by Nargess Khalilgharibi. Read the preLight here

Optogenetic manipulation of medullary neurons in the locust optic lobeby Wang et al.

Optogenetics in the locust brain: lights open new doors into the study of neuronal circuits in insects.

Selected by Ana Patricia Ramos. Read the preLight here

A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cellsby Buitrago-Delgado et al.

The neural crest, the last frontier of stemness and pluripotency of the developing vertebrate embryo, is maintained purposefully and distinctly by SoxE transcription factors.

Selected by Amanda Haage. Read the preLight here

Visit The Node to see the latest monthly round-up of preprints in the developmental biology field.