Simultaneous production of diverse neuronal subtypes during early corticogenesis by Magrinelli et al.
How does the amazing diversity of cortical neurons emerge during development? A new preprint suggests that during early stages distinct types are simultaneously produced, while later on neuronal production is homogenous and sequential.
Neural crest cells regulate optic cup morphogenesis by promoting extracellular matrix assembly by Bryan et al.
Ocular Origami: Bryan and colleagues discover that in the developing zebrafish eye, cell and tissue movements in the optic cup are dependent on the extracellular matrix protein nidogen provided by surrounding neural crest cells.
The creation of sexual dimorphism in Drosophila gonad stem cell niches by Camara et al.
Battle of the Sexes: Doublesex tips the balance between male and female programs for gonadal stem cell niche development.
Quantitative, real-time, single cell analysis in tissue reveals expression dynamics of neurogenesis by Manning et al.
Cell state transitions in real time: stochastic and oscillatory dynamics of neural progenitors revealed through live cell imaging of Hes5.
mRNA localisation in endothelial cells regulates blood vessel sprouting by Costa et al.
rab13 transcripts are targeted to and locally translated at the leading edge of migrating endothelial cells which fine-tunes their protrusive activity during developmental angiogenesis.
A cell cycle-coordinated nuclear compartment for Polymerase II transcription encompasses the earliest gene expression before global genome activation by Hadzhiev et al.
A pocket in the nucleus: Hadzhiev and colleages discover that rapidly dividing cells in zebrafish embryos hold a special nuclear compartment for the earliest wave of gene expression.
Molecular recording of mammalian embryogenesis by Chan et al.
Molecular recording of mammalian development, one cell at a time.
A transmissible RNA pathway in honey bees by Maori et al.
The proof is in the (jelly) pudding: bees horizontally transmit ingested biologically active RNA to peers and future generations by secreting it into worker and royal jellies in a remarkable process of social immunity and signalling.
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages is necessary for functional spinal cord regeneration in zebrafish by Tsarouchas et al.
To regenerate, or not to regenerate? Researchers shed light on key immune mechanisms and spatiotemporal dynamics that orchestrate spinal cord regeneration in zebrafish.
The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila by Zandvakili et al.
From sequence to function: a recent preprint highlights the importance of binding site orientation and spacing for determining transcription factor activity.
LADL: Light-activated dynamic looping for endogenous gene expression control by Rege et al.
Travelling over long distances: a new study uses blue light to make two (genomic) locations come together – providing an exciting new tool to study gene regulation.
SOL1 and SOL2 Regulate Fate Transition and Cell Divisions in the Arabidopsis Stomatal Lineage by Simmons et al.
Changing a cell's destiny: SOL1 and SOL2 are novel regulators of cell fate in the Arabidopsis stomatal lineage.
Analysis of the role of Nidogen/entactin in basement membrane assembly and morphogenesis in Drosophila by Martin-Bermudo et al.
Necessary, or unnecessary, that is the question: Nidogen is not essential for overall Drosophila morphogenesis and viability, but required for proper basement membrane assembly in certain tissues.
Optogenetic manipulation of medullary neurons in the locust optic lobe by Wang et al.
Optogenetics in the locust brain: lights open new doors into the study of neuronal circuits in insects.
A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells by Buitrago-Delgado et al.
The neural crest, the last frontier of stemness and pluripotency of the developing vertebrate embryo, is maintained purposefully and distinctly by SoxE transcription factors.
Visit The Node to see the latest monthly round-up of preprints in the developmental biology field.